{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:54:29Z","timestamp":1780498469880,"version":"3.54.1"},"reference-count":61,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"World Association of Infectious Diseases and Immunological Disorders (WAidid)","award":["WAidid 2017_02"],"award-info":[{"award-number":["WAidid 2017_02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Hypereosinophilia in children can be primary or secondary. Numerous malignant diseases can cause hypereosinophilia, but it is seldom caused by acute lymphoblastic leukemia (ALL). In the event of protracted hypereosinophilia, it is extremely important to make a correct differential diagnosis. Case presentation: We present the case of an 11-year-old boy of Moroccan origin with ALL with hypereosinophilic onset (eosinophils in peripheral blood, 10,000\/\u00b5L) in the absence of other signs of neoplastic disease, and compare this case with 61 similar cases in the literature. Following hospital admission, the patient initially presented with headache-caused nocturnal awakenings, evening fever, and cough, and he also lost approximately 7 kg in weight in a month not associated with sweating or itching. We first performed bone marrow aspiration, which showed an increase in eosinophils without cellular morphological abnormalities, and bone marrow immunophenotyping showed that 4.5% of cells had a phenotype compatible with lymphoid blasts. A lumbar puncture was negative. Given the poor marrow involvement, it was necessary to repeat a new bone marrow aspiration two days later, which showed an increase in blasts to 14%. A concomitant bone marrow biopsy showed an infiltration of blasts typical of B-cell ALL equal to 20\u201330% with associated hypereosinophilia. Cytogenetic analysis showed an hyperdiploid karyotype: 53\u201355, XY, +X, add(1)(q21q25), +4, +9, +10, +14, +2, +1, +21\/46, XY. Conclusions: ALL is one of the possible causes of persistent hypereosinophilia. In patients with ALL and hypereosinophilia, peripheral hypereosinophilia can precede the appearance of blasts. Due to the negative prognosis and the increased risk of complications in these patients, bone marrow aspiration and biopsy are recommended if common causes of secondary hypereosinophilia are excluded.<\/jats:p>","DOI":"10.3390\/ijerph15061169","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T12:14:30Z","timestamp":1528114470000},"page":"1169","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Acute Lymphoblastic Leukemia with Hypereosinophilia in a Child: Case Report and Literature Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Valentina","family":"Ferruzzi","sequence":"first","affiliation":[{"name":"Pediatric Clinic, Department of Surgical and Biomedical Sciences, Universit\u00e0 degli Studi di Perugia, Piazza Menghini 1, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Santi","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, Department of Surgical and Biomedical Sciences, Universit\u00e0 degli Studi di Perugia, Piazza Menghini 1, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Gurdo","sequence":"additional","affiliation":[{"name":"Pediatric Oncohematology Unit, Azienda Ospedaliera, Piazza Menghini 1, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Arcioni","sequence":"additional","affiliation":[{"name":"Pediatric Oncohematology Unit, Azienda Ospedaliera, Piazza Menghini 1, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Caniglia","sequence":"additional","affiliation":[{"name":"Pediatric Oncohematology Unit, Azienda Ospedaliera, Piazza Menghini 1, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4103-2837","authenticated-orcid":false,"given":"Susanna","family":"Esposito","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, Department of Surgical and Biomedical Sciences, Universit\u00e0 degli Studi di Perugia, Piazza Menghini 1, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/ajh.24880","article-title":"World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management","volume":"92","author":"Gotlib","year":"2015","journal-title":"Am. J. Hematol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/MPH.0b013e318290bf0b","article-title":"Severe eosinophilia in children: A diagnostic dilemma","volume":"35","author":"Amshalom","year":"2013","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_3","first-page":"221","article-title":"Rash and eosinophilia in a 23-year-old man","volume":"137","author":"Bachhuber","year":"1982","journal-title":"West. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood.V42.3.377.377","article-title":"Lymphoblastic leukemia with marked eosinophilia: A report of two cases","volume":"42","author":"Spitzer","year":"1973","journal-title":"Blood"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1824-7288-40-36","article-title":"Hypereosoinophilia in childhood acute lymphoblastic leukemia at diagnosis: Report of 2 cases and review of the literature","volume":"40","author":"Parasole","year":"2014","journal-title":"Ital. J. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fmed.2017.00216","article-title":"(A Critical Appraisal of) Classification of Hypereosinophilic Disorders","volume":"4","author":"Kahn","year":"2017","journal-title":"Front. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3324\/haematol.2009.010421","article-title":"Hypereosinophilic syndrome variants: Diagnostic and therapeutic considerations","volume":"94","author":"Roufosse","year":"2009","journal-title":"Haematologica"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1200\/JCO.1987.5.3.382","article-title":"Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: Case report and literature review","volume":"5","author":"Hogan","year":"1987","journal-title":"J. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1182\/blood.V73.8.2081.2081","article-title":"The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene","volume":"73","author":"Grimaldi","year":"1989","journal-title":"Blood"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1182\/blood.V76.2.285.285","article-title":"Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia","volume":"76","author":"Meeker","year":"1990","journal-title":"Blood"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bcmd.2016.08.004","article-title":"Acute lymphoblastic leukemia presenting with hypereosinophilia: Case report and review of the literature","volume":"65","author":"Ali","year":"2017","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/pbc.25318","article-title":"Cutaneous B-lymphoblastic lymphoma with IL3\/IgH translocation presenting with hypereosinophilia and acute endocarditis","volume":"62","author":"Bomken","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s12288-014-0436-7","article-title":"Hypereosinophilia in Acute Lymphoblastic Leukemia: Two Cases with Review of Literature","volume":"31","author":"Sahu","year":"2015","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/ejh.12333","article-title":"Acute multilineage (B\/myeloid) leukemia with RUNX1 duplication\/amplification and hypereosinophilia","volume":"93","author":"Holmes","year":"2014","journal-title":"Eur. J. Haematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.12659\/AJCR.883905","article-title":"Eosinophilic presentation of acute lymphoblastic leukemia","volume":"14","author":"Rezamand","year":"2013","journal-title":"Am. J. Case Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000333085","article-title":"Does Hypereosinophilic Syndrome Precede Common B Acute Lymphoblastic Leukemia in Childhood? A Case Report","volume":"127","author":"Ayhan","year":"2012","journal-title":"Acta Haematol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1442-200X.2011.03471.x","article-title":"Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression","volume":"54","author":"Kobayashi","year":"2012","journal-title":"Pediatr. Int."},{"key":"ref_18","first-page":"131","article-title":"Childhood acute lymphoblastic leukemia with hypereosinophilia: Two cases and literature review","volume":"33","author":"Guo","year":"2012","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2141.2012.09098.x","article-title":"Loeffler myocarditis in pre-B acute lymphoblastic leukemia with t(5;14)(q31;q32)","volume":"157","author":"George","year":"2012","journal-title":"Br. J. Haematol."},{"key":"ref_20","first-page":"166","article-title":"MDCT evaluation of cardiac involvement in hypereosinophilic syndrome","volume":"38","author":"Chen","year":"2011","journal-title":"Tex. Heart Inst. J."},{"key":"ref_21","first-page":"549","article-title":"Acute Lymphoblastic Leukemia with Eosinophilia and Strongyloides stercoralis Hyperinfection","volume":"21","author":"Nesheli","year":"2011","journal-title":"Iran. J. Pediatr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1365-2141.2010.08103.x","article-title":"Congestive heart failure as presentation of acute lymphoblastic leukemia with eosinophilia","volume":"149","author":"Nie","year":"2010","journal-title":"Br. J. Haematol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00246-008-9360-7","article-title":"A child with eosinophilia, Loffler endocarditis, and acute lymphoblastic leukemia","volume":"30","author":"Files","year":"2009","journal-title":"Pediatr. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/sj.leu.2405096","article-title":"Two cases of hypereosinophilia and high-risk acute lymphoblastic leukemia","volume":"22","author":"Sutton","year":"2008","journal-title":"Leukemia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1080\/10428190500508710","article-title":"Acute lymphoblastic leukemia with eosinophilia and unusual karyotype","volume":"47","author":"Rezk","year":"2006","journal-title":"Leuk. Lymphoma"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.leukres.2005.01.010","article-title":"Idiopathic hypereosinophilic syndrome: A case evolving in B-lymphoblastic lymphoma","volume":"29","author":"Rapanotti","year":"2005","journal-title":"Leuk. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s00380-004-0786-4","article-title":"Fatal eosinophilic heart disease in a child with neurofibromatosis-1 complicated by acute lymphoblastic leukemia","volume":"20","author":"Horigome","year":"2005","journal-title":"Heart Vessels"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/10428190500085537","article-title":"Acute lymphocytic leukemia with eosinophilia: Two case reports and a literature review","volume":"46","author":"Wilson","year":"2005","journal-title":"Leuk. Lymphoma"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1365-2141.2005.05469.x","article-title":"Hypereosinophilia in acute B-lineage lymphoblastic leukemia","volume":"129","author":"Girodon","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/cyto.b.20033","article-title":"T-Cell lymphoblastic leukemia\/lymphoma syndrome with eosinophilia and acute myeloid leukemia","volume":"65","author":"Lamb","year":"2005","journal-title":"Cytom. Part B Clin. Cytom."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1016\/j.jaad.2004.04.018","article-title":"Acute lymphoblastic leukemia presenting with urticarial plaques and hypereosinophilia in a child","volume":"51","author":"Chien","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"601","DOI":"10.5858\/2003-127-0601-MMOCFC","article-title":"Molecular monitoring of cerebrospinal fluid can predict clinical relapse in acute lymphoblastic leukemia with eosinophilia","volume":"127","author":"Zipf","year":"2003","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s10024-003-2019-8","article-title":"Acute lymphoblastic leukemia with hypereosinophilia: Report of a case with 5q deletion and review of the literature","volume":"6","author":"Wynn","year":"2003","journal-title":"Pediatr. Dev. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1525-1470.2003.20610.x","article-title":"Urticarial lesions in a child with acute lymphoblastic leukemia and eosinophilia","volume":"20","author":"Hill","year":"2003","journal-title":"Pediatr. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/clc.4950250708","article-title":"Images in cardiology: Loeffler\u2019s Endocarditis Resulting from Acute Lymphoblastic Leukemia","volume":"25","author":"Donahue","year":"2002","journal-title":"Clin. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/00043426-200205000-00019","article-title":"Vertebral compression and eosinophilia in a child with acute lymphatic leukemia","volume":"24","author":"Bjerregaard","year":"2002","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_37","first-page":"893","article-title":"Hypereosinophilia in acute lymphoblastic leukemia: An association to be remembered","volume":"86","author":"Bernasconi","year":"2001","journal-title":"Haematologica"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s002770050592","article-title":"Granular acute lymphoblastic leukemia with hypereosinophilic syndrome","volume":"79","author":"Jain","year":"2000","journal-title":"Ann. Hematol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/028418600430860","article-title":"Hyperosinophilia syndrome in acute lymphoblastic leukemia, case report and leterature review","volume":"39","author":"Narayanan","year":"2000","journal-title":"Acta Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000204396","article-title":"GM-CSF and eosinophil chemotactic factors in an acute lymphoblastic leukemia patient with eosinophilia","volume":"90","author":"Kita","year":"1993","journal-title":"Acta Haematol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/08880019209018330","article-title":"Idiopathic hypereosinophilic syndrome terminating in acute lymphoblastic leukemia","volume":"9","author":"Blatt","year":"1992","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/pgmj.67.789.702-a","article-title":"Hypereosinophilia and acute lymphoblastic leukemia","volume":"67","author":"Fernandez","year":"1991","journal-title":"Postgrad. Med. J."},{"key":"ref_43","first-page":"1861","article-title":"Mitral valvuloplasty for endomyocardial fibrosis in a child with acute leukemia and hypereosinophilia","volume":"84","author":"Dervanian","year":"1991","journal-title":"Arch. Mal. Coeur Vaiss."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000205289","article-title":"Calla-positive acute leukemia with t(5q;14q) translocation and hypereosinophilia\u2014A unique entity?","volume":"82","author":"Baumgarten","year":"1989","journal-title":"Acta Hematol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1200\/JCO.1987.5.12.2042","article-title":"Three-way reciprocal chromosomal traslocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome","volume":"5","author":"McConnell","year":"1987","journal-title":"J. Clin. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2141.1987.tb02291.x","article-title":"Abnormalities of chromosome 12p13 and malignant proliferation of eosinophils: A nonrandom association","volume":"67","author":"Keene","year":"1987","journal-title":"Br. J. Haematol."},{"key":"ref_47","first-page":"359","article-title":"Hypereosinophilia syndrome with pneumonia in acute lymphoblastic leukemia","volume":"23","author":"Tan","year":"1987","journal-title":"Aust. Pediatr. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/1097-0142(19840915)54:6<1058::AID-CNCR2820540621>3.0.CO;2-0","article-title":"The hypereosinophilic syndrome in acute lymphocytic leukemia","volume":"54","author":"Troxell","year":"1984","journal-title":"Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00043426-198423000-00019","article-title":"Exaggerated eosinophilia and acute lymphoid leukemia","volume":"6","author":"Gaynon","year":"1984","journal-title":"Am. J. Pediatr. Hematol. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0022-3476(82)80180-7","article-title":"The hypereosinophilic syndrome and lymphoblastic leukemia with extra C-group chromosome and q14+ marker","volume":"101","author":"Chilcote","year":"1982","journal-title":"J. Pediatr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00442339","article-title":"Acute lymphoblastic leukemia first appearing as hypereosinophilia","volume":"132","author":"Bottone","year":"1982","journal-title":"Eur. J. Pediatr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2141.1980.tb07174.x","article-title":"The association of eosinophilia with lymphoblastic leukemia or lymphoma: A study of seven patients","volume":"45","author":"Catovsky","year":"1980","journal-title":"Br. J. Haematol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0022-3476(78)80018-3","article-title":"Hypereosinophilia with acute lymphocytic and acute myelocytic leukemia in childhood","volume":"92","author":"Wimmer","year":"1978","journal-title":"J. Pediatr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/archinte.1978.03630260082021","article-title":"Acute lymphoblastic leukemia its occurrence with hypereosinophilic syndrome and bilateral spontaneous pneumothorax","volume":"138","author":"Geltner","year":"1978","journal-title":"Arch. Intern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1542\/peds.59.6.950","article-title":"Loffler\u2019s endomyocardial fibrosis, eosinophilia, and acute lymphoblastic leukemia","volume":"59","author":"Pereira","year":"1977","journal-title":"Pediatrics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0022-3476(76)80801-3","article-title":", 3rd. The hypereosinophilic syndrome in association with acute lymphoblastic leukemia","volume":"89","author":"Nelken","year":"1976","journal-title":"J. Pediatr."},{"key":"ref_57","first-page":"81","article-title":"Marked eosinophilia associated with acute lymphoblastic leukemia","volume":"61","author":"Rizzo","year":"1976","journal-title":"Haematologica"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.V44.4.489.489","article-title":"Loffler\u2019s andomyocardial fibrosis with eosinophilia in association with acute lymphoblastic leukemia","volume":"44","author":"Blatt","year":"1974","journal-title":"Blood"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V83.10.2759.2759","article-title":"The idiopathic hypereosinophilic syndrome","volume":"83","author":"Weller","year":"1994","journal-title":"Blood"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.7326\/0003-4819-68-6-1220","article-title":"The hyperosinophilic syndromes","volume":"68","author":"Hardy","year":"1968","journal-title":"Ann. Intern. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.leukres.2006.10.017","article-title":"Clinical significance of a blood eosinophilia in adult T-cell leukemia\/lymphoma: A blood eosinophilia is a significant unfavorable prognostic factor","volume":"31","author":"Utsunomiya","year":"2007","journal-title":"Leuk. Res."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/6\/1169\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:07:15Z","timestamp":1760195235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/6\/1169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,4]]},"references-count":61,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6]]}},"alternative-id":["ijerph15061169"],"URL":"https:\/\/doi.org\/10.3390\/ijerph15061169","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,4]]}}}