{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:45:45Z","timestamp":1790520345956,"version":"4.1.0"},"reference-count":291,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Contact allergy is common, affecting 27% of the general population in Europe. Original publications, including case reports, published since 2016 (inclusive) were identified with the aim of collating a full review of current problems in the field. To this end, a literature search employing methods of systematic reviewing was performed in the Medline\u00ae and Web of Science\u2122 databases on 28 January 2018, using the search terms (\u201ccontact sensitization\u201d or \u201ccontact allergy\u201d). Of 446 non-duplicate publications identified by above search, 147 were excluded based on scrutiny of title, abstract and key words. Of the remaining 299 examined in full text, 291 were deemed appropriate for inclusion, and main findings were summarised in topic sections. In conclusion, diverse sources of exposures to chemicals of widely-differing types and structures, continue to induce sensitisation in man and may result in allergic contact dermatitis. Many of the chemicals are \u201cevergreen\u201d but others are \u201cnewcomers\u201d. Vigilance and proper investigation (patch testing) are required to detect and inform of the presence of these haptens to which our populations remain exposed.<\/jats:p>","DOI":"10.3390\/ijerph15061108","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T03:04:27Z","timestamp":1527649467000},"page":"1108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Contact Allergy: A Review of Current Problems from a Clinical Perspective"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-3710","authenticated-orcid":false,"given":"Wolfgang","family":"Uter","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen\/N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Werfel","sequence":"additional","affiliation":[{"name":"Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[{"name":"St John\u2019s Institute of Dermatology, Guy\u2019s Hospital, London SE1 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, National Allergy Research Centre, Copenhagen University Hospital Herlev and Gentofte, 2900 Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/cod.12432","article-title":"European Society of Contact Dermatitis guideline for diagnostic patch testing\u2014Recommendations on best practice","volume":"73","author":"Johansen","year":"2015","journal-title":"Contact Dermat."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/bjd.14167","article-title":"Prevalence of contact allergy in the general population in different European regions","volume":"174","author":"Diepgen","year":"2016","journal-title":"Br. 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