{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:34:28Z","timestamp":1774924468194,"version":"3.50.1"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:00:00Z","timestamp":1437091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Objective: To assess the high-sensitivity C-reactive protein (hs-CRP) levels and explore the risk factors for an elevated hs-CRP level. We also provide the clinical utility of CRP to identify subjects with metabolic syndrome (MetS). Methods: Data were drawn from a cross-sectional survey in China. Subjects were divided into three subgroups:  hs-CRP \u2264 1 mg\/L, 1 mg\/L &lt; hs-CRP \u2264 3 mg\/L and hs-CRP &gt; 3 mg\/L. Multiple linear regressions and logistic regression models were used. Results: In the Chinese population, 50.43% subjects had a low hs-CRP level, 30.21% subjects had an intermediate hs-CRP level and 19.36% subjects had an elevated hs-CRP level. Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and urinary albumin to creatinine ratio (ACR) were correlated with log-CRP. In multivariate analysis, relative risks of an elevated CRP level were 2.40 (95% CI 1.44\u20133.99, p = 0.001), 3.63 (95% CI 2.20\u20135.98, p &lt; 0.001), 4.23 (95% CI 2.51\u20137.11, p &lt; 0.001) and 6.23 (95% CI 3.45\u201311.26, p &lt; 0.001) for subjects with 1, 2, 3, or more than 3 MetS components, respectively. The accurate estimates of the area under the receiver operating characteristic of hs-CRP for MetS was 0.6954 (95% CI, 0.67\u20130.72). Conclusion: Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and ACR are correlated with log-CRP. The number of MetS components is a significant determinant of elevated CRP levels after adjusted for other potential confounders.<\/jats:p>","DOI":"10.3390\/ijerph120708228","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T11:18:48Z","timestamp":1437131928000},"page":"8228-8242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population"],"prefix":"10.3390","volume":"12","author":[{"given":"Mingxia","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China"},{"name":"Department of Nephrology, Huhhot First Hospital, Huhhot, Inner Mongolia 010010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China"},{"name":"Department of Nephrology, The First Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia 010010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China"},{"name":"Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hequn","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0140-6736(13)61097-1","article-title":"Rapid health transition in China, 1999\u20132010: Findings from the Global Burden of Disease Study 2010","volume":"381","author":"Yang","year":"2013","journal-title":"Lancet."},{"key":"ref_2","first-page":"2818","article-title":"European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invited experts)","volume":"109","author":"Graham","year":"2004","journal-title":"Circulation."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1253\/circj.CJ-08-0848","article-title":"Tentative cut point of high-sensitivity C-reactive protein for a component of metabolic syndrome in Japanese","volume":"73","author":"Oda","year":"2009","journal-title":"Circ. 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