{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:02:09Z","timestamp":1790359329118,"version":"4.1.0"},"reference-count":86,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Exposure to endocrine disruptors is on the rise, with new compounds regularly incriminated. In animals and humans, this exposure during critical developmental windows has been associated with various developmental abnormalities, including the emergence of psychiatric disorders. We aimed to review the association between perinatal endocrine disruptor exposure and neurodevelopmental disorders in humans, focusing on cognitive and psychiatric disorders. Methods: We performed a systematic review with key words referring to the fields of neurodevelopment and endocrine disruptors. We reviewed 896 titles, choosing studies on the basis of titles and abstracts. We searched through the methodology sections to find perinatal exposure and neurodevelopmental disorders, following the categories indicated in the Diagnostic and Statistic Manual of Mental Disorders (5th edition). References in some studies brought us to a total of 47 studies included here. Results: Convergent studies report an association between exposure to endocrine disruptors and autism spectrum disorder, attention-deficit hyperactivity disorder, global developmental delay, intellectual disability, communication disorders and unspecified neurodevelopmental disorders. Conclusion: Sufficient data exist to report that exposure to some endocrine disruptors is a risk factor for the emergence of neurodevelopmental disorders. Studying endocrine disruptor exposure in humans is still associated with some limits that are difficult to overcome.<\/jats:p>","DOI":"10.3390\/ijerph16081318","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T12:55:04Z","timestamp":1555073704000},"page":"1318","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Perinatal Exposure to Environmental Endocrine Disruptors in the Emergence of Neurodevelopmental Psychiatric Diseases: A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"given":"Fabrice","family":"Rivollier","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM), Physiopathologie des Maladies Psychiatriques, Inserm 1266 Institut de Psychiatrie et Neurosciences de Paris (IPNP), 75014 Paris, France"},{"name":"Centre National de la Recherche Scientifique (CNRS), Institut de Psychiatrie, GDR 3557, 75014 Paris, France"},{"name":"GHU Paris, Sainte-Anne, Service Hospitalo-Universitaire, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Krebs","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM), Physiopathologie des Maladies Psychiatriques, Inserm 1266 Institut de Psychiatrie et Neurosciences de Paris (IPNP), 75014 Paris, France"},{"name":"Centre National de la Recherche Scientifique (CNRS), Institut de Psychiatrie, GDR 3557, 75014 Paris, France"},{"name":"GHU Paris, Sainte-Anne, Service Hospitalo-Universitaire, 75014 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine Paris Descartes, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3233-094X","authenticated-orcid":false,"given":"Oussama","family":"Kebir","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM), Physiopathologie des Maladies Psychiatriques, Inserm 1266 Institut de Psychiatrie et Neurosciences de Paris (IPNP), 75014 Paris, France"},{"name":"Centre National de la Recherche Scientifique (CNRS), Institut de Psychiatrie, GDR 3557, 75014 Paris, France"},{"name":"GHU Paris, Sainte-Anne, Service d\u2019Addictologie \u00abMoreau de Tours\u00bb, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"ref_1","first-page":"807","article-title":"Statement from the work session on chemically-induced alterations in the developing immune system: The wildlife\/human connection","volume":"104","author":"Colborn","year":"1996","journal-title":"Environ. 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