{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:33:19Z","timestamp":1782487999697,"version":"3.54.5"},"reference-count":40,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This study investigated the association of statin use with sepsis risk in patients with dementia. This retrospective cohort study was conducted in Taiwan by using data from the National Health Insurance Research Database. We identified and enrolled 308 patients with newly diagnosed dementia who used statin after dementia diagnosis. These patients were individually propensity score matched (1:1) according to age, sex, hypertension, hyperlipidemia, diabetes, cerebrovascular disease, renal disease, liver disease, asthma, malignancy, parkinsonism, and dementia drugs used (donepezil, rivastigmine, galantamine, and memantine) with 251 controls (statin non-users). A Cox proportional hazard model was used to estimate the adjusted hazard ratio for sepsis in statin users and non-users. After adjustment for other confounding factors, the incidence of sepsis in statin users was 1.42-fold higher than that in non-users (95% confidence interval = 0.81\u20132.5). In conclusion, our analysis showed no positive association of sepsis with statin use in patients with dementia.<\/jats:p>","DOI":"10.3390\/ijerph16091626","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T11:22:35Z","timestamp":1557400955000},"page":"1626","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3485-6937","authenticated-orcid":false,"given":"Liang-Tsai","family":"Yeh","sequence":"first","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"},{"name":"Department of Anesthesiology, Changhua Christian Hospital, Changhua 500, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Information Engineering, Providence University, Taichung City 433, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-7927","authenticated-orcid":false,"given":"Shun-Fa","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"},{"name":"Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Wei","family":"Yeh","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Tung","family":"Yeh","sequence":"additional","affiliation":[{"name":"Graduate School of Dentistry, Chung Shan Medical University, Taichung 402, Taiwan"},{"name":"School of Dentistry, Chung Shan Medical University, Taichung 402, Taiwan"},{"name":"Department of Dentistry, Chung Shan Medical University Hospital, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chih","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3978-5576","authenticated-orcid":false,"given":"Chao-Bin","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"},{"name":"Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"},{"name":"Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Ho","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan"},{"name":"Department of Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.phrs.2014.03.002","article-title":"The pharmacology of statins","volume":"88","author":"Sirtori","year":"2014","journal-title":"Pharmacol. Res."},{"key":"ref_2","first-page":"95","article-title":"Statins for primary and secondary prevention of coronary heart disease. A scientific review","volume":"23","author":"Carneiro","year":"2004","journal-title":"Revista portuguesa de cardiologia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/bmj.38992.565972.7C","article-title":"Statins and outcomes in patients admitted to hospital with community acquired pneumonia: Population based prospective cohort study","volume":"333","author":"Majumdar","year":"2006","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.7861\/clinmedicine.17-5-403","article-title":"Statin therapy in patients with community-acquired pneumonia","volume":"17","author":"Grudzinska","year":"2017","journal-title":"Clin. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mohammad, S., Nguyen, H., Nguyen, M., Abdel-Rasoul, M., Nguyen, V., Nguyen, C.D., Nguyen, K.T., Li, L., and Kitzmiller, J.P. (2018). Pleotropic effects of statins: Untapped potential for statin pharmacotherapy. Curr. Vasc. Pharmacol.","DOI":"10.2174\/1570161116666180723120608"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/CIRCULATIONAHA.112.136101","article-title":"Effect of statins on skeletal muscle function","volume":"127","author":"Parker","year":"2013","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2174\/1381612820666141013134447","article-title":"Adverse effects of statins-myths and reality","volume":"21","author":"Simic","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1517\/14740338.2015.1096343","article-title":"Statins and their increased risk of inducing diabetes","volume":"14","author":"Agouridis","year":"2015","journal-title":"Exp. Opin. Drug Saf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ccl.2015.02.004","article-title":"Statins and diabetes","volume":"33","author":"Maki","year":"2015","journal-title":"Cardiol. Clin."},{"key":"ref_10","first-page":"254","article-title":"Hepatotoxicity associated with statins","volume":"68","author":"Karahalil","year":"2017","journal-title":"Arch. Ind. Hyg. Toxicol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/14740338.2018.1394455","article-title":"Statin drug interactions and related adverse reactions: An update","volume":"17","author":"Bellosta","year":"2018","journal-title":"Exp. Opin. Drug Saf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phrs.2014.06.007","article-title":"Statins in neurological disorders: An overview and update","volume":"88","author":"Malfitano","year":"2014","journal-title":"Pharmacol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.18865\/ed.25.3.345","article-title":"Statin use, incident dementia and alzheimer disease in elderly african americans","volume":"25","author":"Hendrie","year":"2015","journal-title":"Ethn. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pnpbp.2015.11.013","article-title":"Statins and the brain: New perspective for old drugs","volume":"66","author":"Ling","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2165\/0129784-200808060-00004","article-title":"Statin adverse effects: A review of the literature and evidence for a mitochondrial mechanism","volume":"8","author":"Golomb","year":"2008","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2146\/ajhp100700","article-title":"Strategies to preserve the use of statins in patients with previous muscular adverse effects","volume":"69","author":"Reinhart","year":"2012","journal-title":"Am. J. Health-Syst. Pharm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pharmthera.2018.10.004","article-title":"Statins: Adverse reactions, oxidative stress and metabolic interactions","volume":"195","author":"Liu","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4046\/trd.2018.0041","article-title":"Sepsis: Early recognition and optimized treatment","volume":"82","author":"Kim","year":"2019","journal-title":"Tuberc. Respir. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/jama.2016.0290","article-title":"New definitions for sepsis and septic shock: Continuing evolution but with much still to be done","volume":"315","author":"Abraham","year":"2016","journal-title":"JAMA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/ije\/dyy007","article-title":"Prevalence of dementia in mainland china, Hong Kong and Taiwan: An updated systematic review and meta-analysis","volume":"47","author":"Wu","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"656.e7","DOI":"10.1016\/j.jcrc.2010.02.013","article-title":"The effect of statins on mortality from severe infections and sepsis: A systematic review and meta-analysis","volume":"25","author":"Janda","year":"2010","journal-title":"J. Crit. Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/jac\/dkn019","article-title":"Statins for infection and sepsis: A systematic review of the clinical evidence","volume":"61","author":"Falagas","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/01.CIR.0000138932.17956.F1","article-title":"Prior statin therapy is associated with a decreased rate of severe sepsis","volume":"110","author":"Almog","year":"2004","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCULATIONAHA.104.502195","article-title":"Statin treatment after onset of sepsis in a murine model improves survival","volume":"112","author":"Merx","year":"2005","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1210\/jc.2014-4463","article-title":"Statins may increase the risk of liver dysfunction in patients treated with steroids for active graves\u2019 orbitopathy","volume":"100","author":"Covelli","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"d7134","DOI":"10.1136\/bmj.d7134","article-title":"Do statins reduce the risk of infection?","volume":"343","author":"Golomb","year":"2011","journal-title":"BMJ"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"d7281","DOI":"10.1136\/bmj.d7281","article-title":"Statins and prevention of infections: Systematic review and meta-analysis of data from large randomised placebo controlled trials","volume":"343","author":"Bos","year":"2011","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(06)68041-0","article-title":"Statins and sepsis in patients with cardiovascular disease: A population-based cohort analysis","volume":"367","author":"Hackam","year":"2006","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/bja\/aex294","article-title":"Preadmission statin use improves the outcome of less severe sepsis patients\u2014A population-based propensity score matched cohort study","volume":"119","author":"Lee","year":"2017","journal-title":"Br. J. Anaesth."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/sj.ki.5000300","article-title":"Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects","volume":"69","author":"Yasuda","year":"2006","journal-title":"Kidney Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.biopha.2017.07.105","article-title":"An experimental study of the protective effect of simvastatin on sepsis-induced myocardial depression in rats","volume":"94","author":"Wang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1164\/rccm.201209-1718OC","article-title":"A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis","volume":"187","author":"Kruger","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e11578","DOI":"10.1097\/MD.0000000000011578","article-title":"The effects of statin therapy on mortality in patients with sepsis: A meta-analysis of randomized trials","volume":"97","author":"Chen","year":"2018","journal-title":"Medicine"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0002-9343(00)00353-3","article-title":"Effects of lovastatin on cognitive function and psychological well-being","volume":"108","author":"Muldoon","year":"2000","journal-title":"Am. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.amjmed.2004.07.041","article-title":"Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults","volume":"117","author":"Muldoon","year":"2004","journal-title":"Am. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1378\/chest.124.3.1016","article-title":"Cirrhosis as a risk factor for sepsis and death: Analysis of the national hospital discharge survey","volume":"124","author":"Foreman","year":"2003","journal-title":"Chest"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ki.2008.346","article-title":"Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome","volume":"74","author":"Doi","year":"2008","journal-title":"Kidney Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.12659\/MSM.903144","article-title":"Association between diabetes mellitus and outcomes of patients with sepsis: A meta-analysis","volume":"23","author":"Wang","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bermejo-Martin, J.F., Martin-Fernandez, M., Lopez-Mestanza, C., Duque, P., and Almansa, R. (2018). Shared features of endothelial dysfunction between sepsis and its preceding risk factors (aging and chronic disease). J. Clin. Med., 7.","DOI":"10.3390\/jcm7110400"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/9\/1626\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:50:34Z","timestamp":1760187034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/9\/1626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["ijerph16091626"],"URL":"https:\/\/doi.org\/10.3390\/ijerph16091626","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]}}}