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The association between \u201cInternet addiction\u201d and mental health has been well documented across a range of investigations. However, a major drawback of these studies is that no controls have been placed on the type of Internet use investigated. The aim of this study is to review systematically the current literature in order to explore the association between Internet Gaming Disorder (IGD) and psychopathology. An electronic literature search was conducted using PubMed, PsychINFO, ScienceDirect, Web of Science and Google Scholar (r.n. CRD42018082398). The effect sizes for the observed correlations were identified or computed. Twenty-four articles met the eligibility criteria. The studies included comprised 21 cross-sectional and three prospective designs. Most of the research was conducted in Europe. The significant correlations reported comprised: 92% between IGD and anxiety, 89% with depression, 85% with symptoms of attention deficit hyperactivity disorder (ADHD), and 75% with social phobia\/anxiety and obsessive-compulsive symptoms. Most of the studies reported higher rates of IGD in males. The lack of longitudinal studies and the contradictory results obtained prevent detection of the directionality of the associations and, furthermore, show the complex relationship between both phenomena.<\/jats:p>","DOI":"10.3390\/ijerph15040668","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T13:31:51Z","timestamp":1522762311000},"page":"668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":417,"title":["Association between Internet Gaming Disorder or Pathological Video-Game Use and Comorbid Psychopathology: A Comprehensive Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Vega","family":"Gonz\u00e1lez-Bueso","sequence":"first","affiliation":[{"name":"Atenci\u00f3n e Investigaci\u00f3n en Socioadicciones (AIS), Mental Health and Addictions Network, Generalitat de Catalunya (XHUB), C\/Forn-7-9 Local, 08014 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9957-9363","authenticated-orcid":false,"given":"Juan","family":"Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Atenci\u00f3n e Investigaci\u00f3n en Socioadicciones (AIS), Mental Health and Addictions Network, Generalitat de Catalunya (XHUB), C\/Forn-7-9 Local, 08014 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0012-2094","authenticated-orcid":false,"given":"Daniel","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Parc Sanitari Sant Joan de D\u00e9u, Fundaci\u00f3 Sant Joan de D\u00e9u, CIBERSAM, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, 08830 Barcelona, Spain"},{"name":"School of Mathematics and Statistics, Victoria University of Wellington, Wellington 6140, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Merino","sequence":"additional","affiliation":[{"name":"Atenci\u00f3n e Investigaci\u00f3n en Socioadicciones (AIS), Mental Health and Addictions Network, Generalitat de Catalunya (XHUB), C\/Forn-7-9 Local, 08014 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7371-2135","authenticated-orcid":false,"given":"Elena","family":"Montero","sequence":"additional","affiliation":[{"name":"Atenci\u00f3n e Investigaci\u00f3n en Socioadicciones (AIS), Mental Health and Addictions Network, Generalitat de Catalunya (XHUB), C\/Forn-7-9 Local, 08014 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Ribas","sequence":"additional","affiliation":[{"name":"Atenci\u00f3n e Investigaci\u00f3n en Socioadicciones (AIS), Mental Health and Addictions Network, Generalitat de Catalunya (XHUB), C\/Forn-7-9 Local, 08014 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cpr.2013.01.002","article-title":"Toward a consensus definition of pathological video-gaming: A systematic review of psychometric assessment tools","volume":"33","author":"King","year":"2013","journal-title":"Clin. 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