{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T19:00:15Z","timestamp":1784055615589,"version":"3.55.0"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Birth weight can be a predictor of maternal health issues related to nutrition and environmental contaminants. Total hair mercury (HHg) concentration was studied as an indicator of both fish consumption and methylmercury exposure in mothers (and newborns) living in selected low income areas of the Madeira River basin, Amazonia, Brazil. This cohort study (n = 1,433) consisted of traditional riverines (n = 396), riverines who had moved to urban (n = 676) and rural (n = 67) settings, and tin miner settlers  (n = 294). Median maternal HHg was significantly different (p = 0.00001) between riverine (12.1 \u00b5g\u00b7g\u22121), rural (7.82 \u00b5g\u00b7g\u22121), urban (5.4 \u00b5g\u00b7g\u22121), and tin miner (4.5 \u00b5g\u00b7g\u22121) groups studied. The same trend (of medians) was observed for newborns\u2019 HHg which also showed significant differences between riverine (3.0 \u00b5g\u00b7g\u22121), rural (2.0 \u00b5g\u00b7g\u22121), urban  (1.5 \u00b5g\u00b7g\u22121), and tin miner (0.8 \u00b5g\u00b7g\u22121) groups. The correlation between maternal and newborn HHg was statistically significant in the riverine (r = 0.8952; p = 0.0001), urban  (r = 0.6744; p = 0.0001), and rural (r = 0.8416; p = 0.0001) groups but not in the mother-infant pairs in the tin miner group (r = 0.0638; p = 0.2752). Birth weight was significantly different among groups but did not show a pattern consistent with that of fish consumption (and HHg). A multiple regression analysis showed that only family income and gestational age had a significant impact on birth weight. Conclusions: Maternal HHg is an important biomarker of maternal fish consumption and of methylmercury exposure during pregnancy. However, in these Amazonian groups, only maternal education and gestational age seemed to affect birth weight positively.<\/jats:p>","DOI":"10.3390\/ijerph10062150","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T12:17:33Z","timestamp":1369743453000},"page":"2150-2163","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Fish Consumption during Pregnancy, Mercury Transfer, and Birth Weight along the Madeira River Basin in Amazonia"],"prefix":"10.3390","volume":"10","author":[{"given":"Rejane","family":"Marques","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro, Campus Maca\u00e9, CEP 27930-560, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Bernardi","sequence":"additional","affiliation":[{"name":"University of Bras\u00edlia, Bras\u00edlia, CEP 0919-970, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"D\u00f3rea","sequence":"additional","affiliation":[{"name":"University of Bras\u00edlia, Bras\u00edlia, CEP 0919-970, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katiane","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Federal University of Rond\u00f4nia, Porto Velho, CEP 76801-059, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00e9lia","family":"Bueno","sequence":"additional","affiliation":[{"name":"Federal University of Rond\u00f4nia, Porto Velho, CEP 76801-059, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, CEP 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Malm","sequence":"additional","affiliation":[{"name":"Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, CEP 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ecoenv.2003.12.008","article-title":"Cassava cyanogens and fish mercury are high but safely consumed in the diet of native Amazonians","volume":"57","year":"2004","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Barbieri, F.L., and Gardon, J. (2009). Hair mercury levels in Amazonian populations: Spatial distribution and trends. Int. J. Health Geogr., 8.","DOI":"10.1186\/1476-072X-8-71"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijheh.2006.08.001","article-title":"Maternal mercury exposure and neuro-motor development in breastfed infants from Porto Velho (Amazon), Brazil","volume":"210","author":"Marques","year":"2007","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Vieira, S.M., de Almeida, R., Holanda, I.B., Mussy, M.H., Galv\u00e3o, R.C., Crispim, P.T.,  D\u00f3rea, J.G., and Bastos, W.R. (2013). Total and methyl-mercury in hair and milk of mothers living in the city of Porto Velho and in villages along the Rio Madeira, Amazon, Brazil. Int. J. Hyg .Environ. Health.","DOI":"10.1016\/j.ijheh.2012.12.011"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/ije\/27.2.242","article-title":"Length and ponderal index at birth: Associations with mortality, hospitalizations, development and post-natal growth in Brazilian infants","volume":"27","author":"Morris","year":"1998","journal-title":"Int. J. Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Guldner, L., Monfort, C., Rouget, F., Garlantezec, R., and Cordier, S. (2007). Maternal fish and shellfish intake and pregnancy outcomes: A prospective cohort study in Brittany, France. Environ. Health, 6.","DOI":"10.1186\/1476-069X-6-33"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijheh.2006.02.004","article-title":"Fish consumption and time to pregnancy in Japanese women","volume":"209","author":"Arakawa","year":"2006","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0048-9697(86)90015-X","article-title":"Mercury in neonatal scalp hair","volume":"57","author":"Sikorski","year":"1986","journal-title":"Sci. Total Environ."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1016\/j.scitotenv.2010.07.079","article-title":"Perinatal lead and mercury exposure in Austria","volume":"408","author":"Gundacker","year":"2010","journal-title":"Sci. Total Environ."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1017\/S0007114510001947","article-title":"Prenatal mercury contamination: Relationship with maternal seafood consumption during pregnancy and fetal growth in the \u201cEDEN mother-child\u201d cohort","volume":"104","author":"Huel","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1017\/S136898001000248X","article-title":"Hydroelectric reservoir inundation (Rio Madeira Basin, Amazon) and changes in traditional lifestyle: Impact on growth and neurodevelopment of pre-school children","volume":"14","author":"Marques","year":"2011","journal-title":"Public Health Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00244-011-9697-4","article-title":"Role of methylmercury exposure (from fish consumption) on growth and neurodevelopment of children under 5 years of age living in a transitioning (tin-mining) area of the western Amazon, Brazil","volume":"62","author":"Marques","year":"2012","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00128-012-0621-z","article-title":"Amazon forest fires between 2001 and 2006 and birth weight in Porto Velho","volume":"89","author":"Prass","year":"2012","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_14","unstructured":"Siegel, S., and Castellan, N.J. (1988). Nonparametric Statistics for the Behavioral Sciences, McGraw-Hill. [2nd Ed.]."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.scitotenv.2008.06.017","article-title":"Persistent, bioaccumulative and toxic substances in fish: Human health considerations","volume":"400","year":"2008","journal-title":"Sci. Total Environ."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.envint.2010.07.001","article-title":"Mercury and DDT exposure risk to fish-eating human populations in Amazon","volume":"37","author":"Rabitto","year":"2011","journal-title":"Environ. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-069X-12-3","article-title":"Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention","volume":"12","author":"Bellanger","year":"2013","journal-title":"Environ. Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1365-3016.2007.00863.x","article-title":"Birthweight distributions by gestational age: Comparison of LMP-based and ultrasound-based estimates of gestational age using data from the Swedish Birth Registry","volume":"21","author":"Haglund","year":"2007","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1590\/S0102-311X2006000600002","article-title":"Risk factors for repetition of low birth weight, intrauterine growth retardation, and prematurity in subsequent pregnancies: A systematic review","volume":"22","author":"Sclowitz","year":"2006","journal-title":"Cad. Saude Publica"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/jech.2007.061473","article-title":"Social inequality in fetal growth: A comparative study of Denmark, Finland, Norway and Sweden in the period 1981\u20132000","volume":"62","author":"Mortensen","year":"2008","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1365-3016.2009.01023.x","article-title":"Explaining educational inequalities in birthweight. The Generation R Study","volume":"23","author":"Jansen","year":"2009","journal-title":"Paediatr. Perinat. Epidemiol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/ije\/dyq069","article-title":"Mother\u2019s educational level and fetal growth: The genesis of health inequalities","volume":"39","author":"Silva","year":"2010","journal-title":"Int. J. Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.envres.2007.10.002","article-title":"Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population","volume":"106","author":"Sakamoto","year":"2008","journal-title":"Environ. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/jat\/21.2.149","article-title":"The determination of mercury and selenium in maternal and neonatal scalp hair by inductively coupled plasma-mass spectrometry","volume":"21","author":"Razagui","year":"1997","journal-title":"J. Anal. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1471-0528.2003.02257.x","article-title":"Maternal and neonatal hair mercury concentrations: The effect of dental amalgam","volume":"110","author":"Lindow","year":"2003","journal-title":"BJOG"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00244-008-9213-7","article-title":"Prenatal and early childhood exposure to mercury and methylmercury in Spain, a high-fish-consumer country","volume":"56","author":"Delgado","year":"2009","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1081\/CLT-50404","article-title":"Mercury exposure of mothers and newborns in Surinam: A pilot study","volume":"43","author":"Mohan","year":"2005","journal-title":"Clin. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF01686068","article-title":"Mercury levels in human maternal and neonatal blood, hair and milk","volume":"18","author":"Fujita","year":"1977","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.1021\/jf0100393","article-title":"Composition of total, neutral and phospholipids in mapar\u00e1 (Hypophtalmus sp.) from the Brazilian Amazonian area","volume":"49","author":"Inhamuns","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_30","unstructured":"(2004). Sixty-first Meeting of the Joint FAO\/WHO Expert Committee on Food Additives Held in Rome, 10\u201319 June 2003, World Health Organ Techn Rep Ser 922, World Health Organization."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s002449900291","article-title":"Concentration of mercury in hair of indigenous mothers and infants from the Amazon basin","volume":"34","author":"Barbosa","year":"1998","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1006\/enrs.2000.4050","article-title":"Linear regression models of methyl mercury exposure during prenatal and early postnatal life among riverside people along the upper Madeira river, Amazon","volume":"83","author":"Boischio","year":"2000","journal-title":"Environ. Res."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/10\/6\/2150\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:47:01Z","timestamp":1760219221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/10\/6\/2150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,28]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6]]}},"alternative-id":["ijerph10062150"],"URL":"https:\/\/doi.org\/10.3390\/ijerph10062150","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,28]]}}}