{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:56:55Z","timestamp":1791313015784,"version":"4.3.1"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>A marked increase in canine leptospirosis was observed in Switzerland over  10 years with a peak incidence of 28.1 diagnosed cases\/100,000 dogs\/year in the most affected canton. With 95% affected dogs living at altitudes &lt;800 m, the disease presented  a seasonal pattern associated with temperature (r2 0.73) and rainfall (r2 0.39), &gt;90% cases being diagnosed between May and October. The increasing yearly incidence however was only weakly correlated with climatic data including number of summer (r2 0.25) or rainy days (r2 0.38). Serovars Australis and Bratislava showed the highest seropositivity rates with 70.5% and 69.1%, respectively. Main clinical manifestations included renal (99.6%), pulmonary (76.7%), hepatic (26.0%), and hemorrhagic syndromes (18.2%), leading to  a high mortality rate (43.3%). Similar to the human disease, liver involvement had the strongest association with negative outcome (OR 16.3). Based on these data, canine leptospirosis presents similar features and severity as the human infection for which it therefore can be considered a model. Its re-emergence in a temperate country with very high incidence rates in canines should thus be viewed as a warning and emphasize the need for increased awareness in other species.<\/jats:p>","DOI":"10.3390\/ijerph110707242","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T11:47:18Z","timestamp":1405511238000},"page":"7242-7260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Increasing Incidence of Canine Leptospirosis in Switzerland"],"prefix":"10.3390","volume":"11","author":[{"given":"Andrea","family":"Major","sequence":"first","affiliation":[{"name":"Department of Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern,  L\u00e4nggassstrasse 128, CH-3001 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Schweighauser","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern,  L\u00e4nggassstrasse 128, CH-3001 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Francey","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern,  L\u00e4nggassstrasse 128, CH-3001 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: A zoonotic disease of global importance","volume":"3","author":"Bharti","year":"2003","journal-title":"Lancet Infect. 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