{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:20:23Z","timestamp":1790666423924,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The environmental determinants of pediatric embryonal tumors remain unclear. Because of the growing concern over the impact of exposures to traffic-related air pollution on pediatric cancer, we conducted a population-based study evaluating the impact of maternal residential proximity to major roadways on the risk of pediatric embryonal tumors in offspring. We identified children diagnosed with neuroblastoma, Wilms tumor, retinoblastoma, or hepatoblastoma at &lt;5 years of age from the Texas Cancer Registry and selected unaffected controls from birth certificates. Two residential proximity measures were used: (1) distance to the nearest major roadway, and (2) within 500 m of a major roadway. Logistic regression was used to estimate the adjusted odds ratio (aOR) and 95% confidence interval (CI) for each proximity measure on pediatric embryonal tumors. The odds of an embryonal tumor were increased in children born to mothers living within 500 m of a major roadway (aOR = 1.24, 95% CI: 1.00, 1.54). This was consistent for most tumor subtypes, with the strongest associations observed for unilateral retinoblastoma (aOR = 2.57, 95% CI: 1.28, 5.15, for every kilometer closer the mother lived to the nearest major roadway). These findings contribute to the growing evidence that traffic-related air pollution may increase risk for certain pediatric tumors.<\/jats:p>","DOI":"10.3390\/ijerph15030505","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T13:37:21Z","timestamp":1520948241000},"page":"505","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring"],"prefix":"10.3390","volume":"15","author":[{"given":"Shwetha","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, 1200 Pressler Street, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Lupo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Pompeii","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, 1200 Pressler Street, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Danysh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.ejca.2011.12.027","article-title":"Embryonal cancers in Europe","volume":"48","author":"Gatta","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e623","DOI":"10.1542\/peds.2015-0224","article-title":"Incidence, Trends, and Survival of Children With Embryonal Tumors","volume":"136","author":"Tulla","year":"2015","journal-title":"Pediatrics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1158\/1055-9965.EPI-14-1418","article-title":"Survivors of childhood cancer in the United States: Prevalence and burden of morbidity","volume":"24","author":"Phillips","year":"2015","journal-title":"Cancer Epidemiol. Prev. Biomark."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-3016.2010.01133.x","article-title":"Wilms\u2019 tumour: A systematic review of risk factors and meta-analysis","volume":"24","author":"Chu","year":"2010","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/978-1-4419-6448-9_21","article-title":"Retinoblastoma","volume":"685","author":"Lohmann","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10552-008-9243-5","article-title":"Perinatal risk factors for neuroblastoma","volume":"20","author":"McLaughlin","year":"2009","journal-title":"Cancer Causes Control"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/sj.bjc.6604335","article-title":"Perinatal risk factors for hepatoblastoma","volume":"98","author":"Spector","year":"2008","journal-title":"Br. J. Cancer"},{"key":"ref_8","first-page":"573","article-title":"Critical windows of exposure for children\u2019s health: Cancer in human epidemiological studies and neoplasms in experimental animal models","volume":"108","author":"Anderson","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"ref_9","unstructured":"Health Effects Institute (2010). Traffic-Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure and Health Effects, Health Effects Institute. 2010 Special Report #17."},{"key":"ref_10","unstructured":"International Agency for Research on Cancer (1989). Diesel and gasoline engine exhausts and some nitroarenes. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, International Agency for Research on Cancer."},{"key":"ref_11","unstructured":"Population Reference Bureau (2018, January 21). 2017 World Population Data Sheet. Available online: http:\/\/www.prb.org\/pdf17\/2017_World_Population.pdf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.envres.2016.01.012","article-title":"Maternal residential proximity to major roadways at delivery and childhood central nervous system tumors","volume":"146","author":"Danysh","year":"2016","journal-title":"Environ. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s10654-015-0091-9","article-title":"Childhood cancer and residential exposure to highways: A nationwide cohort study","volume":"30","author":"Spycher","year":"2015","journal-title":"Eur. J. Epidemiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/cncr.20910","article-title":"International Classification of Childhood Cancer, third edition","volume":"103","author":"Stiller","year":"2005","journal-title":"Cancer"},{"key":"ref_15","unstructured":"Texas Department of State Health Services (2018, January 21). Texas Cancer Registry: Data Linkages, Available online: https:\/\/www.dshs.texas.gov\/tcr\/data\/linkages.aspx."},{"key":"ref_16","unstructured":"Texas Natural Resources Information System (2014, December 01). Maps & Data: Transportation StratMap, Version 2 (2006). Available online: http:\/\/tnris.org\/data-download\/#\/statewide."},{"key":"ref_17","unstructured":"U.S. Census Bureau (2007). TIGER\/Line Files: Technical Documentation."},{"key":"ref_18","first-page":"5730","article-title":"Pre- and postconception factors associated with sporadic heritable and nonheritable retinoblastoma","volume":"49","author":"Bunin","year":"1989","journal-title":"Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/EDE.0000000000000107","article-title":"Residential proximity to major roads and term low birth weight: The roles of air pollution, heat, noise, and road-adjacent trees","volume":"25","author":"Dadvand","year":"2014","journal-title":"Epidemiology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/ijc.23645","article-title":"Perinatal characteristics and risk of neuroblastoma","volume":"123","author":"Johnson","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1476-069X-12-34","article-title":"Residential proximity to major roads and adverse birth outcomes: A hospital-based study","volume":"12","author":"Yorifuji","year":"2013","journal-title":"Environ. Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-069X-7-37","article-title":"A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio","volume":"7","author":"Jusko","year":"2008","journal-title":"Environ. Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.3390\/ijerph110202108","article-title":"Effects of age, season, gender and urban-rural status on time-activity: Canadian Human Activity Pattern Survey 2 (CHAPS 2)","volume":"11","author":"Matz","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Friedrich, P., Itriago, E., Rodriguez-Galindo, C., and Ribeiro, K. (2017). Racial and Ethnic Disparities in the Incidence of Pediatric Extracranial Embryonal Tumors. J. Natl. Cancer Inst., 109.","DOI":"10.1093\/jnci\/djx050"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1289\/ehp.1306761","article-title":"Childhood cancer and traffic-related air pollution exposure in pregnancy and early life","volume":"121","author":"Heck","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Azary, S., Ganguly, A., Bunin, G.R., Lombardi, C., Park, A.S., Ritz, B., and Heck, J.E. (2016). Sporadic Retinoblastoma and Parental Smoking and Alcohol Consumption before and after Conception: A Report from the Children\u2019s Oncology Group. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151728"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.taap.2003.12.028","article-title":"Nongenetic causes of childhood cancers: Evidence from international variation, time trends, and risk factor studies","volume":"199","author":"Bunin","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_28","unstructured":"Nasca, P.C., and Pastides, H. (2008). Childhood Cancer. Fundamentals of Cancer Epidemiology, Jones and Bartlett Publishers. [2nd ed.]."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1289\/ehp.1104056","article-title":"Prenatal exposure to polycyclic aromatic hydrocarbons, benzo[a]pyrene-DNA adducts, and genomic DNA methylation in cord blood","volume":"120","author":"Herbstman","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1158\/1055-9965.EPI-04-0457","article-title":"DNA damage from polycyclic aromatic hydrocarbons measured by benzo [a] pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center Area, Poland, and China","volume":"14","author":"Perera","year":"2005","journal-title":"Cancer Epidemiol. Prev. Biomark."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1349-7006.2004.tb03162.x","article-title":"Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1","volume":"95","author":"Shimada","year":"2004","journal-title":"Cancer Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10715760903300691","article-title":"Role of oxidative damage in toxicity of particulates","volume":"44","author":"Moller","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10555-006-9037-8","article-title":"The signaling mechanism of ROS in tumor progression","volume":"25","author":"Wu","year":"2006","journal-title":"Cancer Metastasis Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0048-9697(03)00228-6","article-title":"Ambient nitrogen dioxide and distance from a major highway","volume":"312","author":"Gilbert","year":"2003","journal-title":"Sci. Total Environ."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/jes.2015.63","article-title":"Differences in environmental exposure assignment due to residential mobility among children with a central nervous system tumor: Texas, 1995\u20132009","volume":"27","author":"Danysh","year":"2017","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1365-3016.2010.01096.x","article-title":"Differences in exposure assignment between conception and delivery: The impact of maternal mobility","volume":"24","author":"Lupo","year":"2010","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envres.2013.09.002","article-title":"An exploratory study of ambient air toxics exposure in pregnancy and the risk of neuroblastoma in offspring","volume":"127","author":"Heck","year":"2013","journal-title":"Environ. Res."},{"key":"ref_38","unstructured":"(2015, February 15). U.S. Environmental Protection Agency Toxics Release Inventory (TRI) Explorer (2012 Dataset) [Internet Database], Available online: http:\/\/www.epa.gov\/triexplorer."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/3\/505\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:56:49Z","timestamp":1760194609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/3\/505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,13]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["ijerph15030505"],"URL":"https:\/\/doi.org\/10.3390\/ijerph15030505","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,13]]}}}