{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:25:25Z","timestamp":1760243125722,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The acute phase of chronic periodontitis may occur even in patients during supportive periodontal therapy. However, the details are not fully understood. Since the natural environment, including meteorology affects human health, we hypothesized that weather conditions may affect occurrence of acute phase of chronic periodontitis. The aim of this study was to investigate the relationship between weather conditions and acute phase of chronic periodontitis in patients under supportive periodontal therapy. Patients who were diagnosed with acute phase of chronic periodontitis under supportive periodontal therapy during 2011\u20132013 were selected for this study. We performed oral examinations and collected questionnaires and meteorological data. Of 369 patients who experienced acute phase of chronic periodontitis, 153 had acute phase of chronic periodontitis without direct-triggered episodes. When using the autoregressive integrated moving average model of time-series analysis, the independent covariant of maximum hourly range of barometric pressure, maximum hourly range of temperature, and maximum daily wind speed were significantly associated with occurrence of acute phase of chronic periodontitis (p &lt; 0.05), and 3.1% of the variations in these occurrence over the study period were explained by these factors. Meteorological variables may predict occurrence of acute phase of chronic periodontitis.<\/jats:p>","DOI":"10.3390\/ijerph120809119","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T02:09:38Z","timestamp":1438913378000},"page":"9119-9130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between Acute Phase of Chronic Periodontitis and Meteorological Factors in the Maintenance Phase of Periodontal Treatment: A Pilot Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Noriko","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-5605","authenticated-orcid":false,"given":"Daisuke","family":"Ekuni","sequence":"additional","affiliation":[{"name":"Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Tomofuji","sequence":"additional","affiliation":[{"name":"Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan"},{"name":"Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Morita","sequence":"additional","affiliation":[{"name":"Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1600-0765.2006.00915.x","article-title":"Relationship between smoking status and periodontal conditions: Findings from national databases in Japan","volume":"41","author":"Ojima","year":"2006","journal-title":"J. Periodont. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-051X.2005.00821.x","article-title":"Generation of inflammatory stimuli: How bacteria set up inflammatory responses in the gingiva","volume":"32","author":"Madianos","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1902\/jop.2009.090185","article-title":"Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray","volume":"80","author":"Colombo","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","article-title":"The pathogenesis of human periodontitis: An introduction","volume":"14","author":"Page","year":"1997","journal-title":"Periodontology 2000"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000329670","article-title":"Innate cellular responses to the periodontal biofilm","volume":"15","author":"Benakanakere","year":"2012","journal-title":"Front. Oral Biol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"(2000). Parameter on periodontal maintenance. American Academy of Periodontology. J. Periodontol., 71, 849\u2013850.","DOI":"10.1902\/jop.2000.71.5-S.849"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1902\/jop.2003.74.9.1395","article-title":"Research, Science and Therapy Committee, American Academy of Periodontology. Position paper: Periodontal maintenance","volume":"74","author":"Cohen","year":"2003","journal-title":"J. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-051X.2008.01261.x","article-title":"The cost-effectiveness of supportive periodontal care for patients with chronic periodontitis","volume":"35","author":"Gaunt","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.5005\/jcdp-9-6-82","article-title":"Periodontal abscess during supportive periodontal therapy: A review of the literature","volume":"9","author":"Silva","year":"2008","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1034\/j.1600-051x.2000.027006377.x","article-title":"The periodontal abscess: A review","volume":"27","author":"Herrera","year":"2000","journal-title":"J. Clin. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1056\/NEJM199811053391904","article-title":"Seasonal changes in blood pressure in patients with end-stage renal disease treated with hemodialysis","volume":"339","author":"Mourad","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/01.HYP.0000199192.17126.d4","article-title":"Weather-related changes in 24-hour blood pressure profile: effects of age and implications for hypertension management","volume":"47","author":"Modesti","year":"2006","journal-title":"Hypertension"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/ajh.2008.177","article-title":"A synoptic approach to weather conditions discloses a relationship with ambulatory blood pressure in hypertensives","volume":"21","author":"Morabito","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/clc.4960080305","article-title":"Myocardial infarction and the weather: A significant positive correlation between the onset of heart infarct and 28 KHz atmospherics\u2014A pilot study","volume":"8","author":"Baumer","year":"1985","journal-title":"Clin. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ijcard.2004.12.047","article-title":"Relationships between weather and myocardial infarction: A biometeorological approach","volume":"105","author":"Morabito","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/occmed\/51.1.45","article-title":"Environmental factors and heatstroke","volume":"51","author":"Shanks","year":"2001","journal-title":"Occupational Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00484-005-0018-3","article-title":"Influence of weather on emergency transport events coded as stroke: Population-based study in Japan","volume":"50","author":"Ohshige","year":"2006","journal-title":"Int. J. Biometeorol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/emj.20.2.204","article-title":"Effect of weather on attendance with injury at a paediatric emergency department","volume":"20","author":"Macgregor","year":"2003","journal-title":"Emerg. Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00484-010-0303-7","article-title":"Relationships between sudden weather changes in summer and mortality in the Czech Republic, 1986\u20132005","volume":"54","year":"2010","journal-title":"Int. J. Biometeorol."},{"key":"ref_20","first-page":"434","article-title":"The correlation between the outbreaks of asthma attack and meteorologic parameters in Okinawa","volume":"47","author":"Hanashiro","year":"1998","journal-title":"Arerugi"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00484-008-0177-0","article-title":"Climate and prevalence of atopic eczema in 6- to 7-year-old school children in Spain. ISAAC Phase \u0428","volume":"52","author":"Alvarez","year":"2008","journal-title":"Int. J. Biometeorol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e13728","DOI":"10.1371\/journal.pone.0013728","article-title":"Do seasons have an influence on the incidence of depression? The use of an internet search engine query data as a proxy of human affect","volume":"5","author":"Yang","year":"2010","journal-title":"PLoS One"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/eurpub\/cku008","article-title":"Geographical and climatic factors and depression risk in the SUN project","volume":"24","author":"Gea","year":"2014","journal-title":"Eur. J. Public Health"},{"key":"ref_24","first-page":"1309","article-title":"The association between external weather conditions and pain and stiffness in women with rheumatoid arthritis","volume":"24","author":"Drane","year":"1997","journal-title":"J. Rheumatol."},{"key":"ref_25","first-page":"335","article-title":"Influence of weather conditions on rheumatic pain","volume":"29","author":"Strusberg","year":"2002","journal-title":"J. Rheumatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/rheumatology\/keq099","article-title":"Whether the weather influences pain? Results from the EpiFunD study in North West England","volume":"49","author":"Macfarlane","year":"2010","journal-title":"Rheumatology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1600-0528.2011.00667.x","article-title":"Chronic pain and weather conditions in patients suffering from temporomandibular disorders: a pilot study","volume":"40","author":"Edefonti","year":"2012","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.ejpain.2011.01.013","article-title":"Epidemiologic evidence of barometric pressure changes inducing increased reporting of oral pain","volume":"15","author":"Leitgeb","year":"2011","journal-title":"Eur. J. Pain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00484-012-0575-1","article-title":"The effects of daily weather variables on psychosis admissions to psychiatric hospitals","volume":"57","author":"McWilliams","year":"2013","journal-title":"Int. J. Biometeorol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Machida, T., Tomofuji, T., Ekuni, D., Yamane, M., Yoneda, T., Kawabata, Y., Kataoka, K., Tamaki, N., and Morita, M. (2014). Longitudinal relationship between plasma reactive oxygen metabolites and periodontal condition in the maintenance phase of periodontal treatment. Dis. Markers, 2014.","DOI":"10.1155\/2014\/489292"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann. Periodontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.micpath.2015.01.005","article-title":"Changes in antimicrobial susceptibility profile and prevalence of quinolone low-sensitive strains in subgingival plaque from acute periodontal lesions after systemic administration of sitafloxacin","volume":"79","author":"Tomita","year":"2015","journal-title":"Microb. Pathog."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2125.2011.04161.x","article-title":"The impact of antibiotic use on the incidence and resistance pattern of extended-spectrum beta-lactamase-producing bacteria in primary and secondary healthcare settings","volume":"74","author":"Aldeyab","year":"2012","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/prd.12022","article-title":"Acute periodontal lesions","volume":"65","author":"Herrera","year":"2014","journal-title":"Periodontology 2000"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1128\/IAI.74.2.1204-1214.2006","article-title":"Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting","volume":"74","author":"Zhou","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e115107","DOI":"10.1371\/journal.pone.0115107","article-title":"Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells","volume":"9","author":"Gokyu","year":"2014","journal-title":"PLoS One"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2249.2009.03920.x","article-title":"Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and escherichia coli lipopolysaccharide","volume":"156","author":"Barksby","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.archoralbio.2014.05.023","article-title":"Colonisation of gingival epithelia by subgingival biofilms in vitro: Role of \u201cred complex\u201d bacteria","volume":"59","author":"Thurnheer","year":"2014","journal-title":"Arch Oral Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.14219\/jada.archive.1978.0480","article-title":"Barodontalgia at 12,000 feet","volume":"97","author":"Hodges","year":"1978","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0140-6736(03)12443-9","article-title":"High atmospheric pressure and myopic shift in caisson workers","volume":"361","author":"Fledelius","year":"2003","journal-title":"Lancet"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1056\/NEJMoa062770","article-title":"Effect of aircraft-cabin altitude on passenger discomfort","volume":"357","author":"Muhm","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5664\/jcsm.27764","article-title":"Do weather-related ambient atmospheric-pressure changes influence sleep disordered breathing?","volume":"6","author":"Doherty","year":"2010","journal-title":"J. Clin. Sleep Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1160\/TH09-04-0214","article-title":"The influence of meteorological variables on the development of deep venous thrombosis","volume":"102","author":"Brown","year":"2009","journal-title":"Thromb. Haemost."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.joen.2008.12.004","article-title":"Barodontalgia","volume":"35","author":"Zadik","year":"2009","journal-title":"J. Endod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(00)01769-9","article-title":"Effects of lowering barometric pressure on guarding behavior, heart rate and blood pressure in a rat model of neuropathic pain","volume":"299","author":"Sato","year":"2001","journal-title":"Neurosci. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejpain.2009.02.004","article-title":"The inner ear is involved in the aggravation of nociceptive behavior induced by lowering barometric pressure of nerve injured rats","volume":"14","author":"Funakubo","year":"2010","journal-title":"Eur. J. Pain."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.anaerobe.2013.09.001","article-title":"The effects of stress hormones on growth of selected periodontitis related bacteria","volume":"24","author":"Jentsch","year":"2013","journal-title":"Anaerobe"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/aje\/kwn266","article-title":"Effects of cold weather on mortality: Results from 15 European cities within the PHEWE project","volume":"168","author":"Analitis","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1476-069X-8-40","article-title":"High ambient temperature and mortality: A review of epidemiologic studies from 2001 to 2008","volume":"8","author":"Basu","year":"2009","journal-title":"Environ. Health"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.envres.2011.05.022","article-title":"The short-term influence of temperature on daily mortality in the temperate climate of Montreal, Canada","volume":"111","author":"Goldberg","year":"2011","journal-title":"Environ. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.scitotenv.2014.03.048","article-title":"Short-term effects of air temperature on mortality and effect modification by air pollution in three cities of Bavaria, Germany: A time-series analysis","volume":"485\u2013486","author":"Breitner","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1289\/ehp.5957","article-title":"Temperature, air pollution, and hospitalization for cardiovascular diseases among elderly people in Denver","volume":"111","author":"Koken","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/jech.2004.028514","article-title":"Cold periods and coronary events: An analysis of populations worldwide","volume":"59","author":"Barnett","year":"2005","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/oemed-2011-100469","article-title":"Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals","volume":"69","author":"Hampel","year":"2012","journal-title":"Occup. Environ. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/EDE.0b013e31816a4325","article-title":"Air temperature and inflammatory responses in myocardial infarction survivors","volume":"19","author":"Schneider","year":"2008","journal-title":"Epidemiology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/j.1365-2222.2008.03033.x","article-title":"Effects of climate change on environmental factors in respiratory allergic diseases","volume":"38","author":"Cecchi","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/acr.22378","article-title":"Effect of weather on back pain: Results from a case-crossover study","volume":"66","author":"Steffens","year":"2014","journal-title":"Arthritis Care Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0011-8532(22)00449-9","article-title":"Periodontal emergencies","volume":"30","author":"Ahl","year":"1986","journal-title":"Dent. Clin. North Am."},{"key":"ref_59","first-page":"41","article-title":"Presentation and antimicrobial treatment of acute orofacial infections in general dental practice","volume":"166","author":"Lewis","year":"1989","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_60","first-page":"18","article-title":"The prevalence of periodontal abscess","volume":"73","author":"Gray","year":"1994","journal-title":"J. Indiana Dent. Assoc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1902\/jop.1996.67.2.93","article-title":"Long term evaluation of periodontal therapy (I). Response to 4 therapeutic modalities","volume":"67","author":"Kaldahl","year":"1996","journal-title":"J. Periodontol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1902\/jop.1997.68.10.963","article-title":"Tooth loss due to periodontal abscess: A retrospective study","volume":"68","author":"McLeod","year":"1997","journal-title":"J. Periodontol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/12\/8\/9119\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:50:16Z","timestamp":1760215816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/12\/8\/9119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,5]]},"references-count":62,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8]]}},"alternative-id":["ijerph120809119"],"URL":"https:\/\/doi.org\/10.3390\/ijerph120809119","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2015,8,5]]}}}