{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:00:28Z","timestamp":1773298828843,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The disability-adjusted life years (DALYs) were used to estimate the regional (state of Colima, Mexico) cancer burden in 2010\u20132014. The years of life lost (YLL) were estimated with mortality data and years lived with disability (YLD) using incidence data. The DALYs were calculated as the arithmetic addition of YLL and YLD. Sex and cancer site-specific estimations were made and DALY rates were used to identify the leading causes of disease burden. Data from 2532 deaths were analyzed and, for all malignant tumors combined, 18,712.9 DALYs and 20,243.3 DALYs were estimated in males and females respectively. The overall contribution of YLL in DALY estimates was higher among females (93.7% vs. 87.4%). Age-standardized DALY rates (and 95% confidence intervals, CI) per 100,000 inhabitants were used to rank the leading causes of disease burden and, among males, malignant tumors from the prostate, lower respiratory tract, and colon and rectum accounted the highest rates (45.7, 95% CI 32.7\u201359.3; 37.6, 95% CI 25.7\u201349.9; and 25.9, 95% CI 16.0\u201336.1 DALYs). Breast, cervix uteri, and lower respiratory tract cancer showed the highest burden in females (66.0, 95% CI 50.3\u201382.4; 44.4, 95% CI 31.5\u201357.7; and 20.9, 95% CI 12.0\u201330.0 DALYs). The present study provides an indication of the burden of cancer at the regional level, underscoring the need to expand cancer prevention, screening, and awareness programs, as well as to improve early diagnosis and medical treatment.<\/jats:p>","DOI":"10.3390\/ijerph15050864","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T06:52:23Z","timestamp":1524811943000},"page":"864","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Disability-Adjusted Life Years for Cancer in 2010\u20132014: A Regional Approach in Mexico"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-498X","authenticated-orcid":false,"given":"Efr\u00e9n","family":"Murillo-Zamora","sequence":"first","affiliation":[{"name":"Unidad de Medicina Familiar No. 19, Instituto Mexicano del Seguro Social, Av. Javier Mina 301, Col. Centro, Colima 28000, Colima, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-4946","authenticated-orcid":false,"given":"Oliver","family":"Mendoza-Cano","sequence":"additional","affiliation":[{"name":"Facultad de Ingenier\u00eda Civil, Universidad de Colima, Km. 9.0 Carretera Colima-Coquimatl\u00e1n, Coquimatl\u00e1n 28400, Colima, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-4619","authenticated-orcid":false,"given":"M\u00f3nica","family":"R\u00edos-Silva","sequence":"additional","affiliation":[{"name":"Profesora Investigadora C\u00e1tedras CONACyT-Universidad de Colima, Centro Universitario de Investigaciones Biom\u00e9dicas, Colima 28040, Colima, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n Alberto","family":"S\u00e1nchez-Pi\u00f1a","sequence":"additional","affiliation":[{"name":"Center for Health and the Global Environment, Department of Environmental Health, Harvard TH Chan School of Public Health, 401 Park Drive, P.O. Box 15677, 4th Floor West, Suite 415, Boston, MA 02215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha Alicia","family":"Higareda-Almaraz","sequence":"additional","affiliation":[{"name":"Jefatura de Servicios de Prestaciones M\u00e9dicas, Instituto Mexicano del Seguro Social, \u00c1lvaro Obreg\u00f3n 184, Col. Centro, Colima 28000, Colima, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Higareda-Almaraz","sequence":"additional","affiliation":[{"name":"Jefatura de Servicios de Prestaciones M\u00e9dicas, Instituto Mexicano del Seguro Social, \u00c1lvaro Obreg\u00f3n 184, Col. Centro, Colima 28000, Colima, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustin","family":"Lugo-Radillo","sequence":"additional","affiliation":[{"name":"CONACYT-Facultad de Medicina y Cirug\u00eda, Universidad Aut\u00f3noma Benito Ju\u00e1rez de Oaxaca, Ex Hacienda de Aguilera S\/N, Carretera a San Felipe del Agua, Oaxaca 68020, Oaxaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jhealeco.2010.07.001","article-title":"Health, aging and childhood socio-economic conditions in Mexico","volume":"29","author":"Grimard","year":"2010","journal-title":"J. Health Econ."},{"key":"ref_2","unstructured":"Media Centre\u2013IARC News (2018, February 02). World Cancer Day 2016. \u2018We Can. I Can\u2019. 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