{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:51:45Z","timestamp":1780048305777,"version":"3.53.1"},"reference-count":51,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation SEIMC-GESIDA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Background\/Objectives: This study aimed to determine the prevalence of persistent symptoms and the radiological and laboratory evolution at 6 months and 5 years after discharge in patients hospitalized for SARS-CoV-2 pneumonia during the first wave of the pandemic in Spain and to estimate the healthcare impact of their follow-up. Methods: A retrospective longitudinal observational study was conducted at the \u201cHospital Central de la Defensa\u201d. A total of 200 patients aged &gt;18 years with a diagnosis of SARS-CoV-2 pneumonia were screened. Clinical, radiological, and laboratory data were collected from electronic medical records. Patients with symptoms or radiological abnormalities at discharge underwent in-person evaluations, while the remainder were assessed by telephone. Results: A total of 182 patients met the inclusion and exclusion criteria. Of these, 112 were assessed in the outpatient setting; 60.7% required in-person evaluations, with normal pulmonary auscultation in 93.6%, complete radiological resolution in 85%, and normalized laboratory parameters in almost all cases. At 6 months, 26.5% presented at least one residual symptom, whereas only three patients (4.5%) reported symptoms at 5 years. No risk factors associated with symptom persistence were identified. The estimated cumulative healthcare cost was EUR 21,627.50. Conclusions: Among patients hospitalized for SARS-CoV-2 pneumonia during the first wave of the pandemic, 26.7% and 4.46% presented at least one persistent symptom at 6 months and 5 years after discharge, respectively.<\/jats:p>","DOI":"10.3390\/idr18010008","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:09:06Z","timestamp":1767946146000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Persistence of Symptoms and Long-Term Recovery in Hospitalized COVID-19 Patients: Results from a Five-Year Follow-Up Cohort"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1318-414X","authenticated-orcid":false,"given":"Ana Roel","family":"Conde","sequence":"first","affiliation":[{"name":"University of Alcal\u00e1, Plaza de San Diego, 28801 Alcal\u00e1 de Henares, Madrid, Spain"},{"name":"Department of Internal Medicine, Hospital Central de la Defensa \u201cG\u00f3mez Ulla\u201d, 28047 Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5330-5540","authenticated-orcid":false,"given":"Francisco Javier Membrillo","family":"de Novales","sequence":"additional","affiliation":[{"name":"CBRN and Infectious Diseases Department, Hospital Central de la Defensa \u201cG\u00f3mez Ulla\u201d, 28047 Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Navarro","family":"T\u00e9llez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Central de la Defensa \u201cG\u00f3mez Ulla\u201d, 28047 Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Guti\u00e9rrez","family":"Ortega","sequence":"additional","affiliation":[{"name":"University of Alcal\u00e1, Plaza de San Diego, 28801 Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-9123","authenticated-orcid":false,"given":"Miriam Est\u00e9banez","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"University of Alcal\u00e1, Plaza de San Diego, 28801 Alcal\u00e1 de Henares, Madrid, Spain"},{"name":"CBRN and Infectious Diseases Department, Hospital Central de la Defensa \u201cG\u00f3mez Ulla\u201d, 28047 Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.idc.2022.02.004","article-title":"Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection","volume":"36","author":"Hope","year":"2022","journal-title":"Infect. 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