{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:08:49Z","timestamp":1790633329820,"version":"4.1.0"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002641","name":"Konkuk University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>A significant decline of serum 25-hydroxyvitamin D concentration [25(OH)D] with increasing latitude has been reported only for Caucasians. To determine the association between serum 25(OH)D and geographic location and its impact on bone mineral density (BMD) in an Asian population, a total of 17,508 subjects (8910 men and 8598 women) from the 2008\u20132010 Korea National Health and Nutrition Examination Survey (KNHANES) were stratified into four age groups and analyzed for 25(OH)D and BMD according to geographic location (South, 33\u00b0 N\u201335\u00b0 N; Middle, 36\u00b0 N; North, 37\u00b0 N\u201338\u00b0 N). Mean 25(OH)D were 47.7 and 41.2 nmol\/L; calcium intake, 564.9 &amp; 442.3 mg\/d; femoral neck BMD, 0.829 &amp; 0.721 g\/cm2; and lumbar spine BMD, 0.960 &amp; 0.918 g\/cm2 for men and women, respectively. Both men and women living in the South had significantly higher 25(OH)D and femoral neck BMD for those \u226550 years old. Lumbar spine BMD was significantly higher in men \u226550 years old, and for women 10\u201329 &amp; 50\u201369 years old living in the South. A 1 or 2 degree difference in latitude has a significant effect on serum 25(OH)D and BMD in this low vitamin D status population. Thus, consideration of geographic location for a recommendation of vitamin D intake may be necessary.<\/jats:p>","DOI":"10.3390\/ijerph13020184","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T01:48:18Z","timestamp":1454464098000},"page":"184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Impact of Geographic Location on Vitamin D Status and Bone Mineral Density"],"prefix":"10.3390","volume":"13","author":[{"given":"Kyung-Jin","family":"Yeum","sequence":"first","affiliation":[{"name":"Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju-si 27478, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeng","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju-si 27478, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Seok","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon-si 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"V28","DOI":"10.1359\/jbmr.07s211","article-title":"Vitamin D and skin physiology: A D-lightful story","volume":"22","author":"Holick","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lu, H.K., Zhang, Z., Ke, Y.H., He, J.W., Fu, W.Z., Zhang, C.Q., and Zhang, Z.L. (2012). High prevalence of vitamin D insufficiency in China: Relationship with the levels of parathyroid hormone and markers of bone turnover. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047264"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3390\/nu6020729","article-title":"Vitamin D deficiency in India: Prevalence, causalities and interventions","volume":"6","author":"Ritu","year":"2014","journal-title":"Nutrients"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1007\/s00125-009-1554-x","article-title":"Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort","volume":"52","author":"Kirii","year":"2009","journal-title":"Diabetologia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1210\/jc.2010-2133","article-title":"Vitamin D insufficiency in Korea\u2014A greater threat to younger generation: The Korea National Health and Nutrition Examination Survey (KNHANES) 2008","volume":"96","author":"Choi","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bendik, I., Friedel, A., Roos, F.F., Weber, P., and Eggersdorfer, M. (2014). Vitamin D: A critical and essential micronutrient for human health. Front. Physiol., 5.","DOI":"10.3389\/fphys.2014.00248"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/jc.2010-2704","article-title":"The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know","volume":"96","author":"Ross","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3945\/ajcn.2008.27182","article-title":"Dietary calcium and magnesium intakes and the risk of type 2 diabetes: The Shanghai Women\u2019s Health Study","volume":"89","author":"Villegas","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","first-page":"269","article-title":"Dietary calcium intake\u2014A critical reappraisal","volume":"127","author":"Bhatia","year":"2008","journal-title":"Indian J. Med. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/jbmr.1790","article-title":"Impact of calcium and vitamin D insufficiencies on serum parathyroid hormone and bone mineral density: Analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHAENS IV-3, 2009 and V-1, 2010)","volume":"28","author":"Joo","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1210\/jc.2013-1480","article-title":"25-Hydroxyvitamin D, calcium intake, and bone mineral content in adolescents and young adults: Analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-2, 3, 2008-2009 and V-1, 2010)","volume":"98","author":"Joo","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.bone.2012.02.007","article-title":"Prevalence, awareness, and treatment of osteoporosis among Korean women: The Fourth Korea National Health and Nutrition Examination Survey","volume":"50","author":"Kim","year":"2012","journal-title":"Bone"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1210\/jc.2004-2364","article-title":"Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy","volume":"90","author":"Holick","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pbiomolbio.2006.02.004","article-title":"Who, what, where and when-influences on cutaneous vitamin D synthesis","volume":"92","author":"Webb","year":"2006","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3177\/jnsv.59.257","article-title":"The solar exposure time required for vitamin D3 synthesis in the human body estimated by numerical simulation and observation in Japan","volume":"59","author":"Miyauchi","year":"2013","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00198-008-0626-y","article-title":"Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: An ecologic meta-regression analysis","volume":"20","author":"Hagenau","year":"2009","journal-title":"Osteoporos. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/aje\/kwt446","article-title":"The contributions of solar ultraviolet radiation exposure and other determinants to serum 25-hydroxyvitamin D concentrations in Australian adults: The AusD Study","volume":"179","author":"Kimlin","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/php.12390","article-title":"Ultraviolet index and location are important determinants of vitamin D status in people with human immunodeficiency virus","volume":"91","author":"Klassen","year":"2015","journal-title":"Photochem. Photobiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.abb.2006.12.017","article-title":"Factors that influence the cutaneous synthesis and dietary sources of vitamin, D","volume":"460","author":"Chen","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jc.2007-1876","article-title":"Bone mineral density changes during the menopause transition in a multiethnic cohort of women","volume":"93","author":"Finkelstein","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3346\/jkms.2010.25.10.1473","article-title":"Milk intake and its association with metabolic syndrome in Korean: Analysis of the third Korea National Health and Nutrition Examination Survey (KNHANES III)","volume":"25","author":"Kwon","year":"2010","journal-title":"J. Korean Med. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4162\/nrp.2012.6.2.162","article-title":"Vitamin D deficiency is an independent risk factor for cardiovascular disease in Koreans aged >\/= 50 years: Results from the Korean National Health and Nutrition Examination Survey","volume":"6","author":"Park","year":"2012","journal-title":"Nutr. Res. Pract."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/13\/2\/184\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:18:41Z","timestamp":1760210321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/13\/2\/184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,2]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2]]}},"alternative-id":["ijerph13020184"],"URL":"https:\/\/doi.org\/10.3390\/ijerph13020184","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,2]]}}}