{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:24:51Z","timestamp":1789939491129,"version":"4.0.1"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>To evaluate the association among complement factor H-related (CFHRs) gene deficiency, complement factor H (CFH) autoantibodies, and atypical hemolytic uremic syndrome (aHUS) susceptibility. EMBASE, PubMed, and the ISI Web of Science databases were searched for all eligible studies on the relationship among CFHRs deficiency, anti-FH autoantibodies, and aHUS risk. Eight case-control studies with 927 cases and 1182 controls were included in this study. CFHR1 deficiency was significantly associated with an increased risk of aHUS (odds ratio (OR) = 3.61, 95% confidence interval (95% CI), 1.96, 6.63, p &lt; 0.001), while no association was demonstrated in individuals with only CFHR1\/R3 deficiency (OR = 1.32, 95% CI, 0.50, 3.50, p = 0.56). Moreover, a more significant correlation was observed in people with both FH-anti autoantibodies and CFHR1 deficiency (OR = 11.75, 95% CI, 4.53, 30.44, p &lt; 0.001) in contrast to those with only CFHR1 deficiency. In addition, the results were essentially consistent among subgroups stratified by study quality, ethnicity, and gene detection methods. The present meta-analysis indicated that CFHR1 deletion was significantly associated with the risk of aHUS, particularly when combined with anti-FH autoantibodies, indicating that potential interactions among CFHR1 deficiency and anti-FH autoantibodies might impact the risk of aHUS.<\/jats:p>","DOI":"10.3390\/ijerph13121209","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T10:27:09Z","timestamp":1480933629000},"page":"1209","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association among Complement Factor H Autoantibodies, Deletions of CFHR, and the Risk of Atypical Hemolytic Uremic Syndrome"],"prefix":"10.3390","volume":"13","author":[{"given":"Hong","family":"Jiang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, Xi\u2019an Jiaotong University College of Medicine, 277 Yanta West Road, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"},{"name":"School of Public Health, Xi\u2019an Jiaotong University Health Science Center, 76 Yanta West Road, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Nan","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Public Health, Xi\u2019an Jiaotong University Health Science Center, 76 Yanta West Road, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health, Xi\u2019an Jiaotong University Health Science Center, 76 Yanta West Road, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Lu","sequence":"additional","affiliation":[{"name":"Xi\u2019an Honghui Hospital, 555 Friendship Road, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi\u2019an Honghui Hospital, 555 Friendship Road, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Xi\u2019an Jiaotong University College of Medicine, 277 Yanta West Road, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-9779","authenticated-orcid":false,"given":"Le","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"},{"name":"School of Public Health, Xi\u2019an Jiaotong University Health Science Center, 76 Yanta West Road, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases (Xi\u2019an Jiaotong University), Ministry of Education of China, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJMra0902814","article-title":"Atypical hemolytic-uremic syndrome","volume":"361","author":"Noris","year":"2009","journal-title":"N. 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