{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:07:55Z","timestamp":1778303275534,"version":"3.51.4"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Hypertension and smoking are related with oxidative stress (OS), which in turn reports on cellular aging. Zinc is an essential element involved in an individual\u2019s physiology. The aim of this study was to evaluate the relation of zinc levels in serum and urine with OS and cellular aging and its effect on the development of hypertension. In a Spanish sample with 1500 individuals, subjects aged 20\u201359 years were selected, whose zinc intake levels fell within the recommended limits. These individuals were classified according to their smoking habits and hypertensive condition. A positive correlation was found (Pearson\u2019s C = 0.639; p = 0.01) between Zn serum\/urine quotient and oxidized glutathione levels (GSSG). Finally, risk of hypertension significantly increased when the GSSG levels exceeded the 75 percentile; OR = 2.80 (95%CI = 1.09\u20137.18) and AOR = 3.06 (95%CI = 0.96\u20139.71). Low zinc levels in serum were related with OS and cellular aging and were, in turn, to be a risk factor for hypertension.<\/jats:p>","DOI":"10.3390\/ijerph120303060","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T11:30:24Z","timestamp":1426159824000},"page":"3060-3076","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation of Zinc with Oxidative Stress Biomarkers"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0785-1492","authenticated-orcid":false,"given":"Mar\u00eda","family":"Morales-Su\u00e1rez-Varela","sequence":"first","affiliation":[{"name":"Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia,  46100 Valencia, Spain"},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Instituto de Salud Carlos III,  28029 Madrid, Spain"},{"name":"Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Llopis-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia,  46100 Valencia, Spain"},{"name":"CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Instituto de Salud Carlos III,  28029 Madrid, Spain"},{"name":"Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Gonz\u00e1lez-Albert","sequence":"additional","affiliation":[{"name":"Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"L\u00f3pez-Izquierdo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Gonz\u00e1lez-Manzano","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Ch\u00e1ves","sequence":"additional","affiliation":[{"name":"Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociados (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Huerta-Biosca","sequence":"additional","affiliation":[{"name":"Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia,  46100 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Martin-Escudero","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/heartjnl-2011-300741","article-title":"Resistant hypertension","volume":"98","author":"Fagard","year":"2012","journal-title":"Heart"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/S0140-6736(12)61766-8","article-title":"A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk clusters in 21 regions, 1990\u20132010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"ref_3","unstructured":"World Health Organization (2013). 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