{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:38:55Z","timestamp":1790883535867,"version":"4.1.0"},"reference-count":25,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Sub-optimal chronic obstructive pulmonary disease (COPD) management has been found largely due to patients\u2019 medication non-adherence and incorrect inhaler technique. This study aimed to examine inhaler use technique and medication adherence among Vietnamese COPD patients as well as potential associated factors. A cross-sectional study involving 70 COPD exacerbators was conducted. Inhaler technique and adherence were evaluated by the 10-item and 12-item Test of Adherence to Inhaler (TAI). Data on the history of COPD, home prescription of inhalers and duration of hospitalization were also collected. Generalized linear regression models were used to determine the associated factors with inhaler use and medication adherence. The results showed that the proportion of patients with good inhaler technique was 22.7% for metered-dose inhalers (MDI), 30.4% for dry powder inhalers (DPI) and 31.8% for soft-mist inhalers (SMI). Full exhalation was the most common mistake. The rates of non-compliance patterns were: \u201cignorant\u201d (77.1%), \u201csporadic\u201d (58.6%), and \u201cdeliberate\u201d (55.7%). Worse dyspnea, greater health condition impairment, and an increased frequency of exacerbations and hospitalizations were found to be associated negatively with correct inhaler use and treatment adherence. Instructions to COPD patients about using inhalers should focus on correct inhaler technique and adherence even when feeling healthy.<\/jats:p>","DOI":"10.3390\/ijerph16020185","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T04:10:16Z","timestamp":1547179816000},"page":"185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Inhaler Technique and Adherence to Inhaled Medications among Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Vietnam"],"prefix":"10.3390","volume":"16","author":[{"given":"Chau Quy","family":"Ngo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hanoi Medical University, Hanoi 100000, Vietnam"},{"name":"Respiratory Center, Bach Mai Hospital, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dung Minh","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanoi Medical University, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giap Van","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanoi Medical University, Hanoi 100000, Vietnam"},{"name":"Respiratory Center, Bach Mai Hospital, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phu Ngoc","family":"Dao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanoi Medical University, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong Thu","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanoi Medical University, Hanoi 100000, Vietnam"},{"name":"Respiratory Center, Bach Mai Hospital, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanh Thi","family":"Chu","sequence":"additional","affiliation":[{"name":"Respiratory Center, Bach Mai Hospital, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long Hoang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center of Excellence in Behavioral Medicine, Nguyen Tat Thanh University, Ho Chi Minh City 70000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giang Thu","family":"Vu","sequence":"additional","affiliation":[{"name":"Center of Excellence in Evidence-Based Medicine, Nguyen Tat Thanh University, Ho Chi Minh City 70000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giang Hai","family":"Ha","sequence":"additional","affiliation":[{"name":"Institute for Global Health Innovations, Duy Tan University, Da Nang 55000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung Hoang","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Lower Limb Surgery, Vietnam-Germany Hospital, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-8449","authenticated-orcid":false,"given":"Bach Xuan","family":"Tran","sequence":"additional","affiliation":[{"name":"Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam"},{"name":"Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7931-2116","authenticated-orcid":false,"given":"Carl A.","family":"Latkin","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-9566","authenticated-orcid":false,"given":"Cyrus S. H.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, National University Hospital, Singapore 119074, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9629-4493","authenticated-orcid":false,"given":"Roger C. M.","family":"Ho","sequence":"additional","affiliation":[{"name":"Center of Excellence in Behavioral Medicine, Nguyen Tat Thanh University, Ho Chi Minh City 70000, Vietnam"},{"name":"Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2018, December 01). Chronic Respiratory Diseases\u2014Burden of COPD. Available online: http:\/\/www.who.int\/respiratory\/copd\/burden\/en\/."},{"key":"ref_2","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (2018, December 01). Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: 2019 Report. Available online: https:\/\/goldcopd.org\/wp-content\/uploads\/2018\/11\/GOLD-2019-v1.7-FINAL-14Nov2018-WMS.pdf."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mathers, C.D., and Loncar, D. (2006). Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med., 3.","DOI":"10.1371\/journal.pmed.0030442"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/jamp.2014.1142","article-title":"Inhaler devices for chronic obstructive pulmonary disease: Insights from patients and healthcare practitioners","volume":"28","author":"Molimard","year":"2015","journal-title":"J. Aerosol. Med. Pulm. Drug Deliv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1177\/1715163516660573","article-title":"Inhaler assessment in COPD patients: A primer for pharmacists","volume":"149","author":"Dougall","year":"2016","journal-title":"Can. Pharm. J. (Ott)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2147\/COPD.S149404","article-title":"Factors associated with appropriate inhaler use in patients with COPD\u2014Lessons from the REAL survey","volume":"13","author":"Price","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulm. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2147\/COPD.S32674","article-title":"Practical aspects of inhaler use in the management of chronic obstructive pulmonary disease in the primary care setting","volume":"7","author":"Yawn","year":"2012","journal-title":"Int. J. Chron. Obstruct. Pulm. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.1440-1843.2003.00460.x","article-title":"COPD prevalence in 12 Asia-Pacific countries and regions: Projections based on the COPD prevalence estimation model","volume":"8","author":"Regional","year":"2003","journal-title":"Respirology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12930-015-0020-9","article-title":"Impact of chronic obstructive pulmonary disease (COPD) in the Asia-Pacific region: The EPIC Asia population-based survey","volume":"14","author":"Lim","year":"2015","journal-title":"Asia Pac. Fam. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1089\/jamp.2015.1212","article-title":"Validation of the \u2018Test of the Adherence to Inhalers\u2019(TAI) for Asthma and COPD Patients","volume":"29","author":"Plaza","year":"2016","journal-title":"J. Aerosol. Med. Pulm. Drug Deliv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.rmed.2014.04.021","article-title":"Evaluating the technique of using inhalation device in COPD and bronchial asthma patients","volume":"108","author":"Arora","year":"2014","journal-title":"Respir. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.rmed.2014.04.019","article-title":"Inhaler devices in asthma and COPD\u2014An assessment of inhaler technique and patient preferences","volume":"108","author":"Chorao","year":"2014","journal-title":"Respir. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/1479972315606313","article-title":"Suboptimal inhaler medication adherence and incorrect technique are common among chronic obstructive pulmonary disease patients","volume":"13","author":"Sriram","year":"2016","journal-title":"Chron. Respir. Dis."},{"key":"ref_14","first-page":"111","article-title":"Evaluation of the use of inhaled medications by hospital inpatients with chronic obstructive pulmonary disease","volume":"65","author":"Batterink","year":"2012","journal-title":"Can. J. Hosp. Pharm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.rmed.2007.06.008","article-title":"Can all patients with COPD use the correct inhalation flow with all inhalers and does training help?","volume":"101","author":"Tarsin","year":"2007","journal-title":"Respir. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1378\/chest.128.5.3198","article-title":"Factors associated with medication nonadherence in patients with COPD","volume":"128","author":"George","year":"2005","journal-title":"Chest"},{"key":"ref_17","first-page":"328","article-title":"Factors associated with medication adherence in patients with chronic obstructive pulmonary disease","volume":"82","author":"Agh","year":"2011","journal-title":"Respir. Int. Rev. Thorac. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Montes de Oca, M., Menezes, A., Wehrmeister, F.C., Lopez Varela, M.V., Casas, A., Ugalde, L., Ramirez-Venegas, A., Mendoza, L., L\u00f3pez, A., and Surmont, F. (2017). Adherence to inhaled therapies of COPD patients from seven Latin American countries: The LASSYC study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186777"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3109\/15412555.2015.1118449","article-title":"Differences in adherence and non-adherence behaviour patterns to inhaler devices between COPD and asthma patients","volume":"13","author":"Plaza","year":"2016","journal-title":"COPD J. Chron. Obstruct. Pulm. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/2049-6958-9-60","article-title":"COPD: Adherence to therapy","volume":"9","author":"Sanduzzi","year":"2014","journal-title":"Multidiscip. Respir. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.rmed.2011.01.005","article-title":"Inhaler mishandling remains common in real life and is associated with reduced disease control","volume":"105","author":"Melani","year":"2011","journal-title":"Respir. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1590\/S1806-37132014000100003","article-title":"Factors related to the incorrect use of inhalers by asthma patients","volume":"40","author":"Grutcki","year":"2014","journal-title":"J. Bras. Pneumol."},{"key":"ref_23","first-page":"59","article-title":"The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes","volume":"12","author":"Chrystyn","year":"2017","journal-title":"Int. J. Chron. Obstruct. Pulm. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2165\/00002512-200421120-00004","article-title":"Medication non-adherence in the elderly: How big is the problem?","volume":"21","author":"Hughes","year":"2004","journal-title":"Drugs Aging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2147\/COPD.S85681","article-title":"Evaluating inhaler use technique in COPD patients","volume":"10","author":"Pothirat","year":"2015","journal-title":"Int. J. Chron. Obstruct. Pulm. Dis."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/2\/185\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:24:57Z","timestamp":1760185497000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/2\/185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,1]]}},"alternative-id":["ijerph16020185"],"URL":"https:\/\/doi.org\/10.3390\/ijerph16020185","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,10]]}}}