{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T01:27:08Z","timestamp":1783560428999,"version":"3.55.0"},"reference-count":43,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Laboratory Medicine and Pathology, Faculty of Medicine and Health Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Background: Rabies remains a neglected zoonotic disease in South Africa, particularly in rural areas where surveillance weaknesses, behavioral gaps, and limited One Health coordination persist. Objectives: This study assessed rabies surveillance, behavioral risk factors, and system responsiveness in two rural Eastern Cape communities, with a focus on post-pandemic resilience within a One Health framework. Methods: A cross-sectional, community-based pilot study was conducted among 109 residents using structured questionnaires to collect data on demographics, rabies awareness, vaccination practices, and service disruptions. Descriptive, bivariate, and multivariate analyses identified predictors of dog-bite exposure and pet vaccination. Machine learning models (Decision Tree and Random Forest) were applied to explore risk hierarchies. A composite Surveillance Gap Index (SGI) was developed to integrate behavioral and systemic indicators. Results: While 88% of participants were aware of rabies, only 35% attended awareness campaigns. Dog-bite exposure affected 51% of households, with significantly higher risk among males (aOR = 4.33; p = 0.003). Education was positively associated with pet vaccination (aOR = 1.78). Despite 45% reporting COVID-19 disruptions, communities maintained high post-pandemic vaccination coverage (85.7%). Predictive models (AUC = 0.82\u20130.86) identified education, gender, awareness, and distance as key risk drivers. Conclusions: Integrating behavioral insights and predictive analytics into One Health strategies can strengthen rabies surveillance and support progress toward eliminating human rabies by 2030.<\/jats:p>","DOI":"10.3390\/idr18020020","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:58:18Z","timestamp":1771952298000},"page":"20","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post-COVID-19 Rabies Surveillance and Risk Factors in Rural Eastern Cape, South Africa: A One Health Perspective"],"prefix":"10.3390","volume":"18","author":[{"given":"Sithabile","family":"Moso","sequence":"first","affiliation":[{"name":"One Health and Neglected Tropical Diseases Research Group, School of Laboratory Medicine and Pathology, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5099, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-2176","authenticated-orcid":false,"given":"Laston","family":"Gonah","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5099, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-787X","authenticated-orcid":false,"given":"Mojisola Clara","family":"Hosu","sequence":"additional","affiliation":[{"name":"One Health and Neglected Tropical Diseases Research Group, School of Laboratory Medicine and Pathology, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5099, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ntandazo","family":"Dlatu","sequence":"additional","affiliation":[{"name":"Walter Sisulu Institute for Clinical Governance, Healthcare Administration, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5099, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-3864","authenticated-orcid":false,"given":"Teke","family":"Apalata","sequence":"additional","affiliation":[{"name":"One Health and Neglected Tropical Diseases Research Group, School of Laboratory Medicine and Pathology, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5099, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7308-4239","authenticated-orcid":false,"given":"Lindiwe Modest","family":"Faye","sequence":"additional","affiliation":[{"name":"One Health and Neglected Tropical Diseases Research Group, School of Laboratory Medicine and Pathology, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5099, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, October 15). 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