{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:52:43Z","timestamp":1778215963269,"version":"3.51.4"},"reference-count":34,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Introduction: Hyponatremia is a common finding in hospitalized patients, especially the elderly. Symptoms of hyponatremia can vary depending on the concentration of sodium in serum as well as the dynamics of its escalation. Hyponatremia can have many etiologies, including medication, vomiting, or diarrhea, and central nervous system disorders, including tumors, trauma, and infections. Case report: In this case, we present a 74-year-old patient who was admitted to the Department of Internal Medicine with symptomatic, acute, and severe hyponatremia in the course of the syndrome of inappropriate antidiuretic hormone secretion due to varicella zoster virus meningoencephalitis. Clinical improvement and normalization of natremia occurred after the initiation of causal treatment. Conclusion: Given the complexity of the potential causes of hyponatremia and the variety of treatments available, it is essential to thoroughly consider the possible reasons for electrolyte abnormalities, including uncommon ones such as central nervous system infections.<\/jats:p>","DOI":"10.3390\/idr17050106","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T08:28:15Z","timestamp":1756715295000},"page":"106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyponatremia Due to VZV-Induced SIADH in an Older Patient: Case Report and Literature Review"],"prefix":"10.3390","volume":"17","author":[{"given":"Zuzanna","family":"\u017bak-Skry\u015bkiewicz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Endocrinology and Diabetes, Medical University of Warsaw, 02-091 Warsaw, Poland"},{"name":"Department of Internal Medicine, Endocrinology and Diabetes, Mazovian Br\u00f3dnowski Hospital, Kondratowicza 8, 03-242 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Krupi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology and Diabetes, Mazovian Br\u00f3dnowski Hospital, Kondratowicza 8, 03-242 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-4576","authenticated-orcid":false,"given":"Carlo","family":"Bie\u0144kowski","sequence":"additional","affiliation":[{"name":"Department of Adults\u2019 Infectious Diseases, Medical University of Warsaw, Wolska 37, 01-201 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Przemys\u0142aw","family":"Witek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology and Diabetes, Medical University of Warsaw, 02-091 Warsaw, Poland"},{"name":"Department of Internal Medicine, Endocrinology and Diabetes, Mazovian Br\u00f3dnowski Hospital, Kondratowicza 8, 03-242 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lu, H., Vollenweider, P., Kissling, S., and Marques-Vidal, P. (2020). Prevalence and Description of Hyponatremia in a Swiss Tertiary Care Hospital: An Observational Retrospective Study. Front. Med., 7.","DOI":"10.3389\/fmed.2020.00512"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1530\/EJE-15-0111","article-title":"Hyponatremia and mortality risk: A Danish cohort study of 279,508 acutely hospitalized patients","volume":"173","author":"Christiansen","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s41999-020-00320-3","article-title":"Prevalence of hyponatremia among older inpatients in a general hospital","volume":"11","author":"Zhang","year":"2020","journal-title":"Eur. Geriatr. Med."},{"key":"ref_4","unstructured":"Peri, A., Thompson, C.J., and Verbalis, J.G. (2019). Etiology and Epidemiology of Hyponatremia. Frontiers of Hormone Research [Internet], Karger Publishers. Available online: https:\/\/www.karger.com\/Article\/FullText\/493234."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Cui, H., He, G., Yang, S., Lv, Y., Jiang, Z., Gang, X., and Wang, G. (2019). Inappropriate Antidiuretic Hormone Secretion and Cerebral Salt-Wasting Syndromes in Neurological Patients. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.01170"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lim, A.K.H., Paramaswaran, S., Jellie, L.J., and Junckerstorff, R.K. (2019). A Cross-Sectional Study of Hyponatremia Associated with Acute Central Nervous System Infections. J. Clin. Med., 8.","DOI":"10.3390\/jcm8111801"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s10096-024-04855-2","article-title":"Clinical characteristics and factors affecting disease severity in hospitalized tick-borne encephalitis patients in Norway from 2018 to 2022","volume":"43","author":"Skudal","year":"2024","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/qjmed\/hcl131","article-title":"Hyponatraemia in adults with community-acquired bacterial meningitis","volume":"100","author":"Brouwer","year":"2006","journal-title":"QJM"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S1473-3099(18)30245-7","article-title":"Incidence, aetiology, and sequelae of viral meningitis in UK adults: A multicentre prospective observational cohort study","volume":"18","author":"McGill","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12985-023-02079-y","article-title":"Epidemiological characterization of viral etiological agents of the central nervous system infections among hospitalized patients in Egypt between 2016 and 2019","volume":"20","author":"Roshdy","year":"2023","journal-title":"Virol. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/jmv.23470","article-title":"Viral infections of the central nervous system in Spain: A prospective study","volume":"85","author":"Trallero","year":"2013","journal-title":"J. Med. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Patil, A., Goldust, M., and Wollina, U. (2022). Herpes zoster: A Review of Clinical Manifestations and Management. Viruses, 14.","DOI":"10.3390\/v14020192"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kr\u00f3licka, A.L., Kruczkowska, A., Krajewska, M., and Kusztal, M.A. (2020). Hyponatremia in Infectious Diseases\u2014A Literature Review. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17155320"},{"key":"ref_14","unstructured":"Szczeklik, A. (2022). Interna Szczeklika 2022, Polski Instytut Evidence Based Medicine. [14th ed.]."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2147\/TCRM.S206066","article-title":"Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management","volume":"16","author":"Mentrasti","year":"2020","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_16","unstructured":"Tenny, S., and Thorell, W. (2025, June 02). Cerebral Salt Wasting Syndrome, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534855\/."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fped.2014.00146","article-title":"Syndrome of Inappropriate Antidiuretic Hormone Secretion and Cerebral\/Renal Salt Wasting Syndrome: Similarities and Differences","volume":"2","author":"Oh","year":"2015","journal-title":"Front Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/ejhf.2848","article-title":"Natriuretic peptides: Role in the diagnosis and management of heart failure: A scientific statement from the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society","volume":"25","author":"Tsutsui","year":"2023","journal-title":"Eur. J. Heart Fail."},{"key":"ref_19","first-page":"149","article-title":"Meningitis and Ramsay-Hunt syndrome in a 17-year old girl","volume":"40","author":"Bienkowski","year":"2019","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2013.07.006","article-title":"Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations","volume":"126","author":"Verbalis","year":"2013","journal-title":"Am. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/00365513.2015.1129669","article-title":"Comparison of hyponatremia and SIADH frequency in patients with tick borne encephalitis and meningitis of other origin","volume":"76","author":"Czupryna","year":"2016","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"ref_22","first-page":"360","article-title":"Frequency of Hyponatremia in Adults with Acute Bacterial Meningitis","volume":"33","author":"Rashid","year":"2024","journal-title":"Mymensingh Med. J."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Na, S., Kim, T., Song, I.U., Chung, S.W., Kim, S.H., Oh, Y.S., Oh, J., and Kim, W. (2021). The association between serum sodium level and tuberculous meningitis compared with viral and bacterial meningitis. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-90358-5"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1620\/tjem.247.189","article-title":"Hyponatremia Is Predictive of HSV-1 Encephalitis among Patients with Viral Encephalitis","volume":"247","author":"Basaran","year":"2019","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_25","first-page":"491","article-title":"Meningitis\/meningoencephalitis caused by varicella zoster virus reactivation: A retrospective single-center case series study","volume":"14","author":"Yan","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/1346-8138.16666","article-title":"Recent topics in the management of herpes zoster","volume":"50","author":"Asada","year":"2023","journal-title":"J. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/QCO.0000000000000647","article-title":"Central nervous system infections produced by varicella zoster virus","volume":"33","author":"Nagel","year":"2020","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1001\/archinte.1983.00350060202037","article-title":"Disseminated varicella-zoster virus infection with the syndrome of inappropriate antidiuretic hormone","volume":"143","author":"Ingraham","year":"1983","journal-title":"Arch. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jocn.2017.03.007","article-title":"An unusual presentation of varicella zoster virus with acute cerebellitis and SIADH without a rash","volume":"41","author":"Lubomski","year":"2017","journal-title":"J. Clin. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.2169\/internalmedicine.0785-18","article-title":"SIADH with Severe Hyponatremia in an Elderly Man with Herpes Zoster Infection: A Causal or Casual Association?","volume":"57","author":"Foppiani","year":"2018","journal-title":"Intern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"omx065","DOI":"10.1093\/omcr\/omx065","article-title":"Localized herpes zoster infection: A rare cause of syndrome of inappropriate secretion of antidiuretic hormone","volume":"2017","author":"Bassi","year":"2017","journal-title":"Oxf. Med. Case Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s11606-010-1517-4","article-title":"Syndrome of Inappropriate Secretion of Antidiuretic Hormone Associated with Localized Herpes Zoster Ophthalmicus","volume":"26","author":"Wang","year":"2011","journal-title":"J. Gen. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1046\/j.1365-2133.2003.05656.x","article-title":"Disseminated zoster, hyponatraemia, severe abdominal pain and leukaemia relapse: Recognition of a new clinical quartet after bone marrow transplantation","volume":"149","author":"Au","year":"2003","journal-title":"Br. J. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/imj.12977","article-title":"Disseminated visceral varicella zoster virus presenting with the constellation of colonic pseudo-obstruction, acalculous cholecystitis and syndrome of inappropriate ADH secretion","volume":"46","author":"Braude","year":"2016","journal-title":"Intern. Med. J."}],"container-title":["Infectious Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2036-7449\/17\/5\/106\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:36:01Z","timestamp":1760034961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7449\/17\/5\/106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["idr17050106"],"URL":"https:\/\/doi.org\/10.3390\/idr17050106","relation":{},"ISSN":["2036-7449"],"issn-type":[{"value":"2036-7449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,30]]}}}