{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:56:45Z","timestamp":1761663405560,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002631","name":"Gachon University","doi-asserted-by":"publisher","award":["GCU-2013-M057"],"award-info":[{"award-number":["GCU-2013-M057"]}],"id":[{"id":"10.13039\/501100002631","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Osteoporosis in males is becoming an important health concern in an aging society. The aim of this study was to investigate the associations between cadmium exposure and osteoporosis by considering the effect of obesity in aged males using a representative sample of the Korean population. Using the fourth and fifth Korea National Health and Nutrition Examination Survey data, 1098 males over 50 years of age were analyzed. The blood cadmium concentration was measured. The bone mineral density in the total hip, femur neck, and lumbar spine was measured using dual-energy X-ray absorptiometry. T-scores to determine the presence of osteoporosis were calculated using a Korean reference. Subjects were stratified into two groups according to obesity status (body mass index &lt;25 kg\/m2 and \u226525 kg\/m2). In comparison with obese subjects with blood cadmium &lt;1.00 \u03bcg\/L, those with blood cadmium &gt;1.50 \u03bcg\/L had odds ratios of 4.57 (95% confidence interval [CI] 1.49\u201314.01) and 5.71 (95% CI 1.99\u201316.38) at the femur neck and any site, respectively, after adjusting for potential confounders such as age, serum creatinine, vitamin D deficiency, smoking, alcohol drinking, and physical activity level. However, this association was not significant in non-obese males. In conclusion, the effect of cadmium on osteoporosis was different by obesity status in aged males.<\/jats:p>","DOI":"10.3390\/ijerph121012144","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T10:13:46Z","timestamp":1443435226000},"page":"12144-12157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Blood Cadmium Is Associated with Osteoporosis in Obese Males but Not in Non-Obese Males: The Korea National Health and Nutrition Examination Survey 2008\u20132011"],"prefix":"10.3390","volume":"12","author":[{"given":"Won-Jun","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Gachon University Gil Medical Center, Incheon 21565, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Hwan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Gachon University Gil Medical Center, Incheon 21565, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"The diagnosis of osteoporosis","volume":"9","author":"Kanis","year":"1994","journal-title":"J. Bone Miner. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1753-4887.2004.tb00019.x","article-title":"Caloric restriction and calcium\u2019s effect on bone metabolism and body composition in overweight and obese premenopausal women","volume":"62","author":"Radak","year":"2004","journal-title":"Nutr. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S8756-3282(02)00864-5","article-title":"Relationships among body mass, its components, and bone","volume":"31","author":"Reid","year":"2002","journal-title":"Bone"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002239900384","article-title":"Perspectives: Some roles of mechanical usage, muscle strength, and the mechanostat in skeletal physiology, disease, and research","volume":"62","author":"Frost","year":"1998","journal-title":"Calcif. Tissue. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1084\/jem.186.4.489","article-title":"Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts","volume":"186","author":"Kameda","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3390\/ijms16010378","article-title":"Oxidative stress in obesity: A critical component in human diseases","volume":"16","author":"Marseglia","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.archger.2012.05.004","article-title":"The association between homocysteine (HCY) and serum natural antioxidants in elderly bone mineral densitometry (BMD)","volume":"55","author":"Kuyumcu","year":"2012","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jbmr.224","article-title":"Long-term cadmium exposure and the association with bone mineral density and fractures in a population-based study among women","volume":"26","author":"Engstrom","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/jbmr.386","article-title":"Dietary cadmium exposure and fracture incidence among men: A population-based prospective cohort study","volume":"26","author":"Thomas","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.envres.2009.12.003","article-title":"The effects of low environmental cadmium exposure on bone density","volume":"110","author":"Jakubowski","year":"2010","journal-title":"Environ. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.taap.2009.05.015","article-title":"Cadmium osteotoxicity in experimental animals: Mechanisms and relationship to human exposures","volume":"238","author":"Bhattacharyya","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/15287390600882663","article-title":"Cadmium induces apoptosis in the human osteoblast-like cell line Saos-2","volume":"70","author":"Coonse","year":"2007","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.taap.2010.11.012","article-title":"The involvement of oxidative stress in the mechanisms of damaging cadmium action in bone tissue: A study in a rat model of moderate and relatively high human exposure","volume":"250","author":"Brzoska","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_15","unstructured":"KCDC (2009). Quality Control and Development of Standardization Manual for the Medical Laboratory Tests in the Nation-wide Health Survey of 2008 Year, Korea Center for Disease Control and Prevention."},{"key":"ref_16","unstructured":"KCDC (2010). Quality Control and Establishment of Reference Range for the Clinical Laboratory Tests in the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV-3), 2009, Korea Center for Disease Control and Prevention."},{"key":"ref_17","unstructured":"KCDC (2011). Quality Control and Examination of Measurement Traceability for the Clinical Laboratory Tests in the Nation-wide Health Survey of the year of 2010, Korea Center for Disease Control and Prevention."},{"key":"ref_18","unstructured":"KCDC (2012). Quality Control of the Clinical Laboratory for the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2, 2011), Korea Center for Disease Control and Prevention."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1592\/phco.23.2.190.32090","article-title":"Lack of diagnosis and treatment of osteoporosis in men and women after hip fracture","volume":"23","author":"Follin","year":"2003","journal-title":"Pharmacotherapy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1359\/jbmr.081116","article-title":"Bridging the osteoporosis quality chasm","volume":"24","author":"Curtis","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/jama.2009.50","article-title":"Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women","volume":"301","author":"Bliuc","year":"2009","journal-title":"JAMA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1172\/JCI10942","article-title":"Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men","volume":"106","author":"Riggs","year":"2000","journal-title":"J. Clin. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1210\/jc.2002-021036","article-title":"Differential effects of androgens and estrogens on bone turnover in normal men","volume":"88","author":"Leder","year":"2003","journal-title":"J. Clin. Endocrinol. Metable"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1359\/jbmr.080518","article-title":"Older men with low serum estradiol and high serum SHBG have an increased risk of fractures","volume":"23","author":"Mellstrom","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"ref_25","unstructured":"(1994). Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO study group. World Health Organ. Tech. Rep. Ser., 843, 1\u2013129."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s00223-002-1069-7","article-title":"A comparison study of the reference curves of bone mineral density at different skeletal sites in native Chinese, Japanese, and American Caucasian women","volume":"73","author":"Wu","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1471-2474-12-182","article-title":"Reference ranges for bone mineral density and prevalence of osteoporosis in Vietnamese men and women","volume":"12","author":"Nguyen","year":"2011","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3346\/jkms.2014.29.11.1514","article-title":"New reference data on bone mineral density and the prevalence of osteoporosis in Korean adults aged 50 years or older: The Korea National Health and Nutrition Examination Survey 2008\u20132010","volume":"29","author":"Lee","year":"2014","journal-title":"J. Korean Med. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1289\/ehp.8763","article-title":"Cadmium-induced effects on bone in a population-based study of women","volume":"114","author":"Akesson","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1359\/jbmr.2003.18.3.553","article-title":"Influence of environmental cadmium exposure on forearm bone density","volume":"18","author":"Wang","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"875249","DOI":"10.4061\/2011\/875249","article-title":"Calcium and vitamin D supplementation in men","volume":"2011","author":"Gielen","year":"2011","journal-title":"J. Osteoporos."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.etap.2009.04.010","article-title":"Effects of cadmium on osteoblasts and osteoclasts in vitro","volume":"28","author":"Chen","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0013-9351(02)00035-X","article-title":"Urinary cadmium excretion is correlated with calcaneal bone mass in Japanese women living in an urban area","volume":"91","author":"Honda","year":"2003","journal-title":"Environ. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/jbmr.22","article-title":"Occupational cadmium exposure and calcium excretion, bone density, and osteoporosis in men","volume":"25","author":"Nawrot","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"327","DOI":"10.5271\/sjweh.2404","article-title":"Biological half-time of cadmium in the blood of workers after cessation of exposure","volume":"9","author":"Jarup","year":"1983","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_36","first-page":"1","article-title":"Health effects of cadmium exposure\u2014A review of the literature and a risk estimate","volume":"24","author":"Jarup","year":"1998","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.envres.2015.03.008","article-title":"Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb","volume":"140","author":"Zhang","year":"2015","journal-title":"Environ. Res."},{"key":"ref_38","unstructured":"CDC (2015). Fourth Report on Human Exposure to Environmental Chemicals, Updated Tables. (February, 2015), Centers for Disease Control and Prevention."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1381\/096089203765887705","article-title":"Effect of weight loss on bone metabolism: Comparison of vertical banded gastroplasty and medical intervention","volume":"13","author":"Guney","year":"2003","journal-title":"Obes. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1210\/jc.2007-1473","article-title":"Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: A one-year randomized controlled trial","volume":"93","author":"Villareal","year":"2008","journal-title":"J. Clin. Endocrinol. Metable"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1210\/jc.2006-0572","article-title":"Relationship of obesity with osteoporosis","volume":"92","author":"Zhao","year":"2007","journal-title":"J. Clin. Endocrinol. Metable"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/ncprheum0070","article-title":"Mechanisms of disease: Is osteoporosis the obesity of bone?","volume":"2","author":"Rosen","year":"2006","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1210\/jc.2002-021496","article-title":"Marked decrease in plasma antioxidants in aged osteoporotic women: Results of a cross-sectional study","volume":"88","author":"Maggio","year":"2003","journal-title":"J. Clin. Endocrinol. Metable"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2147\/DMSO.S11920","article-title":"Is obesity in women protective against osteoporosis?","volume":"4","author":"Migliaccio","year":"2011","journal-title":"Diabetes Metab. Syndr. Obes."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/12\/10\/12144\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:49:23Z","timestamp":1760215763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/12\/10\/12144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":44,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10]]}},"alternative-id":["ijerph121012144"],"URL":"https:\/\/doi.org\/10.3390\/ijerph121012144","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2015,9,28]]}}}