{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:44:57Z","timestamp":1787028297467,"version":"build-2736575974"},"reference-count":18,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T00:00:00Z","timestamp":1544227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology of China","award":["2016YFC1201300 & 2017YFC1200500"],"award-info":[{"award-number":["2016YFC1201300 & 2017YFC1200500"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018T110134"],"award-info":[{"award-number":["2018T110134"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Visceral leishmaniasis (VL) remains a serious public health problem in China. To explore the temporal, spatial, and spatiotemporal characteristics of visceral leishmaniasis (VL), the spatial and spatiotemporal clustering distribution and their relationships with the surrounding geographic environmental factors were analyzed. In this study, the average nearest-neighbor distance (ANN), Ripley\u2019s K-function and Moran\u2019s I statistics were used to evaluate spatial autocorrelation in the VL distribution of the existing case patterns. Getis\u2013Ord Gi* was used to identify the hot-spot and cold-spot areas based on Geographic Information System (GIS), and spatiotemporal retrospective permutation scan statistics was used to detect the spatiotemporal clusters. The results indicated that VL continues to be a serious public health problem in Kashi Prefecture, China, particularly in the north-central region of Jiashi County, which is a relatively high-risk area in which hot spots are distributed. Autumn and winter months were the outbreak season for VL cases. The detection of spatial and spatiotemporal patterns can provide epidemiologists and local governments with significant information for prevention measures and control strategies.<\/jats:p>","DOI":"10.3390\/ijerph15122784","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T03:36:41Z","timestamp":1544413001000},"page":"2784","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Spatiotemporal Variation and Hot Spot Detection of Visceral Leishmaniasis Disease in Kashi Prefecture, China"],"prefix":"10.3390","volume":"15","author":[{"given":"Canjun","family":"Zheng","sequence":"first","affiliation":[{"name":"Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resources and Environmental Information System, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Geoscience and Surveying Engineering, China University of Mining &amp; Technology (Beijing), Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-8193","authenticated-orcid":false,"given":"Gang","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Geoscience and Surveying Engineering, China University of Mining &amp; Technology (Beijing), Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4154-5969","authenticated-orcid":false,"given":"Dong","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resources and Environmental Information System, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-nong","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Institute for Parasitic Diseases, Chinese Center for Disease Control and Prevention (China CDC), Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhou, X.N., Lv, S., Yang, G.J., Kristensen, T.K., Bergquist, N.R., Utzinger, J., and Malone, J.B. (2009). Spatial Epidemiology in Zoonotic Parasitic Diseases: Insights Gained at the 1 st International Symposium on Geospatial Health in Lijiang, China, 2007, BioMed Central.","DOI":"10.1186\/1756-3305-2-10"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.parint.2010.04.002","article-title":"An outbreak of the desert sub-type of zoonotic visceral leishmaniasis in Jiashi, Xinjiang Uygur Autonomous Region, People\u2019s Republic of China","volume":"59","author":"Wang","year":"2010","journal-title":"Parasitol. Int."},{"key":"ref_3","first-page":"344","article-title":"Visceral leishmaniasis in China during 2004\u20132007","volume":"27","author":"Zheng","year":"2009","journal-title":"Chin. J. Parasitol. Parasit. Dis."},{"key":"ref_4","first-page":"291","article-title":"Recent advances in visceral leishmaniasis in China","volume":"22","author":"Guan","year":"1991","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1756-3305-5-31","article-title":"Current epidemiological profile and features of visceral leishmaniasis in people\u2019s republic of China","volume":"5","author":"Wang","year":"2012","journal-title":"Parasites Vectors"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13071-016-1430-8","article-title":"Spatial analysis of visceral leishmaniasis in the oases of the plains of Kashi Prefecture, Xinjiang Uygur Autonomous Region, China","volume":"9","author":"Wang","year":"2016","journal-title":"Parasites Vectors"},{"key":"ref_7","first-page":"431","article-title":"Epidemiological characteristics of kala-azar disease in China, during 2005\u20132015","volume":"38","author":"Zheng","year":"2017","journal-title":"Chin. J. Epidemiol."},{"key":"ref_8","first-page":"132","article-title":"A newly identified endemic area of visceral leishmaniasis in Minfeng county of south Xinjiang II. Investigation on phlebotomine vectors","volume":"26","author":"Jin","year":"2008","journal-title":"J. Parasitol. Parasit. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/S0140-6736(08)61365-3","article-title":"Emergence and control of infectious diseases in China","volume":"372","author":"Wang","year":"2008","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/zph.12109","article-title":"Geographic information system-based analysis of the spatial and spatio-temporal distribution of zoonotic cutaneous leishmaniasis in Golestan Province, north-east of Iran","volume":"62","author":"Mollalo","year":"2015","journal-title":"Zoonoses Public Health"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bruschi, F., and Gradoni, L. (2018). A brief introduction to leishmaniasis epidemiology. The Leishmaniases: Old Neglected Tropical Diseases, Springer.","DOI":"10.1007\/978-3-319-72386-0"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Bhunia, G.S., Kesari, S., Chatterjee, N., Kumar, V., and Das, P. (2013). Spatial and temporal variation and hotspot detection of kala-azar disease in Vaishali district (Bihar), India. BMC Infect. Dis., 13.","DOI":"10.1186\/1471-2334-13-64"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kulldorff, M., Heffernan, R., Hartman, J., Assun\u00e7ao, R., and Mostashari, F. (2005). A space\u2013time permutation scan statistic for disease outbreak detection. PLoS Med., 2.","DOI":"10.1371\/journal.pmed.0020059"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.apjtb.2017.09.011","article-title":"Spatiotemporal clustering of cutaneous leishmaniasis in Fars province, Iran","volume":"7","author":"Zare","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1590\/0074-02760160074","article-title":"Spatial modeling of cutaneous leishmaniasis in the Andean region of Colombia","volume":"111","author":"Ocampo","year":"2016","journal-title":"Mem\u00f3rias Do Inst. Oswaldo Cruz"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4269\/ajtmh.2003.68.1.0680010","article-title":"Risk mapping of visceral leishmaniasis: The role of local variation in rainfall and altitude on the presence and incidence of kala-azar in eastern Sudan","volume":"68","author":"Elnaiem","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1179\/136485910X12607012373678","article-title":"The use of remote sensing in the identification of the eco-environmental factors associated with the risk of human visceral leishmaniasis (kala-azar) on the Gangetic plain, in north\u2013eastern India","volume":"104","author":"Bhunia","year":"2010","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_18","unstructured":"Fu, Q. (2007). Time-Space Clustering Analysis and Vector\u2019s Distribution of Anthroponotic Kala-azar in Kashi Region of Xinjiang. [Master\u2019s Thesis, Chinese Center for Disease Control and Prevention (CDC)]. (In Chinese)."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/12\/2784\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:32:13Z","timestamp":1760196733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/15\/12\/2784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,8]]},"references-count":18,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["ijerph15122784"],"URL":"https:\/\/doi.org\/10.3390\/ijerph15122784","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,8]]}}}