{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:59:36Z","timestamp":1790837976288,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:00:00Z","timestamp":1462406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Objective: To explore the spatial-temporal interaction effect within a Bayesian framework and to probe the ecological influential factors for tuberculosis. Methods: Six different statistical models containing parameters of time, space, spatial-temporal interaction and their combination were constructed based on a Bayesian framework. The optimum model was selected according to the deviance information criterion (DIC) value. Coefficients of climate variables were then estimated using the best fitting model. Results: The model containing spatial-temporal interaction parameter was the best fitting one, with the smallest DIC value (\u22124,508,660). Ecological analysis results showed the relative risks (RRs) of average temperature, rainfall, wind speed, humidity, and air pressure were 1.00324 (95% CI, 1.00150\u20131.00550), 1.01010 (95% CI, 1.01007\u20131.01013), 0.83518 (95% CI, 0.93732\u20130.96138), 0.97496 (95% CI, 0.97181\u20131.01386), and 1.01007 (95% CI, 1.01003\u20131.01011), respectively. Conclusions: The spatial-temporal interaction was statistically meaningful and the prevalence of tuberculosis was influenced by the time and space interaction effect. Average temperature, rainfall, wind speed, and air pressure influenced tuberculosis. Average humidity had no influence on tuberculosis.<\/jats:p>","DOI":"10.3390\/ijerph13050469","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T10:19:23Z","timestamp":1462529963000},"page":"469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Spatial-Temporal Epidemiology of Tuberculosis in Mainland China: An Analysis Based on Bayesian Theory"],"prefix":"10.3390","volume":"13","author":[{"given":"Kai","family":"Cao","sequence":"first","affiliation":[{"name":"School of Public Health, Capital Medical University, No. 10 Xitoutiao, You\u2019anmen Wai, Fengtai District, Beijing 100069, China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China"},{"name":"Beijing Ophthalmology &amp; Visual Science Key Lab., Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health, Capital Medical University, No. 10 Xitoutiao, You\u2019anmen Wai, Fengtai District, Beijing 100069, China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Capital Medical University, No. 10 Xitoutiao, You\u2019anmen Wai, Fengtai District, Beijing 100069, China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China"},{"name":"Department of Statistics and Information, Beijing Centers for Disease Control and Prevention, No 16, Hepingli Middle Street, Dongcheng District, Beijing 100013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Public Health, Capital Medical University, No. 10 Xitoutiao, You\u2019anmen Wai, Fengtai District, Beijing 100069, China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Tao","sequence":"additional","affiliation":[{"name":"School of Public Health, Capital Medical University, No. 10 Xitoutiao, You\u2019anmen Wai, Fengtai District, Beijing 100069, China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingrong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, Capital Medical University, No. 10 Xitoutiao, You\u2019anmen Wai, Fengtai District, Beijing 100069, China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahara","family":"Gehendra","sequence":"additional","affiliation":[{"name":"School of Public Health, Capital Medical University, No. 10 Xitoutiao, You\u2019anmen Wai, Fengtai District, Beijing 100069, China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Public Health, Capital Medical University, No. 10 Xitoutiao, You\u2019anmen Wai, Fengtai District, Beijing 100069, China"},{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1186\/1471-2458-12-885","article-title":"The spatial epidemiology of tuberculosis in Linyi City, China, 2005\u20132010","volume":"12","author":"Wang","year":"2012","journal-title":"BMC Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.5588\/ijtld.13.0144","article-title":"Analysis of the economic burden of diagnosis and treatment of tuberculosis patients in rural China","volume":"17","author":"Pan","year":"2013","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3390\/ijerph120201425","article-title":"A spatial, social and environmental study of tuberculosis in China using statistical and GIS technology","volume":"12","author":"Sun","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhang, X., Jia, H., Liu, F., Pan, L., Xing, A., Gu, S., Du, B., Sun, Q., Wei, R., and Zhang, Z. (2013). Prevalence and Risk Factors for Latent Tuberculosis Infection among Health Care Workers in China: A Cross-Sectional Study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066412"},{"key":"ref_5","first-page":"129","article-title":"Study on the risk factors of tuberculosis in four cities and provinces in China","volume":"34","author":"Zhu","year":"2013","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/1471-2334-12-354","article-title":"Risk factors and clinical phenotypes of Beijing genotype strains in tuberculosis patients in China","volume":"12","author":"Pang","year":"2012","journal-title":"BMC Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1744-313X.2011.01079.x","article-title":"Polymorphisms of NOD2 and the risk of tuberculosis: A validation study in the Chinese population","volume":"39","author":"Pan","year":"2012","journal-title":"Int. J. Immunogenet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.5588\/ijtld.15.0126","article-title":"Prevalence of tuberculosis in prisons: Risk factors and molecular epidemiology","volume":"19","author":"Valenca","year":"2015","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Dhanaraj, B., Papanna, M.K., Adinarayanan, S., Vedachalam, C., Sundaram, V., Shanmugam, S., Sekar, G., Menon, P.A., Wares, F., and Swaminathan, S. (2015). Prevalence and risk factors for adult pulmonary tuberculosis in a metropolitan city of South India. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124260"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wang, X., Yang, Z., Fu, Y., Zhang, G., Wang, X., Zhang, Y., and Wang, X. (2014). Insight to the Epidemiology and Risk Factors of Extra pulmonary Tuberculosis in Tianjin, China during 2006\u20132011. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112213"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12889-015-1376-3","article-title":"Tuberculosis risk factors among tuberculosis patients in Kampala, Uganda: Implications for tuberculosis control","volume":"15","author":"Kirenga","year":"2015","journal-title":"BMC Public Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12879-015-0771-9","article-title":"Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations","volume":"15","author":"Zhang","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.tube.2014.08.014","article-title":"Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China","volume":"94","author":"Yang","year":"2014","journal-title":"Tuberculosis (Edinb.)"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1186\/s12879-014-0592-2","article-title":"Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis","volume":"14","author":"Feng","year":"2014","journal-title":"BMC Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijid.2014.03.1395","article-title":"Correlation analysis between single nucleotide polymorphisms of pulmonary surfactant protein A gene and pulmonary tuberculosis in the Han population in China","volume":"26","author":"Yang","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/eurpub\/ckt105","article-title":"Prevalence of latent tuberculosis infection and its risk factors in schoolchildren and adolescents in Shanghai, China","volume":"23","author":"Hu","year":"2013","journal-title":"Eur. J. Public Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/147323001204000205","article-title":"Social behaviour risk factors for drug resistant tuberculosis in mainland China: A meta-analysis","volume":"40","author":"Zhao","year":"2012","journal-title":"J. Int. Med. Res."},{"key":"ref_18","first-page":"752709","article-title":"Determinants of Pulmonary Tuberculosis among Inmates at Mangaung Maximum Correctional Facility in Bloemfontein, South Africa","volume":"2015","author":"Nyasulu","year":"2015","journal-title":"Tuberc. Res. Treat."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jegh.2015.02.004","article-title":"Analyzing seasonality of tuberculosis across Indian states and union territories","volume":"5","author":"Narula","year":"2015","journal-title":"J. Epidemiol. Glob. Health"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Liu, Y.X., Pang, C.K., Liu, Y., Sun, X.B., Li, X.X., Jiang, S.W., and Xue, F. (2015). Association between Multidrug-Resistant Tuberculosis and Risk Factors in China: Applying Partial Least Squares Path Modeling. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128298"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"23620","DOI":"10.3402\/gha.v7.23620","article-title":"Exploration of ecological factors related to the spatial heterogeneity of tuberculosis prevalence in P. R. China","volume":"7","author":"Li","year":"2014","journal-title":"Glob. Health Action"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/aje\/kwu250","article-title":"Spatial-temporal modeling of neighborhood sociodemographic characteristics and food stores","volume":"181","author":"Lamichhane","year":"2015","journal-title":"Am. J. Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Naithani, K.J., Baldwin, D.C., Gaines, K.P., Lin, H., and Eissenstat, D.M. (2013). Spatial distribution of tree species governs the spatio-temporal interaction of leaf area index and soil moisture across a forested landscape. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058704"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Bauer, C., Wakefield, J., Rue, H., Self, S., Feng, Z., and Wang, Y. (2015). Bayesian penalized spline models for the analysis of spatio-temporal count data. Stat. Med.","DOI":"10.1002\/sim.6785"},{"key":"ref_25","unstructured":"National Population and Health Science Data Sharing Platform [DB\/OL]. Available online: http:\/\/www. phsciencedata.cn."},{"key":"ref_26","unstructured":"China Meteorological Data Sharing Service System [DB\/OL], Available online: http:\/\/cdc.cma.gov.cn."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrg2825","article-title":"Tackling the widespread and critical impact of batch effects in high-throughput data","volume":"11","author":"Leek","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1097\/QAD.0000000000000821","article-title":"Likely effect of the 2014 Ebola epidemic on HIV care in Liberia","volume":"29","author":"Loubet","year":"2015","journal-title":"AIDS"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1017\/S0950268815000667","article-title":"Impact of influenza vaccination on respiratory illness rates in children attending private boarding schools in England, 2013\u20132014: A cohort study","volume":"143","author":"Brousseau","year":"2015","journal-title":"Epidemiol. Infect."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.ajic.2015.06.013","article-title":"Evaluation and quantitative microbial risk assessment of a unique antimicrobial agent for hospital surface treatment","volume":"43","author":"Perez","year":"2015","journal-title":"Am. J. Infect. Control"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/EDE.0b013e3182878e19","article-title":"A sign of super spreading in tuberculosis: Highly skewed distribution of genotypic cluster sizes","volume":"24","author":"Ypma","year":"2013","journal-title":"Epidemiology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jinf.2013.07.021","article-title":"Evaluation of a national microbiological surveillance system to inform automated outbreak detection","volume":"67","author":"Freeman","year":"2013","journal-title":"J. Infect."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/biom.12237","article-title":"A one-step-ahead pseudo-DIC for comparison of Bayesian state-space models","volume":"70","author":"Millar","year":"2014","journal-title":"Biometrics"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4310\/SII.2014.v7.n4.a9","article-title":"Bayesian Case-deletion Model Complexity and Information Criterion","volume":"7","author":"Zhu","year":"2014","journal-title":"Stat. Interface"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"China Tuberculosis Control Collaboration (2004). The effect of tuberculosis control in China. Lancet, 364, 417\u2013422.","DOI":"10.1016\/S0140-6736(04)16764-0"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.camwa.2015.06.006","article-title":"Bayesian spatio-temporal prediction of cancer dynamics","volume":"70","author":"Vlad","year":"2015","journal-title":"Comput. Math. Appl."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jog.2015.04.002","article-title":"Temporal\u2013spatial evolution of low-SiO2 volcanism in the Pleistocene West Eifel volcanic field (West Germany) and relationship to upwelling asthenosphere","volume":"88","author":"Mertz","year":"2015","journal-title":"J. Geodyn."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.proenv.2011.02.006","article-title":"The spatio-temporal diffusion of Pandemic Influenza (H1N1) 2009 in Hong Kong","volume":"3","author":"Wong","year":"2011","journal-title":"Procedia Environ. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jegh.2015.07.007","article-title":"Seasonality and trend analysis of tuberculosis in Lahore, Pakistan from 2006 to 2013","volume":"5","author":"Khaliq","year":"2015","journal-title":"J. Epidemiol. Glob. Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.inhe.2009.06.006","article-title":"Seasonal variation among tuberculosis suspects in four countries","volume":"1","author":"Mabaera","year":"2009","journal-title":"Int. Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.foodcont.2015.09.042","article-title":"Temperature and pH influence the susceptibility of Salmonella Typhimurium to nisin combined with EDTA","volume":"61","author":"Mantovani","year":"2016","journal-title":"Food Control"},{"key":"ref_43","first-page":"79","article-title":"Advanced tuberculosis in an African buffalo (Syncerus caffer Sparrman)","volume":"65","author":"Keet","year":"1994","journal-title":"J. S. Afr. Vet. Assoc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/1117-1936.170300","article-title":"Seasonal variation in hospitalisation for respiratory diseases in the tropical rain forest of South Western Nigeria","volume":"18","author":"Desalu","year":"2011","journal-title":"Niger. Postgrad. Med. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ajic.2011.02.014","article-title":"Room ventilation and the risk of airborne infection transmission in 3 health care settings within a large teaching hospital","volume":"39","author":"Knibbs","year":"2011","journal-title":"Am. J. Infect. Control."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/13\/5\/469\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:23:19Z","timestamp":1760210599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/13\/5\/469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,5]]},"references-count":45,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5]]}},"alternative-id":["ijerph13050469"],"URL":"https:\/\/doi.org\/10.3390\/ijerph13050469","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,5]]}}}