{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:30:29Z","timestamp":1790620229477,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPQ","award":["420142\/2023-1"],"award-info":[{"award-number":["420142\/2023-1"]}]},{"name":"Instituto Tecnologico Vale (ITV)","award":["420142\/2023-1"],"award-info":[{"award-number":["420142\/2023-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Background: The Amazon biome exhibits complex arboviral transmission dynamics influenced by accelerating deforestation, climate change, and socioeconomic inequities. Objectives\/Methods: This study integrates official epidemiological records with socioeconomic, environmental, and climate variables by applying advanced geostatistical methods (Moran\u2019s I, SaTScan, kernel density estimation) combined with principal component analysis and negative binomial regression to assess the spatiotemporal dynamics of dengue incidence and its association with socio-environmental determinants across municipalities in Par\u00e1 state (eastern Brazilian Amazon) from 2010 to 2024. Results: Dengue incidence showed an overall decline but with marked epidemic peaks in 2010\u20132012, 2016, and 2024. The spatial analysis revealed significant clustering (Moran\u2019s I = 0.221, p &lt; 0.01), with persistent high-risk hotspots across most of Par\u00e1. Of 144 municipalities, 104 exhibited significant dengue risk, while 58 maintained sustained transmission. Negative binomial regression model identified key determinants: illiteracy, low urbanization, reduced GDP, and climate variables. Conclusions: Dengue transmission in the Amazon is driven by synergistic socio-environmental disruptions, necessitating intersectoral policies that bridge public health surveillance, sustainable land-use governance, and poverty alleviation. Priority actions include targeted vector control in high-risk clusters, coupled with integrated deforestation and climate monitoring to predict outbreak risks. The findings emphasize the urgency of implementing multisectoral interventions tailored to the territorial and socio-environmental complexities of vulnerable Amazonian regions for effective dengue control.<\/jats:p>","DOI":"10.3390\/idr17040099","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T17:22:07Z","timestamp":1754932927000},"page":"99","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spatiotemporal Dynamics of Dengue in the State of Par\u00e1 and the Socio-Environmental Determinants in Eastern Brazilian Amazon"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-7486","authenticated-orcid":false,"given":"Brenda Caroline Sampaio","family":"da Silva","sequence":"first","affiliation":[{"name":"Programa de Pos-Gradua\u00e7\u00e3o em Ci\u00eancias Ambientais (PPGCA), Instituto de Geoci\u00eancias, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-4765","authenticated-orcid":false,"given":"Ricardo Jos\u00e9 de Paula Souza e","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Geoprocessamento, Instituto Evandro Chagas, Ananindeua 67030-000, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-9885","authenticated-orcid":false,"given":"Bruno Spacek","family":"Godoy","sequence":"additional","affiliation":[{"name":"Programa de Pos-Gradua\u00e7\u00e3o em Ci\u00eancias Ambientais (PPGCA), Instituto de Geoci\u00eancias, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"},{"name":"Instituto Amaz\u00f4nico de Agriculturas Familiares, Universidade Federal do Par\u00e1, Bel\u00e9m 66077-530, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa Tavares","family":"Parente","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal do Par\u00e1, Bel\u00e9m 67075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bergson Cavalcanti","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Faculdade de Meteorologia, Programa de Pos-Gradua\u00e7\u00e3o em Gest\u00e3o de Risco e Desastre na Amaz\u00f4nia, Instituto de Geoci\u00eancias, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Aparecida da Silva","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Programa de Pos-Gradua\u00e7\u00e3o em Ci\u00eancias Ambientais (PPGCA), Instituto de Geoci\u00eancias, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8868-7235","authenticated-orcid":false,"given":"Douglas Batista da Silva","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico Vale, Bel\u00e9m 67055-090, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2670-5805","authenticated-orcid":false,"given":"Emilene Monteiro Furtado","family":"Serra","sequence":"additional","affiliation":[{"name":"Programa de Pos-Gradua\u00e7\u00e3o em Ci\u00eancias Ambientais (PPGCA), Instituto de Geoci\u00eancias, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o de Athaydes","family":"Silva Junior","sequence":"additional","affiliation":[{"name":"Faculdade de Meteorologia, Programa de Pos-Gradua\u00e7\u00e3o em Gest\u00e3o de Risco e Desastre na Amaz\u00f4nia, Instituto de Geoci\u00eancias, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3270-6679","authenticated-orcid":false,"given":"Luciano Jorge Serejo","family":"dos Anjos","sequence":"additional","affiliation":[{"name":"Programa de Pos-Gradua\u00e7\u00e3o em Ci\u00eancias Ambientais (PPGCA), Instituto de Geoci\u00eancias, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-0984","authenticated-orcid":false,"given":"Everaldo Barreiros","family":"de Souza","sequence":"additional","affiliation":[{"name":"Programa de Pos-Gradua\u00e7\u00e3o em Ci\u00eancias Ambientais (PPGCA), Instituto de Geoci\u00eancias, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"},{"name":"Faculdade de Meteorologia, Programa de Pos-Gradua\u00e7\u00e3o em Gest\u00e3o de Risco e Desastre na Amaz\u00f4nia, Instituto de Geoci\u00eancias, Universidade Federal do Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shabbir, W., Pilz, J., and Naeem, A. 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