{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:10:17Z","timestamp":1760195417419,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CDRPG8D0043"],"award-info":[{"award-number":["CDRPG8D0043"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The Osteoporosis Self-assessment Tool for Asians (OSTA) is a validated index based on age and weight to predict the risk of osteoporosis in women. This cross-sectional study was designed to evaluate the impact of sexual dimorphism on the trauma patterns and the clinical outcomes of patients with high-risk OSTA scores. Trauma data of patients with high-risk OSTA scores between 1 January 2009 and 31 December 2015 were retrieved from the trauma registry system of a level I trauma center. A total of 2248 patients including 1585 women and 663 men were included in this study. In-hospital mortality was assessed as the primary outcome in the propensity score-matched analyses of the female and male patients, which were created in a 1:1 ratio under the adjustment of potential confounders, including age, co-morbidity, mechanism and injury-severity score (ISS). Female patients with a high-risk OSTA score had significantly lower mortality rates than their male counterparts. Among the propensity score-matched population, female patients had lower odds of having cerebral contusion and pneumothorax, but higher odds of presenting with radial, ulnar and femoral fractures than male patients. In addition, the female patients still had significantly lower odds of mortality (odds ratio (OR), 0.5; 95% confidence interval (CI), 0.29\u20130.90; p = 0.019) than the male patients. However, no significant differences were noted in the length of stay (LOS) in hospital, intensive-care unit (ICU) admission, and LOS in the ICU between the sexes. Female patients with high-risk OSTA scores showed different injury patterns and significantly lower mortality rates than their male counterparts, even after controlling for potential confounding factors.<\/jats:p>","DOI":"10.3390\/ijerph15030418","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T14:18:08Z","timestamp":1519741088000},"page":"418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Sexual Dimorphism on Trauma Patterns and Clinical Outcomes of Patients with a High-Risk Score of the Osteoporosis Self-Assessment Tool for Asians: A Propensity Score-Matched Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-0736","authenticated-orcid":false,"given":"Chien-En","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang-Tsung","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pao-Jen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiun-Yuan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Che","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0945-2746","authenticated-orcid":false,"given":"Ching-Hua","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/01.blo.0000200248.34876.fe","article-title":"Burden of osteoporosis","volume":"443","author":"Atik","year":"2006","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s001980170070","article-title":"A simple tool to identify Asian women at increased risk of osteoporosis","volume":"12","author":"LK","year":"2001","journal-title":"Osteoporos. Int."},{"key":"ref_4","first-page":"461","article-title":"Validation of three tools for identifying painful new osteoporotic vertebral fractures in older Chinese men: Bone mineral density, Osteoporosis Self-Assessment Tool for Asians, and fracture risk assessment tool","volume":"11","author":"Lin","year":"2016","journal-title":"Clin. Interven. Aging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1007\/s00198-005-0051-4","article-title":"Validation of various osteoporosis risk indices in elderly Chinese females in Singapore","volume":"17","author":"Chan","year":"2006","journal-title":"Osteoporos. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1007\/s00198-005-1929-x","article-title":"Validation of OSTA among Filipinos","volume":"16","author":"Llamado","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00774-013-0426-0","article-title":"Development and validation of osteoporosis risk-assessment model for Korean postmenopausal women","volume":"31","author":"Oh","year":"2013","journal-title":"J. Bone Miner. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3349\/ymj.2016.57.1.187","article-title":"Development and Validation of Osteoporosis Risk-Assessment Model for Korean Men","volume":"57","author":"Oh","year":"2016","journal-title":"Yonsei Med. J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Su, F.M., Liu, D.H., Chen, J.F., Yu, S.F., Chiu, W.C., Hsu, C.Y., Ko, C.H., Tsai, C.C., and Cheng, T.T. (2015). Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women\u2014A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS). PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0130716"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yang, Y., Wang, B., Fei, Q., Meng, Q., Li, D., Tang, H., Li, J., and Su, N. (2013). Validation of an osteoporosis self-assessment tool to identify primary osteoporosis and new osteoporotic vertebral fractures in postmenopausal Chinese women in Beijing. BMC Musculoskelet. Disord., 14.","DOI":"10.1186\/1471-2474-14-271"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1515\/med-2016-0036","article-title":"Clinical value of self-assessment risk of osteoporosis in Chinese","volume":"11","author":"Zhang","year":"2016","journal-title":"Open Med. (Wars)"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bj.2016.10.005","article-title":"Differences between the sexes in motorcycle-related injuries and fatalities at a Taiwanese level I trauma center","volume":"40","author":"Hsieh","year":"2017","journal-title":"Biomed. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1007\/s11999-011-1780-7","article-title":"Gender differences in osteoporosis and fractures","volume":"469","author":"Cawthon","year":"2011","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.aap.2009.11.008","article-title":"Killer crashes: Fatal road traffic accidents in the UK","volume":"42","author":"Clarke","year":"2010","journal-title":"Accid. Anal. Prevent."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/ip.2008.019679","article-title":"Substance use among road traffic casualties admitted to emergency departments","volume":"15","author":"Perez","year":"2009","journal-title":"J. Int. Soc. Child Adolesc. Inj. Prev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/JTN.0b013e3182562955","article-title":"Understanding trauma as a men\u2019s health issue: Sex differences in traumatic injury presentations at a level 1 trauma center in Australia","volume":"19","author":"Mitchell","year":"2012","journal-title":"J. Trauma Nurs."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1072-7515(02)01187-0","article-title":"A statewide population-based study of gender differences in trauma: Validation of a prior single-institution study","volume":"195","author":"Gannon","year":"2002","journal-title":"J. Am. Coll. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3390\/ijerph13121203","article-title":"Association between the Osteoporosis Self-Assessment Tool for Asians Score and Mortality in Patients with Isolated Moderate and Severe Traumatic Brain Injury: A Propensity Score-Matched Analysis","volume":"13","author":"Rau","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3390\/ijerph13100995","article-title":"Association of Osteoporosis Self-Assessment Tool for Asians (OSTA) Score with Clinical Presentation and Expenditure in Hospitalized Trauma Patients with Femoral Fractures","volume":"13","author":"Chen","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1749-799X-1-14","article-title":"Concordane of OSTA and lumbar spine BMD by DXA in identifying risk of osteoporosis","volume":"1","author":"Lu","year":"2006","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5704\/MOJ.1203.011","article-title":"Performance of Osteoporosis Self-assessment Tool for Asian (OSTA) for Primary Osteoporosis in Post-menopausal Malay Women","volume":"6","author":"Muslim","year":"2012","journal-title":"Malays. Orthop. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jocd.2016.04.005","article-title":"Utility of Osteoporosis Self-Assessment Tool as a Screening Tool for Predicting Osteoporosis in Indian Men","volume":"20","author":"Bhat","year":"2017","journal-title":"J. Clin. Densitom."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3390\/ijerph14111380","article-title":"Epidemiology of Bone Fracture in Female Trauma Patients Based on Risks of Osteoporosis Assessed using the Osteoporosis Self-Assessment Tool for Asians Score","volume":"14","author":"Rau","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bj.2016.10.006","article-title":"Motorcycle-related hospitalizations of the elderly","volume":"40","author":"Hsieh","year":"2017","journal-title":"Biomed. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0140-6736(74)91639-0","article-title":"Assessment of coma and impaired consciousness. A practical scale","volume":"2","author":"Teasdale","year":"1974","journal-title":"Lancet"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"(1971). Rating the severity of tissue damage. I. The abbreviated scale. JAMA, 215, 277\u2013280.","DOI":"10.1001\/jama.215.2.277"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005373-197403000-00001","article-title":"The injury severity score: A method for describing patients with multiple injuries and evaluating emergency care","volume":"14","author":"Baker","year":"1974","journal-title":"J. Trauma"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/TA.0b013e318250cced","article-title":"Injury pattern, injury severity, and mortality in 33,495 hospital-admitted victims of motorized two-wheeled vehicle crashes in The Netherlands","volume":"72","author":"Leijdesdorff","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1177\/000313480006600912","article-title":"Blunt chest trauma in the elderly patient: how cardiopulmonary disease affects outcome","volume":"66","author":"Alexander","year":"2000","journal-title":"Am. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3390\/ijerph14121552","article-title":"Same Abbreviated Injury Scale Values May Be Associated with Different Risks to Mortality in Trauma Patients: A Cross-Sectional Retrospective Study Based on the Trauma Registry System in a Level I Trauma Center","volume":"14","author":"Rau","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_31","first-page":"29","article-title":"The influence of sex steroid hormones on the response to trauma and burn injury","volume":"5","author":"Moiemen","year":"2017","journal-title":"Burns. Trauma"},{"key":"ref_32","first-page":"91","article-title":"Gender-Specific Effects on Immune Response and Cardiac Function after Trauma Hemorrhage and Sepsis","volume":"30","author":"Albertsmeier","year":"2014","journal-title":"Viszeralmedizin"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/archsurg.135.4.425","article-title":"Do female sex steroids adversely or beneficially affect the depressed immune responses in males after trauma-hemorrhage?","volume":"135","author":"Knoferl","year":"2000","journal-title":"Arch. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jsbmb.2013.10.009","article-title":"The Women\u2019s Health Initiative trial and related studies: 10 years later: A clinician\u2019s view","volume":"142","author":"Gurney","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2147\/VHRM.S9252","article-title":"Feasibility and effectiveness of a disease and care management model in the primary health care system for patients with heart failure and diabetes (Project Leonardo)","volume":"6","author":"Ciccone","year":"2010","journal-title":"Vasc. Health Risk Manag."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/3\/418\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:56:47Z","timestamp":1760194607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/3\/418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,27]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["ijerph15030418"],"URL":"https:\/\/doi.org\/10.3390\/ijerph15030418","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2018,2,27]]}}}