{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:01:17Z","timestamp":1774468877078,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangzhou city science and technology plan-the Pearl River New Star special Project","award":["201506010072"],"award-info":[{"award-number":["201506010072"]}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473064"],"award-info":[{"award-number":["81473064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technique Major Project of China","award":["2012ZX10004912"],"award-info":[{"award-number":["2012ZX10004912"]}]},{"name":"National Science and Technique Major Project of China","award":["2012ZX10004213"],"award-info":[{"award-number":["2012ZX10004213"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>A hand-foot-mouth disease outbreak occurred in 2014 around Guangdong. The purpose of this study was investigating the status and susceptibility of infectious neutralizing antibodies to enterovirus 71 among children so as to provide scientific evidence for the population immunity level of hand-foot-mouth disease and prepare for enterovirus 71 vaccination implementation. Serum specimens were collected from children in communities from January 2014 to March 2015 in Guangzhou. A total of 197 serum samples from children 1\u20135 years old were collected for this cross-sectional study via non-probabilistic sampling from the database of Chinese National Science and Technique Major Project. Neutralization activity was measured via micro neutralization test in vitro. The positive rate of enterovirus 71 neutralizing antibodies was 59.4%, whereas the geometric mean titre was 1:12.7. A statistically significant difference in true positive rates was found between different age groups but not between different genders. Being the most susceptible population of hand\u2013foot\u2013mouth disease, children under 3 years of age are more likely to be infected with enterovirus 71, and the immunity of children increases with increasing age. Further cohort studies should be conducted, and measures for prevention and vaccination should be taken.<\/jats:p>","DOI":"10.3390\/ijerph14030319","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T11:39:09Z","timestamp":1490009949000},"page":"319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Enterovirus 71 Neutralizing Antibodies Seroepidemiological Research among Children in Guangzhou, China between 2014 and 2015: A Cross-Sectional Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Dingmei","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Public Health, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical College of Shaoguan University, No.1 Xinhuanan Road, Shaoguan 512000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiashi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenjian","family":"He","sequence":"additional","affiliation":[{"name":"School of Public Health, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuantao","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Public Health, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization Hand, Foot and Mouth Disease. 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