{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:39:19Z","timestamp":1775320759221,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The present study aimed to investigate the relationship between the occurrence of ventilator-associated events (VAE) in the intensive care unit and the timing of rehabilitation intervention. We included subjects who underwent emergency tracheal intubation and received rehabilitation. We performed rehabilitation according to our hospital\u2019s protocol. We assessed the mechanical ventilation parameters of inspired oxygen fraction and positive-end expiratory pressure, and a VAE was identified if these parameters stabilized or decreased for \u22652 days and then had to be increased for \u22652 days. We defined time in hours from tracheal intubation to the first rehabilitation intervention as Timing 1 and that to first sitting on the edge of the bed as Timing 2. Data were analyzed by the t-test and \u03c72 tests. We finally analyzed 294 subjects. VAE occurred in 9.9% and high mortality at 48.3%. Median values of Timing 1 and Timing 2 in the non-VAE and VAE groups were 30.3 \u00b1 24.0 and 30.0 \u00b1 20.7 h, and 125.7 \u00b1 136.6 and 127.9 \u00b1 111.4 h, respectively, and the differences were not significant (p = 0.95 and p = 0.93, respectively). We found no significant relationship between the occurrence of VAE leading to high mortality and timing of rehabilitation intervention.<\/jats:p>","DOI":"10.3390\/ijerph15122892","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T02:15:59Z","timestamp":1545099359000},"page":"2892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between Ventilator-Associated Events and Timing of Rehabilitation in Subjects with Emergency Tracheal Intubation at Early Mobilization Facility"],"prefix":"10.3390","volume":"15","author":[{"given":"Taku","family":"Shinoda","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Division of Physical Therapy, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan"},{"name":"Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP), Kobe 654-0142, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Division of Physical Therapy, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Shimogai","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Division of Physical Therapy, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan"},{"name":"Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP), Kobe 654-0142, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsubasa","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Division of Physical Therapy, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuya","family":"Takimoto","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Division of Physical Therapy, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9190-2434","authenticated-orcid":false,"given":"Ryutaro","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP), Kobe 654-0142, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7262-8903","authenticated-orcid":false,"given":"Kazuhiro P.","family":"Izawa","sequence":"additional","affiliation":[{"name":"Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP), Kobe 654-0142, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Division of Physical Therapy, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s00134-006-0517-7","article-title":"Epidemiology of sepsis in Germany: Results from a national prospective multicenter study","volume":"33","author":"Engel","year":"2007","journal-title":"Intensive Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/cc7100","article-title":"Clinical review: Critical illness polyneuropathy and myopathy","volume":"12","author":"Hermans","year":"2008","journal-title":"Crit. 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