{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:20:15Z","timestamp":1760242815578,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T00:00:00Z","timestamp":1470441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Provincial Health Department","award":["Y2013051"],"award-info":[{"award-number":["Y2013051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Epidemics of HIV among men who have sex with men (MSM) are major public health concerns in most parts of China. This study examined the trends in HIV incidence and associated factors among MSM in Jiangsu Province. Five consecutive cross-sectional surveys were conducted among MSM from 2011 to 2015 in eight cities throughout Jiangsu Province. Participants were recruited from MSM venues or via the internet. Demographic and behavioral data were collected through HIV bio-behavioral surveys. Blood specimens were collected to test for HIV and syphilis. HIV incidence was estimated by the IgG-capture BED-EIA (BED) method and a chi-square trend test was used to compare differences over the years. Multivariate logistic regression analysis was used to identify factors associated with recent infection. A total of 2433, 2678, 2591, 2610 and 2541 participants were enrolled in 2011, 2012, 2013, 2014 and 2015, respectively. HIV incidence increased from 5.10% in 2011 to 6.62% in 2015 (p = 0.025). MSM who had an education level of junior high school or less (aOR = 1.472, p = 0.018), engaged in condomless anal sex in the past 6 months (aOR = 2.389, p &lt; 0.001), did not have an HIV test in the past 12 months (aOR = 3.215, p &lt; 0.001), and were currently infected with syphilis (aOR = 2.025, p = 0.001) were likely to be recently infected with HIV. HIV incidence is increasing among MSM in Jiangsu Province, China. Condom usage and HIV testing promotion should be prioritized when attempting to reduce HIV transmission among MSM in China.<\/jats:p>","DOI":"10.3390\/ijerph13080795","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T10:14:38Z","timestamp":1470651278000},"page":"795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increasing HIV Incidence among Men Who Have Sex with Men in Jiangsu Province, China: Results from Five Consecutive Surveys, 2011\u20132015"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-7773","authenticated-orcid":false,"given":"Haiyang","family":"Hu","sequence":"first","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingen","family":"Shi","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengfeng","family":"Fu","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiping","family":"Huan","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,8,6]]},"reference":[{"unstructured":"Ministry of Health of the People\u2019s Republic of China, Joint United Nations Programme on HIV\/AIDS, and World Health Organization (2011). 2011 Estimates for the HIV\/AIDS Epidemic in China, Available online: http:\/\/www.chinaaids.cn\/fzdt\/zxdd\/201201\/W020141216427590954445.pdf.","key":"ref_1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/cid\/cit210","article-title":"HIV and syphilis prevalence among men who have sex with men: A cross-sectional survey of 61 cities in China","volume":"57","author":"Wu","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","first-page":"542","article-title":"Trend on HIV prevalence and risk behaviors among men who have sex with men in China from 2010 to 2013","volume":"35","author":"Li","year":"2014","journal-title":"Chin. J. Epidemiol."},{"key":"ref_4","first-page":"602719","article-title":"The dynamic trends of HIV prevalence, risks, and prevention among men who have sex with men in Chongqing, China","volume":"2014","author":"Zeng","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_5","first-page":"1857","article-title":"HIV prevalence and influencing factors analysis of sentinel surveillance among men who have sex with men in China, 2003\u20132011","volume":"125","author":"Wang","year":"2012","journal-title":"Chin. Med. J. (Engl.)"},{"unstructured":"Jiangsu Provincial Commission of Health and Family Planning The Provincial Progress of HIV\/AIDS Control and Prevention, Available online: http:\/\/www.jswst.gov.cn\/jsswshjhsywyh\/xwzx\/snxw\/2015\/11\/30141742234.html.","key":"ref_6"},{"key":"ref_7","first-page":"637","article-title":"Study on infection rate of HIV\/syphilis among men who have sex with men in a balneary","volume":"27","author":"Cao","year":"2007","journal-title":"Acta Univ. Med. Nanjing"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/QAI.0b013e318239c947","article-title":"Long-chain peer referral of men who have sex with men: A novel approach to establish and maintain a cohort to measure HIV incidence, Nanjing, China","volume":"59","author":"Yan","year":"2012","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1093\/cid\/ciu175","article-title":"Worsening epidemic of HIV and syphilis among men who have sex with men in Jiangsu Province, China","volume":"58","author":"Yang","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_10","first-page":"510","article-title":"Application of laboratory methods for estimation of HIV-1 incidence","volume":"121","author":"Parekh","year":"2005","journal-title":"Indian J. Med. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/088922202753472874","article-title":"Quantitative detection of increasing HIV type 1 antibodies after seroconversion: A simple assay for detecting recent HIV infection and estimating incidence","volume":"18","author":"Parekh","year":"2002","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/jama.300.5.520","article-title":"Estimation of HIV incidence in the United States","volume":"300","author":"Hall","year":"2008","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1097\/01.aids.0000304696.62508.8a","article-title":"HIV-1 incidence estimates using IgG-capture BED-enzyme immunoassay from surveillance sites of injection drug users in three cities of China","volume":"21","author":"Jiang","year":"2007","journal-title":"AIDS"},{"unstructured":"Chinese Center for Disease Control and Prevention (2011). Operation Manual of the National AIDS Sentinel Surveillance Programme.","key":"ref_14"},{"unstructured":"Chinese Center for Disease Control and Prevention (2013). Operation Manual of Recent HIV Infection Surveillance Programme (2013).","key":"ref_15"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/OLQ.0b013e3181d13c59","article-title":"HIV incidence and associated factors in a cohort of men who have sex with men in Nanjing, China","volume":"37","author":"Yang","year":"2010","journal-title":"Sex. Transm. Dis."},{"key":"ref_17","first-page":"663","article-title":"Study on the incidence of HIV and associated risk factors through a prospective cohort among men who have sex with men in Beijing, China","volume":"33","author":"Li","year":"2012","journal-title":"Chin. J. Epidemiol."},{"key":"ref_18","first-page":"617","article-title":"Estimation of new HIV-1 infection in high risk groups with BED-CEIA in Zhejiang, 2010\u20132012","volume":"28","author":"Guo","year":"2013","journal-title":"Dis. Surveill."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/ije\/dyr182","article-title":"Increasing prevalence of HIV and syphilis but decreasing rate of self-reported unprotected anal intercourse among men who had sex with men in Harbin, China: Results of five consecutive surveys from 2006 to 2010","volume":"41","author":"Wang","year":"2012","journal-title":"Int. J. Epidemiol."},{"doi-asserted-by":"crossref","unstructured":"Wang, X., Lan, G., Shen, Z., Vermund, S.H., Zhu, Q., Chen, Y., Khoshnood, K., Wu, Z., and Tang, Z. (2014). HIV and syphilis prevalence trends among men who have sex with men in Guangxi, China: Yearly cross-sectional surveys, 2008\u20132012. BMC Infect. Dis., 14.","key":"ref_20","DOI":"10.1186\/1471-2334-14-367"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1080\/09540121.2012.668171","article-title":"Empowering HIV testing as a prevention tool: Targeting interventions for high-risk men who have sex with men","volume":"24","author":"Lorente","year":"2012","journal-title":"AIDS Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0140-6736(08)61697-9","article-title":"Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for eliminating HIV transmission: A mathematical model","volume":"373","author":"Granich","year":"2009","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJMoa1105243","article-title":"Prevention of HIV-1 infection with early antiretroviral therapy","volume":"365","author":"Cohen","year":"2011","journal-title":"N. Engl. J. Med."},{"doi-asserted-by":"crossref","unstructured":"Zhong, F., Liang, B., Xu, H., Cheng, W., Fan, L., Han, Z., Liang, C., Gao, K., Mai, H., and Qin, F. (2014). Increasing HIV and decreasing syphilis prevalence in a context of persistently high unprotected anal intercourse, six consecutive annual surveys among men who have sex with men in Guangzhou, China, 2008 to 2013. PLoS ONE, 9.","key":"ref_24","DOI":"10.1371\/journal.pone.0103136"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/OLQ.0b013e3181aac23d","article-title":"Prevalence and correlates of HIV and syphilis infections among men who have sex with men in Chongqing Municipality, China","volume":"36","author":"Xiao","year":"2009","journal-title":"Sex. Transm. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1521\/aeap.2006.18.1.33","article-title":"Lack of HIV testing and awareness of HIV infection among men who have sex with men, Beijing, China","volume":"18","author":"Choi","year":"2006","journal-title":"AIDS Educ. Prev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1080\/09540121.2013.824538","article-title":"Accessing HIV testing and treatment among men who have sex with men in China: A qualitative study","volume":"26","author":"Wei","year":"2014","journal-title":"AIDS Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/sti.2005.015040","article-title":"High rates of syphilis among STI patients are contributing to the spread of HIV-1 in India","volume":"82","author":"Reynolds","year":"2006","journal-title":"Sex. Transm. Infect"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1097\/01.olq.0000180466.62579.4b","article-title":"Syphilis epidemics and human immunodeficiency virus (HIV) incidence among men who have sex with men in the United States: Implications for HIV prevention","volume":"32","author":"Buchacz","year":"2005","journal-title":"Sex. Transm. Dis."},{"key":"ref_30","first-page":"476","article-title":"Overestimation of the South African HIV incidence using the BED IgG assay?","volume":"97","author":"Westreich","year":"2007","journal-title":"S. Afr. Med. J."},{"doi-asserted-by":"crossref","unstructured":"Simmons, R., Malyuta, R., Chentsova, N., Karnets, I., Murphy, G., Medoeva, A., Kruglov, Y., Yurchenko, A., Copas, A., and Porter, K. (2016). HIV incidence estimates using the limiting antigen avidity EIA assay at testing sites in Kiev city, Ukraine: 2013\u20132014. PLoS ONE, 11.","key":"ref_31","DOI":"10.1371\/journal.pone.0157179"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/13\/8\/795\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:27:56Z","timestamp":1760210876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/13\/8\/795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,6]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8]]}},"alternative-id":["ijerph13080795"],"URL":"https:\/\/doi.org\/10.3390\/ijerph13080795","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2016,8,6]]}}}