{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:58:49Z","timestamp":1790395129614,"version":"4.1.0"},"reference-count":167,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Although exposure to endocrine disruptor compounds (EDCs) has been suggested as a contributing factor to a range of women\u2019s health disorders including infertility, polycystic ovaries and the early onset of puberty, considerable challenges remain in attributing cause and effect on gynaecological cancer. Until recently, there were relatively few epidemiological studies examining the relationship between EDCs and endometrial cancer, however, in the last years the number of these studies has increased. Methods: A systematic MEDLINE (PubMed) search was performed and relevant articles published in the last 23 years (from 1992 to 2016) were selected. Results: Human studies and animal experiments are confirming a carcinogenic effect due to the EDC exposure and its carcinogenesis process result to be complex, multifactorial and long standing, thus, it is extremely difficult to obtain the epidemiological proof of a carcinogenic effect of EDCs for the high number of confusing factors. Conclusions: The carcinogenic effects of endocrine disruptors are plausible, although additional studies are needed to clarify their mechanisms and responsible entities. Neverthless, to reduce endocrine disruptors (ED) exposure is mandatory to implement necessary measures to limit exposure, particularly during those periods of life most vulnerable to the impact of oncogenic environmental causes, such as embryonic period and puberty.<\/jats:p>","DOI":"10.3390\/ijerph14030334","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T12:04:00Z","timestamp":1490184240000},"page":"334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies"],"prefix":"10.3390","volume":"14","author":[{"given":"Maddalena","family":"Mallozzi","sequence":"first","affiliation":[{"name":"Surgical and Medical Department of Translational Medicine, Sant\u2019Andrea Hospital, Faculty of Medicine and Psycology, University of Rome \u201cSapienza\u201d, Via di Grottarossa n\u00b0 1035, 00139 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Leone","sequence":"additional","affiliation":[{"name":"Surgical and Medical Department of Translational Medicine, Sant\u2019Andrea Hospital, Faculty of Medicine and Psycology, University of Rome \u201cSapienza\u201d, Via di Grottarossa n\u00b0 1035, 00139 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Manurita","sequence":"additional","affiliation":[{"name":"Surgical and Medical Department of Translational Medicine, Sant\u2019Andrea Hospital, Faculty of Medicine and Psycology, University of Rome \u201cSapienza\u201d, Via di Grottarossa n\u00b0 1035, 00139 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Bellati","sequence":"additional","affiliation":[{"name":"Surgical and Medical Department of Translational Medicine, Sant\u2019Andrea Hospital, Faculty of Medicine and Psycology, University of Rome \u201cSapienza\u201d, Via di Grottarossa n\u00b0 1035, 00139 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Caserta","sequence":"additional","affiliation":[{"name":"Surgical and Medical Department of Translational Medicine, Sant\u2019Andrea Hospital, Faculty of Medicine and Psycology, University of Rome \u201cSapienza\u201d, Via di Grottarossa n\u00b0 1035, 00139 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,3,22]]},"reference":[{"key":"ref_1","unstructured":"Damstra, T., Barlow, S., Bergman, A., Kavlock, R.J., and Van der Kraak, G. (2002). International Programme on Chemical Safety, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12426","DOI":"10.3390\/ijerph121012426","article-title":"Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features","volume":"12","author":"Tait","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00404-012-2643-5","article-title":"The influence of cigarette smoking on a population of infertile men and women","volume":"287","author":"Caserta","year":"2013","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_4","unstructured":"Cancer Incidence for Common Cancers. Available online: http:\/\/www.cancerresearchuk.org\/cancer-info\/cancerstats\/incidence\/commoncancers\/uk-cancer-incidence-statistics-for-common-cancers#Top3."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"A104","DOI":"10.1289\/ehp.1205448","article-title":"The impact of endocrine disruption: A consensus statement on the state of the science","volume":"121","author":"Bergman","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1071\/RD09300","article-title":"Negative impact of endocrine disrupting compounds on human reproductive health","volume":"23","author":"Balabanic","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_7","first-page":"633","article-title":"Flaws endocrine-disrupting chemicals in ovarian function: Effects on steroidogenesis","volume":"142","author":"Zelieann","year":"2011","journal-title":"Metab. Nuclear Recept. Signal."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1289\/ehp.5686","article-title":"Cancer and developmentalexposure to endocrine disruptors","volume":"111","author":"Birnbaum","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"T13","DOI":"10.1530\/ERC-13-0342","article-title":"Endocrinedisruption of oestrogen action and female reproductive tract cancers","volume":"21","author":"Gibson","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0079-6123(08)81012-6","article-title":"The multiple roles of estrogens and the enzyme aromatase","volume":"181","author":"Boon","year":"2010","journal-title":"Prog. Brain Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1210\/me.2007-0421","article-title":"Minireview: Nuclear receptors and breast cancer","volume":"22","author":"Conzen","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1200\/JCO.2009.27.4290","article-title":"Influence of sex hormones on cancer progression","volume":"28","author":"Folkerd","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"T33","DOI":"10.1530\/ERC-13-0513","article-title":"Endocrine disruption of the epigenome: A breast cancer link","volume":"21","author":"Knower","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1073\/pnas.86.10.3704","article-title":"Chlorambucil effectively induces deletion mutations in mouse germ cells","volume":"86","author":"Russel","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0165-7992(92)90089-Z","article-title":"Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids","volume":"282","author":"Russel","year":"1992","journal-title":"Mutat. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tig.2014.08.005","article-title":"On the meaning of the word \u201cepimutation\u201d","volume":"30","author":"Oey","year":"2014","journal-title":"Trends Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tem.2009.12.007","article-title":"Epigenetic transgenerational actions of environmental factors in disease etiology","volume":"21","author":"Skinner","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.mce.2015.01.035","article-title":"Responses miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets","volume":"418","author":"Klinge","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol A and human health: A review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12672-013-0150-1","article-title":"Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin","volume":"4","author":"Nordeen","year":"2013","journal-title":"Horm. Cancer"},{"key":"ref_21","first-page":"305","article-title":"Are cadmium and other heavy metal compounds acting as endocrinedisrupters?","volume":"8","author":"Kortenkamp","year":"2011","journal-title":"Met. Ions Life Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.taap.2009.01.006","article-title":"Gene expression profiling in Ishikawa cells: A fingerprint for estrogen active compounds","volume":"236","author":"Boehme","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/bit.21991","article-title":"Development of a stable dual cell-line GFP expression system to study estrogenic endocrine disruptors","volume":"101","author":"Xu","year":"2008","journal-title":"Biotechnol. Bioeng."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/humupd\/dmm025","article-title":"Impact of endocrine disruptor chemicals in gynaecology","volume":"14","author":"Caserta","year":"2008","journal-title":"Hum. Reprod. Update"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.envres.2005.05.004","article-title":"Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells","volume":"100","author":"Singleton","year":"2006","journal-title":"Environ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ygyno.2004.08.022","article-title":"Adipose tissue concentrations of p,p\u2019-DDE and the risk for endometrial cancer","volume":"95","author":"Hardell","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0378-4274(98)00331-2","article-title":"Ah receptor agonists as endocrine disruptors: Antiestrogenic activity and mechanisms","volume":"102\u2013103","author":"Safe","year":"1998","journal-title":"Toxicol. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1006\/bbrc.1998.9569","article-title":"Estrogenic and antiprogestagenic activities of pyrethroid insecticides","volume":"251","author":"Garey","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_29","first-page":"97","article-title":"A 29-year-old woman with complex atypical hyperplasia and polycystic ovary syndrome: A challenging issue","volume":"35","author":"Caserta","year":"2014","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.reprotox.2010.10.012","article-title":"Epigenetic transgenerational actions of endocrine disruptors","volume":"31","author":"Skinner","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1289\/ehp.97105s3675","article-title":"Is there an association between exposure to environmental estrogens and breast cancer?","volume":"105","author":"Safe","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"ref_33","first-page":"133","article-title":"Organochlorine exposure and risk for breast cancer","volume":"396","author":"Safe","year":"1997","journal-title":"Prog. Clin. Biol. Res."},{"key":"ref_34","first-page":"639","article-title":"Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs","volume":"107","author":"Brouwer","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/00001622-199809000-00018","article-title":"Environmental estrogens and breast cancer risk","volume":"10","author":"Davidson","year":"1998","journal-title":"Curr. Opin. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1289\/ehp.99107459","article-title":"Organochlorines in breast milk from two cities in Ukraine","volume":"107","author":"Gladen","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.2105\/AJPH.89.12.1832","article-title":"Outcomes of 17,137 pregnancies in 2 urban areas of Ukraine","volume":"89","author":"Little","year":"1999","journal-title":"Am. J. Public Health"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0887-2333(01)00045-5","article-title":"Endocrine disrupters\u2014Testing strategies to assess human hazard","volume":"15","author":"Baker","year":"2001","journal-title":"Toxicol. In Vitro"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/humupd\/7.3.323","article-title":"The impact of endocrine disrupters on the female reproductive system","volume":"7","author":"Pitsos","year":"2001","journal-title":"Hum. Reprod. Update"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/toxsci\/kfg149","article-title":"PCB 104-induced proinflammatory reactions in human vascular endothelial cells: Relationship to cancer metastasis and atherogenesis","volume":"75","author":"Choi","year":"2003","journal-title":"Toxicol. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.yexcr.2004.01.030","article-title":"VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells","volume":"296","author":"Eum","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1078\/1438-4639-00134","article-title":"PCB-induced oxidative stress in endothelial cells: Modulation by nutrients","volume":"205","author":"Hennig","year":"2002","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0303-7207(99)00041-6","article-title":"Estrogen and arylhydrocarbon responsiveness of ECC-1 endometrial cancer cells","volume":"150","author":"Wormke","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1590\/S0001-37652008000300011","article-title":"Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium","volume":"80","year":"2008","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tiv.2014.11.008","article-title":"The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells","volume":"29","author":"Chen","year":"2015","journal-title":"Toxicol. In Vitro"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.freeradbiomed.2009.09.024","article-title":"Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure","volume":"47","author":"Zhu","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1097-4644(19990101)72:1<94::AID-JCB10>3.0.CO;2-Y","article-title":"2,2\u2032,6,6\u2032-Tetrachlorobiphenyl is estrogenic in vitro and in vivo","volume":"72","author":"Arcaro","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/taap.1999.8710","article-title":"Developmental exposure of rats to a reconstituted PCB mixture or Aroclor 1254: Effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behavior","volume":"158","author":"Hany","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/jnci\/89.23.1774","article-title":"Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines","volume":"89","author":"Shekhar","year":"1997","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/taap.1998.8568","article-title":"Effects of the antiestrogenic environmental pollutant 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB #126) in rat bone and uterus: Diverging effects in ovariectomized and intact animals","volume":"154","author":"Lind","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/taap.1997.8281","article-title":"Additive estrogenic activities of a binary mixture of 2\u2032,4\u2032,6\u2032-trichloro- and 2\u2032,3\u2032,4\u2032,5\u2032-tetra-chloro-4-biphenylol","volume":"147","author":"Ramamoorthy","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/10408449509017924","article-title":"Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: An assessment of the biological and epidemiological evidence","volume":"25","author":"Ahlborg","year":"1995","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/BF00054165","article-title":"Organochlorine compounds and estrogen-related cancers in women","volume":"6","author":"Adami","year":"1995","journal-title":"Cancer Causes Control"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1023\/A:1008823802393","article-title":"Serum concentrations of organochlorine compounds and endometrial cancer risk (United States)","volume":"9","author":"Sturgeon","year":"1998","journal-title":"Cancer Causes Control"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1177\/0192623309351721","article-title":"Reproductive lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin and dioxin-like compounds","volume":"37","author":"Yoshizawa","year":"2009","journal-title":"Toxicol. Pathol."},{"key":"ref_56","first-page":"105","article-title":"High levels of xenoestrogens in patients with low-grade endometrial stromal sarcoma\u2014Report of two cases","volume":"31","author":"Reich","year":"2010","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_57","first-page":"487","article-title":"Organochlorines and endometrial cancer risk","volume":"9","author":"Weiderpass","year":"2000","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1477-7827-12-37","article-title":"Bisphenol A and the female reproductive tract: An overview of recent laboratory evidence and epidemiological studies","volume":"12","author":"Caserta","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.reprotox.2007.07.006","article-title":"Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract","volume":"24","author":"Newbold","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kwekel, J.C., Forgacs, A.L., Burgoon, L.D., Williams, K.J., and Zacharewski, T.R. (2009). Tamoxifen-elicited uterotrophy: Cross-species and cross-ligand analysis of the gene expression program. BMC Med. Genom., 2.","DOI":"10.1186\/1755-8794-2-19"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.reprotox.2015.10.011","article-title":"Bisphenol A-induced epithelial to mesenchymal transition is mediated by cyclooxygenase-2 up-regulation in human endometrial carcinoma cells","volume":"58","author":"Wang","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0303-7207(98)00202-0","article-title":"Estrogenicity of bisphenol A in a human endometrial carcinoma cell line","volume":"150","author":"Bergeron","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1101\/gr.135681.111","article-title":"Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner","volume":"22","author":"Gertz","year":"2012","journal-title":"Genome Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1002\/jnr.21739","article-title":"Signaling pathways of bisphenol A-induced apoptosis in hippocampal neuronal cells: Role of calcium-induced reactive oxygen species, mitogen-activated protein kinases, and nuclear factor-\u03baB","volume":"86","author":"Lee","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/toxsci\/kfi088","article-title":"Bisphenol A accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway","volume":"84","author":"Masuno","year":"2005","journal-title":"Toxicol. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1507\/endocrj.49.465","article-title":"The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type","volume":"49","author":"Kurosawa","year":"2002","journal-title":"Endocr. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1210\/endo.141.9.7649","article-title":"Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: Requirement of estrogen receptor-alpha","volume":"141","author":"Klotz","year":"2000","journal-title":"Endocrinology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jsbmb.2011.08.007","article-title":"Endocrine disrupting chemicals and disease susceptibility","volume":"27","author":"Schug","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1525-1373.2000.22401.x","article-title":"Activity of environmentally relevant low doses of endocrine disruptors and the bisphenol A controversy: Initial results confirmed","volume":"224","author":"Sheehan","year":"2000","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.3390\/ijerph110707537","article-title":"Bisphenol-A: Epigenetic reprogramming and effects on reproduction and behavior","volume":"11","author":"Mileva","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1289\/ehp.1205951","article-title":"Endocrine-disrupting chemicals (EDCs): In vitro mechanism of estrogenic activation and differential effects on ER target genes","volume":"121","author":"Li","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1289\/ehp.1104689","article-title":"Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor a and b in vitro","volume":"120","author":"Li","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1507\/endocrj.51.595","article-title":"Differences in serum bisphenol a concentrations in premenopausal normal women and women with endometrial hyperplasia","volume":"51","author":"Hiroi","year":"2004","journal-title":"Endocr. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2011.05.002","article-title":"Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects","volume":"127","author":"Rubin","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1289\/ehp.1104426","article-title":"Bisphenol A and its analogues activate human pregnane X receptor","volume":"120","author":"Sui","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/jat.3176","article-title":"Bisphenol A affects placental layers morphology and angiogenesis during early pregnancy phase in mice","volume":"35","author":"Tait","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbrc.2008.06.050","article-title":"ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner","volume":"373","author":"Matsushima","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ando.2013.04.002","article-title":"Bisphenol A: An endocrine and metabolic disruptor","volume":"74","author":"Fenichel","year":"2013","journal-title":"Ann. Endocrinol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jsbmb.2006.09.017","article-title":"Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: A potential novel mechanism of endocrine disruption","volume":"102","author":"Thomas","year":"2006","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.rbmo.2010.12.007","article-title":"Effect of bisphenol A on human endometrial stromal fibroblasts in vitro","volume":"22","author":"Aghajanova","year":"2011","journal-title":"Reprod. BioMed. Online"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.envint.2013.12.007","article-title":"Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives","volume":"64","author":"Rezg","year":"2014","journal-title":"Environ. Int."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/eci.12362","article-title":"Bisphenol A as epigenetic modulator: Setting the stage for carcinogenesis?","volume":"45","author":"Ferreira","year":"2015","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_83","first-page":"369","article-title":"Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure","volume":"41","author":"Fernandez","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1590\/S0102-311X2002000200010","article-title":"Dioxin exposure and porcine reproductive hormonal activity","volume":"18","author":"Gregoraszczuk","year":"2002","journal-title":"Cad. Saude Publica"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1556\/avet.2014.015","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin alters steroid secretion but does not affect cell viability and the incidence of apoptosis in porcine luteinised granulosa cells","volume":"62","author":"Jablonska","year":"2014","journal-title":"Acta Vet. Hung."},{"key":"ref_86","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR) (1998). Toxicological Profile for Chlorinated Dibenzo-p-Dioxins."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/aje\/153.11.1031","article-title":"Health effects on dioxin exposure: A 20-year mortality study","volume":"153","author":"Bertazzi","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2486\/indhealth.41.127","article-title":"Short- and long-term morbidity and mortality in the population exposed to dioxin after the \u201cSeveso accident\u201d","volume":"41","author":"Pesatori","year":"2003","journal-title":"Ind. Health"},{"key":"ref_89","unstructured":"Carcinogen Classificationon. Available online: http:\/\/www.iarc.fr\/ENG\/Databases\/index.php."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1530\/rep.1.00294","article-title":"Molecular interactions of the aryl hydrocarbon receptor and its biological and toxicological relevance for reproduction","volume":"129","author":"Pocar","year":"2005","journal-title":"Reproduction"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"17767","DOI":"10.1074\/jbc.M209594200","article-title":"Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor","volume":"278","author":"Bunger","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Moffat, I.D., Boutros, P.C., Chen, H., Okey, A.B., and Pohjanvirta, R. (2010). Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities. BMC Genom., 11.","DOI":"10.1186\/1471-2164-11-263"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0009-2797(02)00064-9","article-title":"The role of chaperone proteins in the aryl hydrocarbon receptor core complex","volume":"141","author":"Petrulis","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbrc.2004.06.177","article-title":"Dioxin-responsive AHRE-II gene battery: Identification by phylogenetic footprinting","volume":"321","author":"Boutros","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1126\/science.256.5060.1193","article-title":"Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor","volume":"256","author":"Reyes","year":"1992","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0041-008X(78)90075-3","article-title":"Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats","volume":"46","author":"Kociba","year":"1978","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0960-0760(90)90357-Q","article-title":"Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells","volume":"37","author":"Biegel","year":"1990","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0041-008X(88)90177-9","article-title":"Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus","volume":"92","author":"Romkes","year":"1988","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1021\/jf60198a039","article-title":"Retention and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin by rats","volume":"23","author":"Fries","year":"1975","journal-title":"J. Agric. Food Chem."},{"key":"ref_100","first-page":"6189","article-title":"Suppresion of estrogen-regulated extracellular tissue plasminogen activator activity of MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"47","author":"Gierthy","year":"1987","journal-title":"Cancer Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF01805943","article-title":"Inhibition of postconfluent focus production in cultures of MCF-7 human breast cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"12","author":"Gierthy","year":"1988","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1073\/pnas.87.17.6917","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells","volume":"87","author":"Spink","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1006\/abbi.1995.1411","article-title":"Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells","volume":"321","author":"Vogel","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0041-008X(87)90292-4","article-title":"Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats","volume":"87","author":"Romkes","year":"1987","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_105","first-page":"3579","article-title":"Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells","volume":"50","author":"Harris","year":"1990","journal-title":"Cancer Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0303-7207(93)90106-T","article-title":"Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells","volume":"96","author":"Wang","year":"1993","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"10533","DOI":"10.1074\/jbc.271.18.10533","article-title":"Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. Cross-talk between aryl hydrocarbon- and estrogen-mediated signaling","volume":"271","author":"Kharat","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1021\/bi962131b","article-title":"Identification of a motif within the 5\u2032 regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression","volume":"36","author":"Gillesby","year":"1997","journal-title":"Biochemistry"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00404-015-3739-5","article-title":"Correlation between dioxin and endometriosis: An epigenetic route to unravel the pathogenesis of the disease","volume":"292","author":"Sofo","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"S232","DOI":"10.1093\/carcin\/bgv038","article-title":"Environmental immune disruptors, inflammation and cancerrisk","volume":"36","author":"Thompson","year":"2015","journal-title":"Carcinogenesis"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1006\/bbrc.1997.7291","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin increases mRNA levels for interleukin-1beta, urokinase plasminogen activator, and tumor necrosis factor-alpha in human uterine endometrial adenocarcinoma RL95-2 cells","volume":"238","author":"Charles","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/abbi.1999.1288","article-title":"Role of estradiol receptor-alpha in differential expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible genes in the RL95\u20132 and KLE human endometrial cancer cell lines","volume":"368","author":"Jana","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_113","first-page":"1123","article-title":"Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review)","volume":"20","author":"Safe","year":"2002","journal-title":"Int. J. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/taap.1995.1187","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin induces diverse retinoic acid metabolites in multiple tissues of the Sprague-Dawley rat","volume":"134","author":"Fiorella","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00204-004-0550-7","article-title":"Role of the aryl hydrocarbon receptor and CYP1B1 in the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"78","author":"Takemoto","year":"2004","journal-title":"Arch. Toxicol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/MCB.23.6.1843-1855.2003","article-title":"The aryl hydrocarbon receptor mediates degradation of estrogen receptor a through activation of proteasomes","volume":"23","author":"Wormke","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1995.1080","article-title":"Subchronic dose-response study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats","volume":"132","author":"Fase","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3177\/jnsv.37.117","article-title":"Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the vitamin A status of Hartley guinea pigs, Sprague-Dawley rats, C57Bl\/6 mice, DBA\/2 mice, and Golden Syrian hamsters","volume":"37","author":"Hakansson","year":"1991","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1074\/jbc.274.6.3430","article-title":"Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells","volume":"274","author":"Ricci","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/00001648-199309000-00004","article-title":"Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin","volume":"4","author":"Bertazzi","year":"1993","journal-title":"Epidemiology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0041-008X(03)00277-1","article-title":"Alteration of keratinocyte differentiation and senescence by the tumor promoter dioxin","volume":"192","author":"Ray","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00204-003-0457-8","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the endogenous metabolism of all-trans-retinoic acid in the rat","volume":"77","author":"Schmidt","year":"2003","journal-title":"Arch. Toxicol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/62.1.166","article-title":"Hepatic vitamin a depletion is a sensitive marker of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in four rodent species","volume":"62","author":"Fletcher","year":"2001","journal-title":"Toxicol. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/0045-6535(94)90399-9","article-title":"Effect on tissue vitamin A levels in the rat following subchronic exposure to four individual PCB congeners (IUPAC 77, 118, 126, and 153)","volume":"29","author":"Hakansson","year":"1994","journal-title":"Chemosphere"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.yexcr.2005.04.026","article-title":"Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat","volume":"308","author":"Everts","year":"2005","journal-title":"Exp. Cell Res."},{"key":"ref_126","first-page":"6144","article-title":"Retinoid status and the control of keratin expression and adhesion during the histogenesis of squamous mataplasia of tracheal epithelium","volume":"52","author":"Lancillotti","year":"1992","journal-title":"Cancer Res."},{"key":"ref_127","first-page":"1987","article-title":"Suppression of squamous cell carcinoma growth and differentiation by retinoids","volume":"54","author":"Lotan","year":"1994","journal-title":"Cancer Res."},{"key":"ref_128","unstructured":"National Toxicology Program (2004). Toxicology and Carcinogenesis Studies of a Mixture of 3,30,4,40,5-pentachlorobiphenyl (PCB126) (CAS No. 57465-28-8) and 2,20,4,40,5,50-Hexachlorobiphenyl (PCB153) (CAS No. 57065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies), NIEHS. NTP TR530."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/toxsci\/kfi016","article-title":"Gingival carcinogenicity in female Harlan Sprague-Dawley rats following two-year oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds","volume":"83","author":"Yoshizawa","year":"2005","journal-title":"Toxicol. Sci."},{"key":"ref_130","first-page":"1964","article-title":"Environment and Endometriosis: A toxic relationship","volume":"19","author":"Soave","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/IGC.0000000000000454","article-title":"The risks for ovarian, endometrial, breast, colorectal, and other cancers in women with newly diagnosed endometriosis or adenomyosis: A population-based study","volume":"25","author":"Kok","year":"2015","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.anndiagpath.2006.08.011","article-title":"Adenomyosis involved by endometrial adenocarcinoma is a significant risk factor for deep myometrial invasion","volume":"11","author":"Ismiil","year":"2007","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/01.pgp.0000235064.93182.ec","article-title":"Adenomyosis is associated with myometrial invasion by FIGO 1 endometrial adenocarcinoma","volume":"26","author":"Ismiil","year":"2007","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0090-8258(84)90057-X","article-title":"The prognostic significance of adenomyosis in endometrial carcinoma","volume":"17","author":"Hall","year":"1984","journal-title":"Gynecol. Oncol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cdp.2003.12.008","article-title":"The relationship between endometrial carcinoma and coexistent adenomyosis uteri, endometriosis externa and myoma uteri","volume":"28","author":"Koshiyama","year":"2004","journal-title":"Cancer Detect. Prev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1055\/s-0035-1558239","article-title":"Endometriosis-associated Malignancy","volume":"76","author":"Krawczyk","year":"2016","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"ref_137","unstructured":"Agency for Toxic Substances and Disease Registry (2011). Toxicological Profile for Cadmium."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","article-title":"Current status of cadmium as an environmental health problem","volume":"238","author":"Jarup","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.3390\/ijerph6071930","article-title":"Tobacco smoke exposure and levels of urinary metals in the U.S. youth and adult population: The National Health and Nutrition Examination Survey (NANHES) 1991\u20132004","volume":"6","author":"Richter","year":"2009","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1078\/1438-4639-00260","article-title":"Revised and new reference values for some trace elements in blood and urine for human biomonitoring in environmental medicine","volume":"207","author":"Wilhelm","year":"2004","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/enrs.2002.4338","article-title":"Metals and women\u2019s health","volume":"88","author":"Vahter","year":"2002","journal-title":"Environ. Res. Sec. A"},{"key":"ref_142","unstructured":"Friberg, L., Elinder, C.G., Kjellstrom, T., and Nordberg, G.F. (1986). Cadmium and Health: A Toxicological and Epidemiological Appraisal, CRC Press."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1191\/0960327105ht575oa","article-title":"Tissue levels of cadmium and trace elements in patients with myoma and uterine cancer","volume":"24","author":"Nasiadek","year":"2005","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_144","first-page":"1","article-title":"Health effects of cadmium exposure\u2014A review of the literature and a risk estimate","volume":"24","author":"Jarup","year":"1998","journal-title":"Scan. J. Work Environ. Health"},{"key":"ref_145","first-page":"545","article-title":"Activation of estrogen receptor-\u03b1 by the heavy metal cadmium","volume":"14","author":"Stoica","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.1158\/0008-5472.CAN-08-0329","article-title":"Long-term dietary cadmium intake and postmenopausal endometrial cancer incidence: A population-based prospective cohort study","volume":"68","author":"Akesson","year":"2008","journal-title":"Cancer Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1470-2045(06)70545-9","article-title":"Environmental exposure to cadmium and risk of cancer: A prospective population-based study","volume":"7","author":"Nawrot","year":"2006","journal-title":"Lancet Oncol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.toxlet.2010.01.015","article-title":"Cadmium-induced inflammatory responses in cells relevant for lung toxicity: Expression and release of cytokines in fibroblasts, epithelial cells and macrophages","volume":"193","author":"Lag","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.taap.2009.01.029","article-title":"Role of oxidative stress in cadmium toxicity and carcinogenesis","volume":"238","author":"Liu","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0378-4274(99)00273-8","article-title":"Interference by toxic metal compounds with isolated zinc finger DNA repair proteins","volume":"112\u2013113","author":"Asmuss","year":"2000","journal-title":"Toxicol. Lett."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.taap.2006.03.008","article-title":"DNA repair systems as targets of cadmium toxicity","volume":"213","author":"Giaginis","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0014-4827(03)00062-4","article-title":"Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation","volume":"286","author":"Takiguchi","year":"2003","journal-title":"Exp. Cell Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.taap.2007.12.017","article-title":"Rapid activation of ERK1\/2 and AKT in human breast cancer cells by cadmium","volume":"228","author":"Liu","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"16896","DOI":"10.1016\/S0021-9258(19)89474-7","article-title":"Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells","volume":"269","author":"Saceda","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nm902","article-title":"Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland","volume":"9","author":"Johnson","year":"2003","journal-title":"Nat. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1289\/ehp.0900999","article-title":"Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype","volume":"117","author":"Tokar","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Eriksen, K.T., Halkj\u00e6r, J., S\u00f8rensen, M., Meliker, J.R., McElroy, J.A., Tj\u00f8nneland, A., and Raaschou-Nielsen, O. (2014). Dietary cadmium intake and risk of breast, endometrial and ovarian cancer in Danish postmenopausal women: A prospective cohort study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100815"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1289\/ehp.1307054","article-title":"Dietary cadmium exposure and risk of breast, endometrial, and ovarian cancer in the Women\u2019s Health Initiative","volume":"122","author":"Adams","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Cho, Y.A., Kim, J., Woo, H.D., and Kang, M. (2013). Dietary cadmium intake and the risk of cancer: A meta-analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075087"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1525-1438.2006.00742.x","article-title":"Comparison of trace element concentrations in cancerous and noncancerous human endometrial and ovary tissues","volume":"17","author":"Yaman","year":"2007","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/EDE.0b013e31824d063c","article-title":"Long-term dietary cadmium intake and cancer incidence","volume":"23","author":"Sawada","year":"2012","journal-title":"Epidemiology"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/bjc.2011.238","article-title":"Dietary cadmium exposure and risk of epithelial ovarian cancer in a prospective cohort of Swedish women","volume":"105","author":"Julin","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s10552-012-9953-6","article-title":"Dietary cadmium and risk of invasive postmenopausal breast cancer in the VITAL cohort","volume":"23","author":"Adams","year":"2012","journal-title":"Cancer Causes Control"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/bjc.2012.311","article-title":"Dietary cadmium exposure and prostate cancer incidence: A population-based prospective cohort study","volume":"107","author":"Julin","year":"2012","journal-title":"Br. J. Cancer"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1158\/0008-5472.CAN-11-0735","article-title":"Dietary cadmium exposure and risk of postmenopausal breast cancer: A population-based prospective cohort study","volume":"72","author":"Julin","year":"2012","journal-title":"Cancer Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"S588","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mce.2014.07.019","article-title":"Endocrine disruptor induction of epigenetic transgenerational inheritance of disease","volume":"398","author":"Skinner","year":"2014","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/14\/3\/334\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:31:01Z","timestamp":1760207461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/14\/3\/334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,22]]},"references-count":167,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3]]}},"alternative-id":["ijerph14030334"],"URL":"https:\/\/doi.org\/10.3390\/ijerph14030334","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,22]]}}}