{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:58:21Z","timestamp":1785538701742,"version":"3.56.0"},"reference-count":20,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["5P30ES000260"],"award-info":[{"award-number":["5P30ES000260"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200 \u2013 2017 - 93327"],"award-info":[{"award-number":["200 \u2013 2017 - 93327"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200 \u2013 2017 - 93427"],"award-info":[{"award-number":["200 \u2013 2017 - 93427"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Sarcoidosis is a granulomatous disease involving intrathoracic and extrathoracic organs. Genetic and environmental factors, such as exposure to World-Trade Center (WTC) dust after 9\/11, may play a role in clinical presentation. Characterization of sarcoidosis in community members with exposure to the WTC dust can provide further insight into the relationship between environmental exposure and sarcoidosis. Methods: Patients with documented sarcoidosis were identified in the WTC Environmental Health Center (EHC), a treatment program for community members. Demographic and clinical data were collected from standardized questionnaires and chart review. Organ involvement was assessed with a standard instrument. Results: Among patients in the WTC EHC, 87 were identified with sarcoidosis after 9\/11. Sarcoidosis cases were more likely African-American, local workers, and had more respiratory symptoms, compared with non-sarcoidosis WTC EHC patients. Many (46%) had \u2265 Scadding stage 3 on chest imaging, and had reduced lung function measures. Extrathoracic involvement was identified in 33\/87 (38%) with a diversity of organs involved. Conclusions: WTC-exposed sarcoidosis in community members is often characterized by severe pulmonary disease and a high rate of diverse extrathoracic involvement. Further analysis is required to characterize the course of disease progression or resolution.<\/jats:p>","DOI":"10.3390\/ijerph16071291","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T03:46:37Z","timestamp":1555040797000},"page":"1291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure"],"prefix":"10.3390","volume":"16","author":[{"given":"Kerry M.","family":"Hena","sequence":"first","affiliation":[{"name":"Department of Medicine, New York University, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scarlett","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Population Health and Environmental Medicine, New York University, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhao","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Population Health and Environmental Medicine, New York University, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Kazeros","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Reibman","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University, New York, NY 10016, USA"},{"name":"Department of Population Health and Environmental Medicine, New York University, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(13)60680-7","article-title":"Sarcoidosis","volume":"383","author":"Valeyre","year":"2014","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1378\/chest.06-2114","article-title":"World Trade Center \u201cSarcoid-Like\u201d Granulomatous Pulmonary Disease in New York City Fire Department Rescue Workers","volume":"131","author":"Izbicki","year":"2007","journal-title":"Chest"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/ajim.20924","article-title":"\u201cSarcoid like\u201d granulomatous pulmonary disease in World Trade Center disaster responders","volume":"54","author":"Crowley","year":"2010","journal-title":"Am. 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