{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:59:07Z","timestamp":1760241547231,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"World Association of Infectious Diseases and Immunologcal Disorders","award":["WAidid2017_02"],"award-info":[{"award-number":["WAidid2017_02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Introduction: Phylloides tumours (PTs) are rare fibroepithelial neoplasms that account for 0.3\u20130.9% of all breast tumours. These tumours typically occur in women aged 30\u201370 years. The occurrence of these tumours in older children and adolescents poses particular diagnostic and therapeutic problems. However, early diagnosis is mandatory because although most of the cases of PTs in children are benign, the borderline and malignant cases with potential negative outcomes cannot be excluded. Case presentation: A 12-year-old girl presented at the Paediatric Emergency Department for hyperaemia and warmth of the left breast that occurred a few days prior without fever. The girl experienced menarche 8 months previously. She experienced no previous trauma and she had no family history of breast cancer. On physical examination, the left breast was painful, enlarged and tender. The overlying skin was erythematous and warm. A breast ultrasonography (US) revealed a large mass with features of an abscess, including a hyperechoic wall, scattered internal echoes and hypoechoic peripheral lacunae of apparent colliquative nature. After 4 days of unsuccessful antibiotic therapy, surgical drainage was performed due to the suspicion of a mammary abscess. At the surgical incision site, the lesion was not-well circumscribed and lacked a capsule. In addition, purulent material was not detected. Histological examination revealed that the tissue alterations were compatible with benign PT. With this diagnosis, the girl underwent definitive surgical removal of the lesion. The postoperative period passed without negative events. An US performed 6 months later revealed that no new mass was present at this time, suggesting no recurrence of the tumour. Conclusion: This case shows that in the presence of a clinical picture suggesting the inflammation of the breast in adolescent females, PT should be considered as a possible diagnosis and US-guided core biopsy should be considered to confirm this suspicion. Thereafter, when surgical excision is performed, particular attention must be paid to both the preservation of all the normal breast parenchyma and future aesthetic problems.<\/jats:p>","DOI":"10.3390\/ijerph15050959","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T03:42:48Z","timestamp":1526010168000},"page":"959","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inflamed Phylloides Tumour in a Girl: A Challenging Diagnosis in Paediatric Breast Lesions"],"prefix":"10.3390","volume":"15","author":[{"given":"Ilaria","family":"Testa","sequence":"first","affiliation":[{"name":"Paediatric Clinic, Department of Surgical and Biomedical Sciences, Universit\u00e0 degli Studi di Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Salvatori","sequence":"additional","affiliation":[{"name":"Paediatric Clinic, Department of Surgical and Biomedical Sciences, Universit\u00e0 degli Studi di Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Prestipino","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, S. Maria della Misericordia Hospital, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Section of Pathologic Anatomy and Histology, Department of Experimental Medicine, Universit\u00e0 degli Studi di Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Gerli","sequence":"additional","affiliation":[{"name":"S.S. Oncoplastic Surgery-Breast Unit, S. Maria della Misericordia Hospital, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-6774","authenticated-orcid":false,"given":"Giuseppe","family":"Di Cara","sequence":"additional","affiliation":[{"name":"Paediatric Clinic, Department of Surgical and Biomedical Sciences, Universit\u00e0 degli Studi di Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Principi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4103-2837","authenticated-orcid":false,"given":"Susanna","family":"Esposito","sequence":"additional","affiliation":[{"name":"Paediatric Clinic, Department of Surgical and Biomedical Sciences, Universit\u00e0 degli Studi di Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Bertozzi","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, S. Maria della Misericordia Hospital, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Co, M., Chen, C., Tsang, J.Y., Tse, G., and Kwong, A. (2017). Mammary phyllodes tumour: A 15-year multicentre clinical review. J. Clin. Pathol.","DOI":"10.1136\/jclinpath-2017-204827"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/pmj.77.909.428","article-title":"Phyllodes tumours","volume":"77","author":"Parker","year":"2001","journal-title":"Postgrad. Med. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"W204","DOI":"10.2214\/AJR.12.9560","article-title":"Pediatric and adolescent breast masses: A review of pathophysiology, imaging, diagnosis, and treatment","volume":"200","author":"Kaneda","year":"2013","journal-title":"Am. J. Roentgenol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1053\/jpsu.2001.23994","article-title":"Unusual clinical presentation of a rare case of phyllodes tumor of the breast in an adolescent girl","volume":"36","author":"Martino","year":"2001","journal-title":"J. Pediatr. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jpag.2007.11.006","article-title":"A phyllodes tumor in a child","volume":"22","author":"Pistolese","year":"2009","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_6","first-page":"89","article-title":"Cystosarcoma phyllodes in a 13-year-old Muslim girl treated with conservative surgery: A case report","volume":"24","author":"Galazios","year":"2003","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijpam.2016.03.005","article-title":"An adolescent with phyllodes tumour: Case report and review","volume":"3","author":"Makhija","year":"2016","journal-title":"Int. J. Pediatr. Adolesc. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4172\/2165-7920.1000495","article-title":"Childhood phyllodes tumour of the breast","volume":"5","author":"Akakpo","year":"2015","journal-title":"J. Clin. Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12282-009-0114-z","article-title":"Phyllodes tumor of the breast: An update","volume":"17","author":"Tse","year":"2010","journal-title":"Breast Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/his.12876","article-title":"Phyllodes tumours of the breast: A consensus review","volume":"68","author":"Tan","year":"2016","journal-title":"Histopathology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jss.2008.03.026","article-title":"Malignant breast cancer in children: A review of 75 patients","volume":"147","author":"Gutierrez","year":"2008","journal-title":"J. Surg. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1097\/MPH.0b013e3182a6d4a4","article-title":"Phyllodes tumor in survivors of childhood osteosarcoma: A single institution\u2019s experience","volume":"36","author":"Jaing","year":"2014","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1016\/j.clml.2014.06.106","article-title":"A strange case of phyllodes tumor detected using (18)F-FDG PET\/CT in an adolescent patient affected by Hodgkin lymphoma: A possible pitfall","volume":"14","author":"Cucinotta","year":"2014","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1016\/j.jpag.2006.11.005","article-title":"Occurrence of two rare malignant neoplasms (breast and ovarian) in an adolescent female","volume":"22","author":"Jayasinghe","year":"2009","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/MPH.0000000000000197","article-title":"More on osteosarcoma and phylloides tumor","volume":"37","author":"Bielack","year":"2015","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/A:1026487120779","article-title":"Human breast development","volume":"5","author":"Howard","year":"2000","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"ref_17","first-page":"312","article-title":"Giant juvenile fibroadenoma: A systematic review with diagnostic and treatment recommendations","volume":"4","author":"Sosin","year":"2015","journal-title":"Gland Surg."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kalambo, M., Adrada, B.E., Adeyefa, M.M., Krishnamurthy, S., Hess, K., Carkaci, S., and Whitman, G.J. (2018). Phyllodes tumour of the breast: Ultrasound-pathology correlation. Am. J. Roentgenol.","DOI":"10.2214\/AJR.17.18554"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.2214\/ajr.181.5.1811267","article-title":"Characterization of lesions of the breast with proton MR spectroscopy: Comparison of carcinomas, benign lesions, and phyllodes tumors","volume":"181","author":"Tse","year":"2003","journal-title":"Am. J. Roentgenol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18639\/ONBT.2016.03.1257","article-title":"Phyllodes tumor of the breast: Inside the sheep\u2019s skin","volume":"3","author":"Wadasadawala","year":"2016","journal-title":"Oncol. Targets"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/5\/959\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:04:12Z","timestamp":1760195052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/5\/959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,11]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5]]}},"alternative-id":["ijerph15050959"],"URL":"https:\/\/doi.org\/10.3390\/ijerph15050959","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2018,5,11]]}}}