{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:03:03Z","timestamp":1790528583854,"version":"4.1.0"},"reference-count":68,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Patterns of vector-borne disease risk are changing globally in space and time and elevated disease risk of vector-borne infection can be driven by anthropogenic modification of the environment. Incidence of Lyme disease, caused by the bacterium Borrelia burgdorferi sensu stricto, has risen in a number of locations in North America and this increase may be driven by spatially or numerically expanding populations of the primary tick vector, Ixodes scapularis. We used a model selection approach to identify habitat fragmentation and land-use\/land cover variables to test the hypothesis that the amount and configuration of forest cover at spatial scales relevant to deer, the primary hosts of adult ticks, would be the predominant determinants of tick abundance. We expected that land cover heterogeneity and amount of forest edge, a habitat thought to facilitate deer foraging and survival, would be the strongest driver of tick density and that larger spatial scales (5\u201310 km) would be more important than smaller scales (1 km). We generated metrics of deciduous and mixed forest fragmentation using Fragstats 4.4 implemented in ArcMap 10.3 and found, after adjusting for multicollinearity, that total forest edge within a 5 km buffer had a significant negative effect on tick density and that the proportion of forested land cover within a 10 km buffer was positively associated with density of I. scapularis nymphs. None of the 1 km fragmentation metrics were found to significantly improve the fit of the model. Elevation, previously associated with increased density of I. scapularis nymphs in Virginia, while significantly predictive in univariate analysis, was not an important driver of nymph density relative to fragmentation metrics. Our results suggest that amount of forest cover (i.e., lack of fragmentation) is the most important driver of I. scapularis density in our study system.<\/jats:p>","DOI":"10.3390\/ijerph15040737","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T12:19:27Z","timestamp":1523535567000},"page":"737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Using Landscape Analysis to Test Hypotheses about Drivers of Tick Abundance and Infection Prevalence with Borrelia burgdorferi"],"prefix":"10.3390","volume":"15","author":[{"given":"A.","family":"Ferrell","sequence":"first","affiliation":[{"name":"Department of Biology, University of Richmond, 28 Westhampton Way, Richmond, VA 23173, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Brinkerhoff","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Richmond, 28 Westhampton Way, Richmond, VA 23173, USA"},{"name":"College of Life Sciences, University of KwaZulu-Natal, 3209 Pietermaritzburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.energy.21.1.125","article-title":"Global change and human susceptibility to disease","volume":"21","author":"Daily","year":"1996","journal-title":"Annu. Rev. Energy Environ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s10393-006-0036-6","article-title":"Changes in habitat suitability for the tick Ixodes ricinus (Acari: Ixodidae) in Europe (1900\u20131999)","volume":"3","author":"Venzal","year":"2006","journal-title":"Ecohealth"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/brv.12149","article-title":"Towards a resource-based habitat approach for spatial modelling of vector-borne disease risks","volume":"90","author":"Hartemink","year":"2015","journal-title":"Biol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e646","DOI":"10.1371\/journal.pntd.0000646","article-title":"Consequences of the Expanding Global Distribution of Aedes albopictus for Dengue Virus Transmission","volume":"4","author":"Lambrechts","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.pt.2016.04.015","article-title":"Effects of Climate and Climate Change on Vectors and Vector-Borne Diseases: Ticks Are Different","volume":"32","author":"Ogden","year":"2016","journal-title":"Trends Parasitol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0065-308X(00)47010-7","article-title":"Ticks and tick-borne disease systems in space and from space","volume":"47","author":"Randolph","year":"2000","journal-title":"Adv. Parasitol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1890\/0012-9658(2002)083[0255:CCAVAL]2.0.CO;2","article-title":"Comparing climate and vegetation as limiting factors for species ranges of African ticks","volume":"83","author":"Cumming","year":"2002","journal-title":"Ecology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.parepi.2016.03.003","article-title":"Macroecological patterns of American cutaneous leishmaniasis transmission across the health areas of Panama (1980\u20132012)","volume":"1","author":"Yamada","year":"2016","journal-title":"Parasite Epidemiol. Control"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1017\/S0031182000073741","article-title":"Vegetation structure influences the burden of immature Ixodes dammini on its main host, Peromyscus leucopus","volume":"105","author":"Adler","year":"1992","journal-title":"Parasitology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/jmedent\/36.6.741","article-title":"Impact of microclimate on immature tick-rodent host interactions (Acari: Ixodidae): Implications for parasite transmission","volume":"36","author":"Randolph","year":"1999","journal-title":"J. Med. Entomol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"824","DOI":"10.2307\/3285817","article-title":"Variation in the density of questing Ixodes pacificus (Acari: Ixodidae) nymphs infected with Borrelia burgdorferi at different spatial scales in California","volume":"85","author":"Lane","year":"1999","journal-title":"J. Parasitol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1603\/0022-2585-41.5.861","article-title":"Lack of spatial autocorrelation in fine-scale distributions of Ixodes scapularis (Acari: Ixodidae)","volume":"41","author":"Perdanani","year":"2004","journal-title":"J. Med. Entomol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/jmedent\/43.2.403","article-title":"Investigation of ground level and remote-sensed classification and prediction of survival of Ixodes scapularis in habitats of southeastern Canada","volume":"42","author":"Ogden","year":"2006","journal-title":"J. Med. Entomol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hamer, G.L., Chaves, L.F., Anderson, T.K., Kitron, U.D., Brawn, J.D., Ruiz, M.O., Loss, S.R., Walker, E.D., and Goldberg, T.L. (2011). Fine-scale variation in vector host use and force of infection drive localized patterns of west Nile virus transmission. PLoS ONE.","DOI":"10.1371\/journal.pone.0023767"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/jvec.12253","article-title":"Involvement of invasive eastern red cedar (Juniperus virginiana) in the expansion of Amblyomma americanum in Oklahoma","volume":"42","author":"Noden","year":"2017","journal-title":"J. Vector Ecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4081\/gh.2016.487","article-title":"Local landscape effects on population dynamics of Ixodes ricinus","volume":"11","author":"Asghar","year":"2016","journal-title":"Geospat. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13071-016-1938-y","article-title":"Lyme disease risk in southern California: Abiotic and environmental drivers of Ixodes pacificus (Acari: Ixodidae) density and infection prevalence with Borrelia burgdorferi","volume":"10","author":"MacDonald","year":"2017","journal-title":"Parasites Vectors"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13071-016-1296-9","article-title":"Effect of landscape features on the relationship between Ixodes ricinus ticks and their small mammal hosts","volume":"9","author":"Perez","year":"2016","journal-title":"Parasites Vectors"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1111\/1462-2920.13885","article-title":"Ecological factors influencing small mammal infection by Anaplasma phagocytophilum and Borrelia burgdorferi s.l. in agricultural and forest landscapes","volume":"19","author":"Perez","year":"2017","journal-title":"Environ. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1603\/ME10131","article-title":"Influence of abiotic and environmental factors on the density and infection prevalence of Ixodes pacificus (Acari: Ixodidae) with Borrelia burgdorferi","volume":"48","author":"Swei","year":"2011","journal-title":"J. Med. Entomol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/jme\/tjv237","article-title":"County-Scale Distribution of Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae) in the Continental United States","volume":"53","author":"Eisen","year":"2016","journal-title":"J. Med. Entomol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1128\/AEM.01982-07","article-title":"Role of migratory birds in introduction and range expansion of Ixodes scapularis ticks and of Borrelia burgdorferi and Anaplasma phagocytophilum in Canada","volume":"74","author":"Ogden","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1890\/090062","article-title":"Do birds affect Lyme disease risk? Range expansion of the vector-borne pathogen Borrelia burgdorferi","volume":"9","author":"Brinkerhoff","year":"2011","journal-title":"Front. Ecol. Environ."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1603\/0022-2585-41.5.842","article-title":"A dispersal model for the range expansion of blacklegged tick (Acari: Ixodidae)","volume":"41","author":"Madhav","year":"2004","journal-title":"J. Med. Entomol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1890\/ES11-00088.1","article-title":"Climatic variability and landscape heterogeneity impact urban mosquito diversity and vector abundance and infection","volume":"2","author":"Chaves","year":"2011","journal-title":"Ecosphere"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s00484-016-1162-7","article-title":"Globally invasive, withdrawing at home: Aedes albopictus and Aedes japonicus facing the rise of Aedes flavopictus","volume":"60","author":"Chaves","year":"2016","journal-title":"Int. J. Biometerol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6622a1","article-title":"Surveillance for Lyme Disease\u2014United States, 2008\u20132015","volume":"66","author":"Schwartz","year":"2017","journal-title":"MMWR Surveill. Summ."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.4269\/ajtmh.2012.11-0630","article-title":"Geographic Variation in the Relationship between Human Lyme Disease Incidence and Density of Infected Host-Seeking Ixodes scapularis Nymphs in the Eastern United States","volume":"86","author":"Pepin","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4269\/ajtmh.2012.11-0395","article-title":"Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States","volume":"86","author":"Hoen","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3201\/eid2010.130782","article-title":"Lyme disease, Virginia, USA, 2000\u20132011","volume":"20","author":"Brinkerhoff","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1139\/z00-172","article-title":"Biodiversity series: The function of biodiversity in the ecology of vector-borne zoonotic diseases","volume":"78","author":"Ostfeld","year":"2000","journal-title":"Can. J. Zool."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1046\/j.1523-1739.2003.01260.x","article-title":"Effect of Forest Fragmentation on Lyme Disease Risk","volume":"17","author":"Allan","year":"2003","journal-title":"Conserv. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1073\/pnas.0233733100","article-title":"The ecology of infectious disease: Effects of host diversity and community composition on Lyme disease risk","volume":"100","author":"LoGiudice","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20160117","DOI":"10.1098\/rstb.2016.0117","article-title":"Lyme disease ecology in a changing world: Consensus, uncertainty and critical gaps for improving control","volume":"372","author":"Kilpatrick","year":"2017","journal-title":"Phil. Trans. R. Soc. B"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/jmedent\/25.4.224","article-title":"Reduced Abundance of Immature Ixodes dammini (Acari: Ixodidae) Following Elimination of Deer","volume":"25","author":"Wilson","year":"1988","journal-title":"J. Med. Entomol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/jmedent\/30.6.1043","article-title":"Reduced Abundance of Ixodes scapularis (Acari: Ixodidae) and Lyme Disease Risk by Deer Exclusion","volume":"30","author":"Daniels","year":"1993","journal-title":"J. Med. Entomol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1603\/0022-2585-41.4.779","article-title":"Abundance of Ixodes scapularis (Acari: Ixodidae) After the Complete Removal of Deer from an Isolated Offshore Island, Endemic for Lyme Disease","volume":"41","author":"Rand","year":"2004","journal-title":"J. Med. Entomol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/jmedent\/44.5.752","article-title":"Effects of Reduced Deer Density on the Abundance of Ixodes scapularis (Acari: Ixodidae) and Lyme Disease Incidence in a Northern New Jersey Endemic Area","volume":"44","author":"Jordan","year":"2007","journal-title":"J. Med. Entomol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1890\/07-1047.1","article-title":"Impact of Host Community Composition on Lyme Disease Risk","volume":"89","author":"LoGiudice","year":"2008","journal-title":"Ecology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1017\/S0031182012000200","article-title":"Pangloss revisited: A critique of the dilution effect and the biodiversity-buffers-disease paradigm","volume":"139","author":"Randolph","year":"2012","journal-title":"Parasitology"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Newman, E.A., Eisen, L., Eisen, R.J., Fedorova, N., Hasty, J.M., Vaughn, C., and Lane, R.S. (2015). Borrelia burgdorferi sensu lato spirochetes in wild birds in northwestern California: Associations with ecological factors, bird behavior, and tick infestation. PLoS ONE.","DOI":"10.1371\/journal.pone.0118146"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/459610","article-title":"Measuring Fine-Scale White-Tailed Deer Movements and Environmental Influences Using GPS Collars","volume":"2010","author":"Webb","year":"2010","journal-title":"Int. J. Ecol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1644\/1545-1542(2005)86[623:FCIDDO]2.0.CO;2","article-title":"Forest Cover Influences Dispersal Distance of White-Tailed Deer","volume":"86","author":"Long","year":"2005","journal-title":"J. Mammal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2307\/2425468","article-title":"An Analysis of Dispersal in an Unmanipulated Population of Peromyscus leucopus","volume":"112","author":"Krohne","year":"1984","journal-title":"Am. Midl. Nat."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.4269\/ajtmh.13-0733","article-title":"Spatial and Temporal Emergence Pattern of Lyme Disease in Virginia","volume":"91","author":"Li","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Lantos, P.M., Nigrovic, L.E., Auwaerter, P.G., Fowler, V.G., Ruffin, F., Brinkerhoff, R.J., Reber, J., Williams, C., Broyhill, J., and Pan, W.K. (2015). Geographic Expansion of Lyme Disease in the Southeastern United States, 2000\u20132014. Open Forum Infect. Dis., 2, Available online: https:\/\/academic.oup.com\/ofid\/article\/2\/4\/ofv143\/2460356.","DOI":"10.1093\/ofid\/ofv143"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1466-8238.2010.00526.x","article-title":"Field and climate-based model for predicting the density of host-seeking nymphal Ixodes scapularis, an important vector of tick-borne disease agents in the eastern United States","volume":"19","author":"Cislo","year":"2010","journal-title":"Glob. Ecol. Biogeogr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.meegid.2014.05.022","article-title":"Population genetic structure of the Lyme disease vector Ixodes scapularis at an apparent spatial expansion front","volume":"27","author":"Kelly","year":"2014","journal-title":"Infect. Genet. Evol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s10393-015-1034-3","article-title":"An Examination of the Demographic and Environmental Variables Correlated with Lyme Disease Emergence in Virginia","volume":"12","author":"Seukep","year":"2015","journal-title":"EcoHealth"},{"key":"ref_50","first-page":"1","article-title":"Insects of Virginia 13. Ticks of Virginia (Acari, Megastigmata)","volume":"139","author":"Sonenshine","year":"1979","journal-title":"Va. Polytech. Inst. Res. Div. Bull."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1099\/mic.0.26944-0","article-title":"Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe","volume":"150","author":"Bunikis","year":"2004","journal-title":"Microbiology"},{"key":"ref_52","first-page":"345","article-title":"Completion of the 2011 National Land Cover Database for the conterminous United States-Representing a decade of land cover change information","volume":"81","author":"Homer","year":"2015","journal-title":"Photogramm. Eng. Remote Sens."},{"key":"ref_53","unstructured":"McGarigal, K., Cushman, S.A., and Ene, E. (2018, February 26). Fragstats v4: Spatial Pattern Analysis Program for Categorical and Continuous Maps. Available online: http:\/\/www.umass.edu\/landeco\/research\/fragstats\/fragstats.html."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ijresmar.2015.08.004","article-title":"Diagnosing harmful collinearity in moderated regressions: A roadmap","volume":"33","author":"Chennamaneni","year":"2016","journal-title":"Int. J. Res. Market."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s10393-013-0890-y","article-title":"Effects of landscape fragmentation and climate on Lyme disease incidence in the northeastern United States","volume":"10","author":"Tran","year":"2013","journal-title":"EcoHealth"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.apgeog.2015.08.001","article-title":"Spatial ecology, landscapes, and the geography of vector-borne disease: A multi-disciplinary review","volume":"63","author":"Jamison","year":"2015","journal-title":"Appl. Geogr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF00048285","article-title":"Nymphal survival and habitat distribution of Ixodes scapularis and Amblyomma americanum ticks (Acari: Ixodidae) on Fire Island, New York, USA","volume":"20","author":"Ginsberg","year":"1996","journal-title":"Exp. Appl. Acarol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1523-1739.1988.tb00199.x","article-title":"Forests Too Deer: Edge Effects in Northern Wisconsin","volume":"2","author":"Alverson","year":"1988","journal-title":"Conserv. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/aesa\/78.2.172","article-title":"Correlation between Abundance of Deer and That of the Deer Tick, Ixodes-Dammini (acari, Ixodidae)","volume":"78","author":"Wilson","year":"1985","journal-title":"Ann. Entomol. Soc. Am."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/jmedent\/30.6.986","article-title":"Reduced Abundance of Ixodes scapularis (Acari: Ixodidae) with Exclusion of Deer by Electric Fencing","volume":"30","author":"Stafford","year":"1993","journal-title":"J. Med. Entomol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00442-005-0251-9","article-title":"Durland Fish Forest Fragmentation Predicts Local Scale Heterogeneity of Lyme Disease Risk","volume":"146","author":"Brownstein","year":"2005","journal-title":"Oecologia"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zolnik, C.P., Falco, R.C., Kolokotronis, S.-O., and Daniels, T.J. (2015). No observed effect of landscape fragmentation on pathogen infection in blacklegged ticks (Ixodes scapularis) in the northeastern United States. PLoS ONE.","DOI":"10.1371\/journal.pone.0139473"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2307\/1382364","article-title":"Mammalian Abundances on Forest-Farm Edges versus Forest Interiors in Southern Illinois: Is There an Edge Effect?","volume":"76","author":"Heske","year":"1995","journal-title":"J. Mammal."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00265-009-0732-7","article-title":"A Patch Use Model to Separate Effects of Foraging Costs on Giving-up Densities: An Experiment with White-Tailed Deer (Odocoileus virginianus)","volume":"63","author":"Rieucau","year":"2009","journal-title":"Behav. Ecol. Sociobiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1756-3305-6-164","article-title":"Leishmaniasis sandfly vector density reduction is less marked in destitute housing after insecticide thermal fogging","volume":"6","author":"Chaves","year":"2013","journal-title":"Parasites Vectors"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1034\/j.1600-0587.2003.03530.x","article-title":"The relationships between habitat topology, critical scales of connectivity, and tick abundance Ixodes ricinus in a heterogeneous landscape in northern Spain","volume":"26","year":"2003","journal-title":"Ecography"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4081\/gh.2007.264","article-title":"A GIS framework for the assessment of tick impact on human health in a changing climate","volume":"1","author":"Venzal","year":"2007","journal-title":"Geospat. Health"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.amepre.2009.04.026","article-title":"Peridomestic Lyme Disease Prevention: Results of a Population-Based Case\u2013Control Study","volume":"37","author":"Connally","year":"2009","journal-title":"Am. J. Prev. Med."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/4\/737\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:00:28Z","timestamp":1760194828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/4\/737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,12]]},"references-count":68,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4]]}},"alternative-id":["ijerph15040737"],"URL":"https:\/\/doi.org\/10.3390\/ijerph15040737","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,12]]}}}