{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:23:49Z","timestamp":1782401029934,"version":"3.54.5"},"reference-count":27,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Purpose: Dry eye syndrome (DES) is a common disease with an increasing occurrence. Although DES symptoms are considered mild, it can reduce quality of life for individuals. Many studies on DES have been conducted, but these focused on the use of electronic devices. Here, we investigate an association between DES and sleep disorders in the context of emerging health issues. Methods: Our data came from the National Health Insurance Service (NHIS) National Sample Cohort, which included 44,366 patients and was based on a 1:1 matching method (sleep disorder patients vs. patients without sleep disorders) during 2012\u20132015. Using survival analysis with a Cox proportional hazard model, we identified an association of sleep disorders with DES. Results: About 16.7% of all patients were diagnosed with DES, and prevalence was higher in patients with sleep disorders (sleep disorders: 19.82%, no sleep disorders: 13.67%). Survival analysis showed that sleep disorders positively correlated with DES diagnosis (Hazard Ratio (HR): 1.320, 95% Confidence Interval (CI): 1.261\u20131.382, p-value &lt; 0.0001). Positive trends were enhanced in males, younger patients, lower economic levels, and with higher severity of comorbid. Conclusions: Our findings suggest that sleep disorder was positively associated with DES. This correlation can be helpful in effective management of both sleep disorders and DES in South Koreans.<\/jats:p>","DOI":"10.3390\/ijerph16050878","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T03:49:31Z","timestamp":1552362571000},"page":"878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Do Sleep Disorders Positively Correlate with Dry Eye Syndrome? Results of National Claim Data"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5817-1203","authenticated-orcid":false,"given":"Kyu-Tae","family":"Han","sequence":"first","affiliation":[{"name":"Division of Cancer Control and Policy, National Cancer Center, Goyang 10408, Korea"},{"name":"Institute of Health Services Research, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-7581","authenticated-orcid":false,"given":"Ji","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang 10326, Korea"},{"name":"Department of Medicine, Graduate School, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-5398","authenticated-orcid":false,"given":"Eun-Cheol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.asieco.2006.06.007","article-title":"The role of financial development in economic growth: The experiences of Taiwan, Korea, and Japan","volume":"17","author":"Liu","year":"2006","journal-title":"J. Asian Econ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/heapol\/czn037","article-title":"Thirty years of national health insurance in South Korea: Lessons for achieving universal health care coverage","volume":"24","author":"Kwon","year":"2008","journal-title":"Health Policy Plan."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0165-1781(98)00122-X","article-title":"Prevalence of symptoms of depression in a nationwide sample of Korean adults","volume":"81","author":"Cho","year":"1998","journal-title":"Psychiatry Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF02599573","article-title":"Sleep problems and their correlates in a working population","volume":"10","author":"Kuppermann","year":"1995","journal-title":"J. Gen. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.psychres.2016.08.047","article-title":"Sleep disorders and risk of hospitalization in patients with mood disorders: Analysis of the National Sample Cohort over 10 years","volume":"245","author":"Han","year":"2016","journal-title":"Psychiatry Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.psychres.2017.11.076","article-title":"Association between sleep disorder and panic disorder in South Korea: Nationwide nested case-control study of data from 2004 to 2013","volume":"260","author":"Park","year":"2018","journal-title":"Psychiatry Res."},{"key":"ref_7","unstructured":"National Health Insurance Service (2018). Statistics for Diseases: Sleep Disorder, National Health Insurance Service."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.smrv.2009.10.004","article-title":"The influence of sleep quality, sleep duration and sleepiness on school performance in children and adolescents: A meta-analytic review","volume":"14","author":"Dewald","year":"2010","journal-title":"Sleep Med. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ypmed.2009.06.016","article-title":"Sleep duration, sleep quality and cardiovascular disease mortality among the elderly: A population-based cohort study","volume":"49","author":"Suzuki","year":"2009","journal-title":"Prev. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1001\/archinte.166.16.1768","article-title":"Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus","volume":"166","author":"Knutson","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_11","unstructured":"National Health Insurance Service (2018). Statistics for Diseases: Dry Eye Syndrome, National Health Insurance Service."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.12799\/jkachn.2014.25.1.12","article-title":"Influence of cellular phone videos and games on dry eye syndrome in university students","volume":"25","author":"Park","year":"2014","journal-title":"J. Korean Acad. Community Health Nurs."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.survophthal.2005.02.008","article-title":"Computer vision syndrome: A review","volume":"50","author":"Blehm","year":"2005","journal-title":"Surv. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ajo.2006.11.060","article-title":"Impact of dry eye syndrome on vision-related quality of life","volume":"143","author":"Dana","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e629","DOI":"10.1097\/PR9.0000000000000629","article-title":"Evidence that dry eye is a comorbid pain condition in a US veteran population","volume":"2","author":"Lee","year":"2017","journal-title":"Pain Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22480","DOI":"10.1038\/srep22480","article-title":"Sleep and mood disorders in dry eye disease and allied irritating ocular diseases","volume":"6","author":"Ayaki","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2147\/NDT.S81515","article-title":"High prevalence of sleep and mood disorders in dry eye patients: Survey of 1,000 eye clinic visitors","volume":"11","author":"Ayaki","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson","year":"1994","journal-title":"J. Clin. Epidemiol."},{"key":"ref_19","unstructured":"Organization for Economic Co-operation and Development (OECD) (2009). Society at a Glance 2009, in OECD Social Indicators, OECD Publishing."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1097\/ICL.0000000000000349","article-title":"The association of dry eye symptom severity and comorbid insomnia in US veterans","volume":"44","author":"Galor","year":"2018","journal-title":"Eye Contact Lens"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1001\/jamaophthalmol.2016.4925","article-title":"Longitudinal examination of frequency of and risk factors for severe dry eye symptoms in US veterans","volume":"135","author":"Ong","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"DES143","DOI":"10.1167\/iovs.17-23467","article-title":"Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye","volume":"59","author":"Ayaki","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.sleep.2015.06.021","article-title":"The association between sleep duration and dry eye syndrome among Korean adults","volume":"16","author":"Lee","year":"2015","journal-title":"Sleep Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1167\/iovs.14-13881","article-title":"Sleep Deprivation Reduces Tear Secretion and Impairs the Tear FilmSleep Deprivation Effect on Tear Secretion and Tear Film","volume":"55","author":"Lee","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1001\/archopht.118.9.1264","article-title":"Prevalence of and risk factors for dry eye syndrome","volume":"118","author":"Moss","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"ref_26","first-page":"1051","article-title":"Group prenatal care and preterm birth weight: Results from a matched cohort study at public clinics","volume":"102","author":"Ickovics","year":"2003","journal-title":"Obstet. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1001\/jama.1997.03550240060035","article-title":"Benzodiazepines and zolpidem for chronic insomnia: A meta-analysis of treatment efficacy","volume":"278","author":"Nowell","year":"1997","journal-title":"JAMA"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/5\/878\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:37:45Z","timestamp":1760186265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/5\/878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,11]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["ijerph16050878"],"URL":"https:\/\/doi.org\/10.3390\/ijerph16050878","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,11]]}}}