{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:14:43Z","timestamp":1760242483985,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Cancer is a serious public health issue and the leading cause of death around the world. This article aimed to estimate the cancer incidence and the trend in standardized cancer incidence in Shenzhen, Guangdong province, South China during 2001\u20132015 by analyzing the cancer data of the population-based cancer registry in Shenzhen. Data were collected from the cancer registry in Shenzhen, which was conducted during 2001\u20132015. In this registry, the crude incidence rates, age-specific incidence rates, age-standardized incidence rates and cumulative incidence rates were calculated in every five years. Trends for standardized incidence rates of cancers were analyzed by using the joinpoint regression analysis. In total, 33,374.3 thousand person-years (17,593.9 thousand for males and 15,780.4 thousand for females) were monitored over this time period. The number of new cancer cases during 2001\u20132015 was 59,218 (30,144 and 29,074 for males and females, respectively). The crude incidence during 2001\u20132005 was 136.44 per 100,000 persons, while the age-standardized rates by Chinese standard population (ASR-China) and by world standard population (ASR-world) were 165.13 and 212.48 per 100,000 persons, respectively. The crude incidence during 2006\u20132010 was 179.01 per 100,000 persons, while the ASR-China and ASR-world were 168.08 and 214.44 per 100,000 persons, respectively. The crude incidence during 2011\u20132015 was 196.53 per 100,000 persons, while the ASR-China and ASR-world were 171.44 and 219.99 per 100,000 persons, respectively. During 2001 and 2015, the joinpoint regression analysis showed that the ASR-China of cancer had an overall increase of 0.96% per year and 0.84% per year for males and females respectively, although both of these values (males and females) were non-significant increases. The leading cancer types during 2011\u20132015 were lung, colorectal, thyroid gland, breast, liver, stomach, cervix, nasopharynx, leukemia and lymphoma. For males, the top five common cancers were lung, liver, colorectal, stomach and thyroid gland. For females, the top five common cancers were breast, thyroid gland, lung, colorectal and cervix. The results of this study showed a heavy cancer burden among the population of Shenzhen, China. Future researches of the etiology and prevention of cancers should be planned in order to reduce the incidence associated with cancers in the future.<\/jats:p>","DOI":"10.3390\/ijerph14101137","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T10:52:25Z","timestamp":1506509545000},"page":"1137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Incidence of Cancer in Shenzhen, Guangdong Province during 2001\u20132015: A Retrospective Population-Based Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Zhongyu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lei","sequence":"additional","affiliation":[{"name":"Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiye","family":"Yu","sequence":"additional","affiliation":[{"name":"Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanjin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Peng","sequence":"additional","affiliation":[{"name":"Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-3772","authenticated-orcid":false,"given":"Ping","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"Cancer. J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"Cancer. J. Clin."},{"key":"ref_3","first-page":"61","article-title":"Report of cancer incidence and mortality in China, 2010","volume":"2","author":"Chen","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/01635581.2015.1019634","article-title":"Dairy consumption and gastric cancer risk: A meta-analysis of epidemiological studies","volume":"67","author":"Guo","year":"2015","journal-title":"Nutr. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4103\/2278-330X.149957","article-title":"Epidemiological research on cancers by cancer registries: A view point","volume":"4","author":"Krishnatreya","year":"2015","journal-title":"South. Asian. J. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.21147\/j.issn.1000-9604.2016.03.05","article-title":"Cancer incidence and mortality in Guangdong province, 2012","volume":"28","author":"Meng","year":"2016","journal-title":"Chin. J. Cancer. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"636","DOI":"10.4103\/0366-6999.177969","article-title":"Cancer incidence and mortality survey in Wuwei, Gansu Province, Northwestern China from 2003 to 2012: A retrospective population-based study","volume":"129","author":"Li","year":"2016","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref_8","first-page":"13","article-title":"Population-based cancer incidence analysis in Beijing, 2008\u20132012","volume":"27","author":"Yang","year":"2015","journal-title":"Chin. J. Cancer. Res."},{"key":"ref_9","first-page":"105","article-title":"Some uses of the cancer registry in cancer control","volume":"16","author":"Pedersen","year":"1962","journal-title":"Br. J. Prev. Soc. Med."},{"key":"ref_10","first-page":"427","article-title":"Evaluation on Cancer Registry in Shenzhen, Guangdong Province","volume":"19","author":"Zhou","year":"2010","journal-title":"China Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ejca.2008.11.032","article-title":"Evaluation of data quality in the cancer registry: Principles and methods. Part I: Comparability, validity and timeliness","volume":"45","author":"Bray","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.ejca.2008.11.032","article-title":"Evaluation of data quality in the cancer registry: principles and methods. Part II: completeness","volume":"45","author":"Bray","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1742-7622-4-3","article-title":"Age standardization\u2014An indigenous standard?","volume":"4","author":"Robson","year":"2007","journal-title":"Emerg. Themes Epidemiol."},{"key":"ref_14","unstructured":"Ahmad, O., Boschi-Pinto, C., Lopez, A., Murray, C., Lozano, R., and Inoue, M. (2000). Age Standardization of Rates: A New WHO Standard, World Health Organization."},{"key":"ref_15","unstructured":"Segi, M., and Kurihara, M. (1972). Cancer Mortality for Selected Sites in 24 Countries No. 6 (1966\u20131967), Japan Cancer Society."},{"key":"ref_16","first-page":"161","article-title":"An Analysis of Cancer Incidence in China, 2003~2007","volume":"21","author":"Chen","year":"2012","journal-title":"China Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z","article-title":"Permutation tests for joinpoint regression with applications to cancer rates","volume":"19","author":"Kim","year":"2000","journal-title":"Stat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3346\/jkms.2010.25.8.1113","article-title":"Cancer Statistics in Korea: Incidence, Mortality and Survival in 2006\u20132007","volume":"25","author":"Jung","year":"2010","journal-title":"J. Korean. Med. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40880-015-0042-6","article-title":"The updated incidences and mortalities of major cancers in China, 2011","volume":"34","author":"Chen","year":"2015","journal-title":"Chin. J. Cancer"},{"key":"ref_20","unstructured":"Tao, Y., and Lu, Z. (2008). China\u2019s Economic Zones: Design, Implementation, and Impact, Social Sciences Academic Press."},{"key":"ref_21","unstructured":"(2015, October 10). Scientific Report of the 2015 Dietary Guidelines Advisory, Available online: http:\/\/health.gov\/dietaryguidelines\/2015-scientific-report\/PDFs\/07-Part-D-Chapter-2.pdf."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/toxsci\/kft132","article-title":"Global risk assessment of Aflatoxins in maize and peanuts: Are regulatory standards adequately protective?","volume":"135","author":"Wu","year":"2013","journal-title":"Toxicol. Sci."},{"key":"ref_23","first-page":"610","article-title":"Survey of aflatoxins contamination of foodstuffs and edible oil in Shenzhen","volume":"42","author":"Li","year":"2013","journal-title":"J. Hyg. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1053\/j.gastro.2011.12.061","article-title":"Epidemiology of viral hepatitis and hepatocellular carcinoma","volume":"142","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_25","first-page":"80","article-title":"Epidemiological survey and prevention and control measures of hepatitis B from 2013 to 2015 in Shenzhen area","volume":"33","author":"Zeng","year":"2017","journal-title":"J. Baotou Med. Coll."},{"key":"ref_26","first-page":"876","article-title":"Characteristics of hepatitis C and HIV\/AIDS infection in Shenzhen city from 2010 to 2012","volume":"14","author":"Kong","year":"2014","journal-title":"China Trop. Med."},{"key":"ref_27","first-page":"1543","article-title":"Investigation of health status and lifestyles of the residents in Nanshan district, Shenzhen","volume":"13","author":"Chen","year":"2013","journal-title":"J. Trop. Med."},{"key":"ref_28","unstructured":"IARC working group (2002). Weight control and physical activity. IARC Handbooks of Cancer Prevention, IARC. [6th ed.]."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0140-6736(08)60269-X","article-title":"Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies","volume":"371","author":"Renehan","year":"2008","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ijc.23033","article-title":"Tobacco smoking and cancer: a meta-analysis","volume":"122","author":"Gandini","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1470-2045(06)70577-0","article-title":"Alcohol and cancer","volume":"7","author":"Boffetta","year":"2006","journal-title":"Lancet Oncol."},{"key":"ref_32","unstructured":"Outdoor Air Pollution (2017, March 06). Lyon (FR): International Agency for Research on Cancer. Available online: http:\/\/publications.iarc.fr\/Book-And-Report-Series\/Iarc-Monographs-On-The-Evaluation-Of-Carcinogenic-Risks-To-Humans\/Outdoor-Air-Pollution-2015."},{"key":"ref_33","first-page":"512","article-title":"Air pollutants change in Shenzhen, China in 2002\u20132005","volume":"23","author":"Yu","year":"2006","journal-title":"J. Environ. Health"},{"key":"ref_34","unstructured":"World Health Organization (2007). Cervical Cancer, Human Papillomavirus (HPV), and HPV Vaccines \u2013Key Points for Policy-Makers and Health Professionals, WHO Press."},{"key":"ref_35","unstructured":"Xi, K. (2008). Study on Health Education and Health Promotion Policy in Shenzhen. [Master\u2019s Thesis, Fudan University]."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s10552-010-9580-z","article-title":"Pickled meat consumption and colorectalcancer (CRC): A case-control study in Newfoundland and Labrador, Canada","volume":"21","author":"Squires","year":"2010","journal-title":"Cancer Causes Control"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/sj.bjc.6605372","article-title":"Pickled vegetables and the risk of oesophageal cancer: A meta-analysis","volume":"101","author":"Islami","year":"2009","journal-title":"Br. J. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Xie, S., Chen, J., Zhang, B., Wang, F., Li, S., Xie, C., Tse, L., and Cheng, J. (2014). Time trends and age-period-cohort analyses on incidence rates of thyroid cancer in Shanghai and Hong Kong. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-975"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"T235","DOI":"10.1530\/ERC-14-0131","article-title":"The influence of the environment on the development of thyroid tumors: A new appraisal","volume":"21","author":"Marcello","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4103\/1008-682X.132780","article-title":"Prostate cancer in East Asia: Evolving trend over the last decade","volume":"17","author":"Zhu","year":"2015","journal-title":"Asian J. Androl."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/ijc.26042","article-title":"The burden of cervical cancer in China: Synthesis of the evidence","volume":"130","author":"Shi","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_42","first-page":"971","article-title":"Exploration of cervical cancer preventive experiences in city\u201410 years of cervical cancer prevention in Shenzhen","volume":"24","author":"Li","year":"2015","journal-title":"China Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1634\/theoncologist.2013-0123","article-title":"Changes in prevalence and clinical characteristics of cervical cancer in the People\u2019s Republic of China: A study of 10,012 Cases From a Nationwide Working Group","volume":"18","author":"Li","year":"2013","journal-title":"Oncologist"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/14\/10\/1137\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:46:06Z","timestamp":1760208366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/14\/10\/1137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10]]}},"alternative-id":["ijerph14101137"],"URL":"https:\/\/doi.org\/10.3390\/ijerph14101137","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2017,9,27]]}}}