{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:50:49Z","timestamp":1773287449305,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71271042"],"award-info":[{"award-number":["71271042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>In the absence of effective vaccines, antiviral drugs and personal protective measures, such as voluntary self-isolation, have been a part of preparedness plans for the next influenza pandemic. We used a household model to assess the effect of voluntary self-isolation on outbreak control when antiviral drugs are not provided sufficiently early. We found that the early initiation of voluntary self-isolation can overcome the negative effects caused by a delay in antiviral drug distribution when enough symptomatic individuals comply with home confinement at symptom onset. For example, for the baseline household reproduction number RH0 = 2:5, if delays of one or two days occur between clinical symptom development and the start of antiviral prophylaxis, then compliance rates of q \u2265 0:41 and q \u2265 0:6, respectively, are required to achieve the same level of effectiveness as starting antiviral prophylaxis at symptom onset. When the time to beginning voluntary self-isolation after symptom onset increases from zero to two days, this strategy has a limited effect on reducing the transmission of influenza; therefore, this strategy should be implemented as soon as possible. In addition, the effect of voluntary self-isolation decreases substantially with the proportion of asymptomatic infections increasing.<\/jats:p>","DOI":"10.3390\/ijerph120809750","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T05:43:13Z","timestamp":1439876593000},"page":"9750-9767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Assessing the Role of Voluntary Self-Isolation in the Control of Pandemic Influenza Using a Household Epidemic Model"],"prefix":"10.3390","volume":"12","author":[{"given":"Qingxia","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Mathematical Sciences, University of Electronic Science and Technology of China, No. 2006, Xiyuan Avenue, West Hi-Tech Zone, Chengdu 611731, China"},{"name":"School of Sciences, Southwest Petroleum University, No.8, Xindu Avenue, Xindu District, Chengdu 610500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingcheng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Mathematical Sciences, University of Electronic Science and Technology of China, No. 2006, Xiyuan Avenue, West Hi-Tech Zone, Chengdu 611731, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/aje\/kwh092","article-title":"Containing pandemic influenza with antiviral agents","volume":"159","author":"Longini","year":"2004","journal-title":"Am. 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