{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:05:05Z","timestamp":1792789505298,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,5,6]],"date-time":"2018-05-06T00:00:00Z","timestamp":1525564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Health International Exchange Program","award":["JSH-2017-003"],"award-info":[{"award-number":["JSH-2017-003"]}]},{"name":"Key Talent Project for Medical Young Scholar of Jiangsu Province","award":["QNRC2016551"],"award-info":[{"award-number":["QNRC2016551"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The epidemiological features of Cryptosporidium infection among school-age children in China still remain unclear. Hereby, a cross-sectional study of 1637 children aged 3\u20139 years was designed to investigate the risk factors and spatial clusters of Cryptosporidium infection in a rural region of Eastern China. Stool specimens collected from participants were examined using the auramine-phenol and modified acid-fast staining. Univariable and multivariable analyses were performed to identify the risk factors of Cryptospordium infection. The spatial clusters were analyzed by a discrete Poisson model using SaTScan software. Our results showed that the overall prevalence of Cryptosporidium infection was 11\u2030 in the research region. At the age of 3\u20136 years (odds ratios (OR) = 3.072, 95% confidence intervals (CI): 1.001\u20139.427), not washing hands before eating and after defecation (OR = 3.003, 95% CI: 1.060\u20138.511) were recognized as risk factors. Furthermore, a high-risk spatial cluster (relative risk = 4.220, p = 0.025) was identified. These findings call for effective sustainable interventions including family and school-based hygienic education to reduce the prevalence of Cryptosporidium infection. Therefore, an early warning system based spatiotemporal models with risk factors is required to further improve the effectiveness and efficiency of cryptosporidiosis control in the future.<\/jats:p>","DOI":"10.3390\/ijerph15050924","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T03:12:21Z","timestamp":1525662741000},"page":"924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk Factors and Spatial Clusters of Cryptosporidium Infection among School-Age Children in a Rural Region of Eastern China"],"prefix":"10.3390","volume":"15","author":[{"given":"Hao","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Jintan Center for Disease Control and Prevention, Changzhou 213200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for Rural Water Supply Technical Guidance, Chinese Center for Disease Control and Prevention, Beijing 102200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Center for Rural Water Supply Technical Guidance, Chinese Center for Disease Control and Prevention, Beijing 102200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbiao","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Public Health and Social Work, Queensland University of Technology, Brisbane, Queensland 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1086\/652141","article-title":"Cryptosporidiosis and the ears of the hippopotamus","volume":"50","author":"White","year":"2010","journal-title":"Clin. 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