{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:08:12Z","timestamp":1788984492255,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vagelos College of Physicians &amp; Surgeons"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Lyme disease (LD) is a commonly cited model for the link between habitat loss and\/or fragmentation and disease emergence, based in part on studies showing that forest patch size is negatively related to LD entomological risk. An equivalent relationship has not, however, been shown between patch size and LD incidence (LDI). Because entomological risk is measured at the patch scale, while LDI is generally assessed in relation to aggregate landscape statistics such as forest cover, we posit that the contribution of individual patches to human LD risk has not yet been directly evaluated. We design a model that directly links theoretical entomological risk at the patch scale to larger-scale epidemiological data. We evaluate its predictions for relative LD risk in artificial landscapes with varying composition and configuration, and test its ability to predict countywide LDI in a 12-county region of New York. On simulated landscapes, we find that the model predicts a unimodal relationship between LD incidence and forest cover, mean patch size, and mean minimum distance (a measure of isolation), and a protective effect for percolation probability (a measure of connectivity). In New York, risk indices generated by this model are significantly related to countywide LDI. The results suggest that the lack of concordance between entomological risk and LDI may be partially resolved by this style of model.<\/jats:p>","DOI":"10.3390\/ijerph15051048","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T03:14:24Z","timestamp":1527045264000},"page":"1048","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Reconciling the Entomological Hazard and Disease Risk in the Lyme Disease System"],"prefix":"10.3390","volume":"15","author":[{"given":"Max","family":"McClure","sequence":"first","affiliation":[{"name":"Vagelos College of Physicians &amp; Surgeons, Columbia University, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Diuk-Wasser","sequence":"additional","affiliation":[{"name":"Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY 10027, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (2017, December 01). County-Level Lyme Disease Data from 2000\u20132016, Available online: https:\/\/www.cdc.gov\/lyme\/stats\/index.html."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI21681","article-title":"The emergence of Lyme disease","volume":"113","author":"Steere","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.mm6453a1","article-title":"Summary of Notifiable Infectious Diseases and Conditions\u2014United States, 2015","volume":"64","author":"Adams","year":"2017","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.14745\/ccdr.v40i05a01","article-title":"Environmental risk from Lyme disease in central and eastern Canada: A summary of recent surveillance information","volume":"40","author":"Ogden","year":"2014","journal-title":"Can. Commun. Dis. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"20160117","DOI":"10.1098\/rstb.2016.0117","article-title":"Lyme disease ecology in a changing world: Consensus, uncertainty and critical gaps for improving control","volume":"372","author":"Kilpatrick","year":"2017","journal-title":"Philos. Trans. R. Soc. B"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gray, J.S., Kahl, O., Lane, R.S., and Stanek, G. (2002). Ecology of Borrelia burgdorferi sensu lato in North America. Lyme Borreliosis: Biology, Epidemiology, and Control, CAB International.","DOI":"10.1079\/9780851996325.0000"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jtbi.2010.10.011","article-title":"Loop analysis for pathogens: Niche partitioning in the transmission graph for pathogens of the North American tick Ixodes scapularis","volume":"269","author":"Davis","year":"2011","journal-title":"J. Theor. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ripoche, M., Gasmi, S., Adam-Poupart, A., Koffi, J.K., Lindsay, L.R., Ludwig, A., Milord, F., Ogden, N.H., Thivierge, K., and Leighton, P.A. (2018). Passive Tick Surveillance Provides an Accurate Early Signal of Emerging Lyme Disease Risk and Human Cases in Southern Canada. J. Med. Entomol.","DOI":"10.1093\/jme\/tjy030"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1046\/j.1523-1739.2003.01260.x","article-title":"Effect of Forest Fragmentation on Lyme Disease Risk","volume":"17","author":"Allan","year":"2003","journal-title":"Conserv. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00442-005-0251-9","article-title":"Forest fragmentation predicts local scale heterogeneity of Lyme disease risk","volume":"146","author":"Brownstein","year":"2005","journal-title":"Oecologia"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zolnik, C.P., Falco, R.C., Kolokotronis, S.-O., and Daniels, T.J. (2015). No observed effect of landscape fragmentation on pathogen infection prevalence in blacklegged ticks (Ixodes scapularis) in the Northeastern United States. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139473"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1890\/07-1047.1","article-title":"Impact of host community composition on Lyme disease risk","volume":"89","author":"LoGiudice","year":"2008","journal-title":"Ecology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1007965600166","article-title":"Landscape features associated with Lyme disease risk in a suburban residential environment","volume":"13","author":"Frank","year":"1998","journal-title":"Landsc. Ecol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Li, S., Hartemink, N., Speybroeck, N., and Vanwambeke, S.O. (2012). Consequences of Landscape Fragmentation on Lyme Disease Risk: A Cellular Automata Approach. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039612"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"20160129","DOI":"10.1098\/rstb.2016.0129","article-title":"Does the impact of biodiversity differ between emerging and endemic pathogens? The need to separate the concepts of hazard and risk","volume":"372","author":"Hosseini","year":"2017","journal-title":"Philos. Trans. R. Soc. B"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Finch, C., Al-Damluji, M.S., Krause, P.J., Niccolai, L., Steeves, T., O\u2019Keefe, C.F., and Diuk-Wasser, M.A. (2014). Integrated assessment of behavioral and environmental risk factors for Lyme disease infection on Block Island, Rhode Island. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0084758"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ttbdis.2016.10.006","article-title":"Exposure and preventive behaviours toward ticks and Lyme disease in Canada: Results from a first national survey","volume":"8","author":"Aenishaenslin","year":"2017","journal-title":"Ticks Tick Borne Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3201\/eid2109.150417","article-title":"Incidence of clinician-diagnosed Lyme disease, United States, 2005\u20132010","volume":"21","author":"Nelson","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3201\/eid1302\/130644","article-title":"Monitoring human babesiosis emergence through vector surveillance New England, USA","volume":"20","author":"Liu","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.4269\/ajtmh.2012.11-0630","article-title":"Geographic variation in the relationship between human Lyme disease incidence and density of infected host-seeking Ixodes scapularis nymphs in the Eastern United States","volume":"86","author":"Pepin","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3376\/1081-1710(2006)31[364:APEFAP]2.0.CO;2","article-title":"Assessing peridomestic entomological factors as predictors for Lyme disease","volume":"31","author":"Connally","year":"2006","journal-title":"J. Vector Ecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tree.2012.10.011","article-title":"Biodiversity and disease: A synthesis of ecological perspectives on Lyme disease transmission","volume":"28","author":"Wood","year":"2013","journal-title":"Trends Ecol. Evol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/ije\/dyi284","article-title":"Towards landscape design guidelines for reducing Lyme disease risk","volume":"35","author":"Jackson","year":"2006","journal-title":"Int. J. Epidemiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/oxfordjournals.aje.a115057","article-title":"Ticks parasitizing humans in a Lyme disease endemic area of southern New York State","volume":"128","author":"Falco","year":"1988","journal-title":"Am. J. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1023\/A:1008107902848","article-title":"Landscape patterns simulation with a modified random clusters method","volume":"15","author":"Saura","year":"2000","journal-title":"Landsc. Ecol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Gutzwiller, K. (2002). Using percolation theory to assess landscape connectivity and effects of habitat fragmentation. Applying Landscape Ecology in Biological Conservation, Springer Science+Business Media.","DOI":"10.1007\/978-1-4613-0059-5"},{"key":"ref_27","first-page":"345","article-title":"Completion of the 2011 National Land Cover Database for the conterminous United States\u2013representing a decade of land cover change information","volume":"81","author":"Homer","year":"2015","journal-title":"Photogramm. Eng. Remote Sens."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"747","DOI":"10.4269\/ajtmh.14-0181","article-title":"Lyme Disease Risk Influences Human Settlement in the Wildland\u2013Urban Interface: Evidence from a Longitudinal Analysis of Counties in the Northeastern United States","volume":"91","author":"Larsen","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_29","unstructured":"NYS (2017, December 01). Civil Boundaries Data, Available online: http:\/\/gis.ny.gov\/gisdata\/inventories\/details.cfm?DSID=927."},{"key":"ref_30","unstructured":"NNDSS (2017, December 01). National Notifiable Disease Surveillance System Surveillance Case Definitions, Lyme Disease (Borrelia burgdorferi), Available online: http:\/\/www.cdc.gov\/nndss\/conditions\/lyme-disease\/."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Waller, L.A., and Gotway, C.A. (2004). Applied Spatial Statistics for Public Health Data, John Wiley & Sons.","DOI":"10.1002\/0471662682"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Dale, M.R., and Fortin, M.-J. (2014). Spatial Analysis: A Guide for Ecologists, Cambridge University Press.","DOI":"10.1017\/CBO9780511978913"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1046\/j.1523-1739.2000.99014.x","article-title":"Biodiversity and disease risk: The case of Lyme disease","volume":"14","author":"Ostfeld","year":"2000","journal-title":"Conserv. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1890\/0012-9658(2001)082[0609:BATDEI]2.0.CO;2","article-title":"Biodiversity and the dilution effect in disease ecology","volume":"82","author":"Schmidt","year":"2001","journal-title":"Ecology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1073\/pnas.0233733100","article-title":"The ecology of infectious disease: Effects of host diversity and community composition on Lyme disease risk","volume":"100","author":"LoGiudice","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2307\/2407089","article-title":"An equilibrium theory of insular zoogeography","volume":"17","author":"MacArthur","year":"1963","journal-title":"Evolution"},{"key":"ref_37","first-page":"722","article-title":"It\u2019s a myth that protection against disease is a strong and general service of biodiversity conservation: Response to Ostfeld and Keesing","volume":"14","author":"Lafferty","year":"2013","journal-title":"Conserv. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1017\/S0031182013000620","article-title":"Commentary on \u2018A Candide response to Panglossian accusations by Randolph and Dobson: Biodiversity buffers disease\u2019 by Dr. R. Ostfeld (Parasitology 2013, in press)","volume":"140","author":"Randolph","year":"2013","journal-title":"Parasitology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1017\/S0031182012000200","article-title":"Pangloss revisited: A critique of the dilution effect and the biodiversity-buffers-disease paradigm","volume":"139","author":"Randolph","year":"2012","journal-title":"Parasitology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.tree.2013.05.009","article-title":"Straw men don\u2019t get Lyme disease: Response to Wood and Lafferty","volume":"28","author":"Ostfeld","year":"2013","journal-title":"Trends Ecol. Evol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Linske, M.A., Williams, S.C., Stafford, K.C., and Ortega, I.M. (2018). Ixodes scapularis (Acari: Ixodidae) Reservoir Host Diversity and Abundance Impacts on Dilution of Borrelia burgdorferi (Spirochaetales: Spirochaetaceae) in Residential and Woodland Habitats in Connecticut, United States. J. Med. Entomol.","DOI":"10.1093\/jme\/tjx237"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"47008","DOI":"10.1289\/EHP1943","article-title":"Integrated Social-Behavioral and Ecological Risk Maps to Prioritize Local Public Health Responses to Lyme Disease","volume":"126","author":"Bouchard","year":"2018","journal-title":"Environ. Health Perspect."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/5\/1048\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:05:27Z","timestamp":1760195127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/5\/1048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,22]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5]]}},"alternative-id":["ijerph15051048"],"URL":"https:\/\/doi.org\/10.3390\/ijerph15051048","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,22]]}}}