{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:43:14Z","timestamp":1789558994271,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Many epidemiological studies examining long-term health effects of exposure to air pollutants have characterized exposure by the outdoor air concentrations at sites that may be distant to subjects\u2019 residences at different points in time. The temporal and spatial mobility of subjects and the spatial scale of exposure assessment could thus lead to misclassification in the cumulative exposure estimation. This paper attempts to fill the gap regarding cumulative exposure assessment to air pollution at a fine spatial scale in epidemiological studies investigating long-term health effects. We propose a conceptual framework showing how major difficulties in cumulative long-term exposure assessment could be surmounted. We then illustrate this conceptual model on the case of exposure to NO2 following two steps: (i) retrospective reconstitution of NO2 concentrations at a fine spatial scale; and (ii) a novel approach to assigning the time-relevant exposure estimates at the census block level, using all available data on residential mobility throughout a 10- to 20-year period prior to that for which the health events are to be detected. Our conceptual framework is both flexible and convenient for the needs of different epidemiological study designs.<\/jats:p>","DOI":"10.3390\/ijerph13030319","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T11:10:18Z","timestamp":1458040218000},"page":"319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Conceptual Framework for the Assessment of Cumulative Exposure to Air Pollution at a Fine Spatial Scale"],"prefix":"10.3390","volume":"13","author":[{"given":"Kihal-Talantikite","family":"Wahida","sequence":"first","affiliation":[{"name":"School of Public Health (EHESP), Rennes, Cedex 35043, France"},{"name":"INSERM U1085 IRSET (Research Institute in Environmental and Occupational Health), Rennes, Cedex 35000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-7847","authenticated-orcid":false,"given":"Cindy","family":"Padilla","sequence":"additional","affiliation":[{"name":"School of Public Health (EHESP), Rennes, Cedex 35043, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zmirou-Navier","family":"Denis","sequence":"additional","affiliation":[{"name":"School of Public Health (EHESP), Rennes, Cedex 35043, France"},{"name":"INSERM U1085 IRSET (Research Institute in Environmental and Occupational Health), Rennes, Cedex 35000, France"},{"name":"Medical Department, Lorraine University, Nancy, Cedex 54052, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanchard","family":"Olivier","sequence":"additional","affiliation":[{"name":"School of Public Health (EHESP), Rennes, Cedex 35043, France"},{"name":"INSERM U1085 IRSET (Research Institute in Environmental and Occupational Health), Rennes, Cedex 35000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"G\u00e9raldine","sequence":"additional","affiliation":[{"name":"Air Quality Monitoring Associations (AASQA), Airparif, Paris 75004, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quenel","family":"Philippe","sequence":"additional","affiliation":[{"name":"School of Public Health (EHESP), Rennes, Cedex 35043, France"},{"name":"INSERM U1085 IRSET (Research Institute in Environmental and Occupational Health), Rennes, Cedex 35000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deguen","family":"S\u00e9verine","sequence":"additional","affiliation":[{"name":"School of Public Health (EHESP), Rennes, Cedex 35043, France"},{"name":"INSERM U1085 IRSET (Research Institute in Environmental and Occupational Health), Rennes, Cedex 35000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"ref_1","unstructured":"WHO Ambient (Outdoor) Air Quality and Health. 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