{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:09:39Z","timestamp":1788959379381,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Sickle cell anaemia is one of the most common hemoglobinopathies worldwide and an important public health problem in Brazil. This study evaluated the prevalence of sickle cell anaemia and its traits in newborns from the Amazon-Savanna Transition Region in the state of Maranh\u00e3o, Brazil. A cross-sectional study was carried out, based on data from neonatal screening tests performed in 2013\u20132015 in Maranh\u00e3o. The Hardy-Weinberg theorem was applied to analyse the frequency of expected homozygotes based on HbSS phenotype. A spatial-temporal distribution analysis was performed to delimit the regions with the greatest number of newborn cases with sickle cell anaemia. Of 283,003 newborns, 162 were found to have sickle cell anaemia, while 10,794 had a sickle cell trait, with a prevalence of 0.05% and 3.8%, respectively. The prevalence of expected homozygotes was higher in the North Region and in the state capital of Maranh\u00e3o. This study may contribute to existing social and public health actions or the creation of new strategies for sickle cell disease in endemic areas in Brazil to improve the quality of life.<\/jats:p>","DOI":"10.3390\/ijerph16091638","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T03:57:07Z","timestamp":1557719827000},"page":"1638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sickle Cell Anaemia Prevalence among Newborns in the Brazilian Amazon-Savanna Transition Region"],"prefix":"10.3390","volume":"16","author":[{"given":"Rayane Cristina","family":"Souza","sequence":"first","affiliation":[{"name":"Biom\u00e9dica and Mestranda em Meio Ambiente da Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-9098","authenticated-orcid":false,"given":"Pedro Agnel Dias","family":"Miranda Neto","sequence":"additional","affiliation":[{"name":"Faculdade Pit\u00e1goras, S\u00e3o Lu\u00eds 65075-120, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessflan Rafael Nascimento","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Geotecnologias, Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-4577","authenticated-orcid":false,"given":"S\u00edlvio Gomes","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Mestrado em Meio Ambiente da Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-2794","authenticated-orcid":false,"given":"Maria Cl\u00e1udia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Mestrado em Meio Ambiente da Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9878-0206","authenticated-orcid":false,"given":"Fabr\u00edcio Brito","family":"Silva","sequence":"additional","affiliation":[{"name":"Mestrado em Meio Ambiente da Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-5663","authenticated-orcid":false,"given":"Rodrigo Assuncao","family":"Holanda","sequence":"additional","affiliation":[{"name":"Mestrado em Biologia Microbiana da Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6918-1186","authenticated-orcid":false,"given":"Julliana Ribeiro Alves","family":"Santos","sequence":"additional","affiliation":[{"name":"Mestrado em Meio Ambiente e Mestrado em Biologia Microbiana da Universidade CEUMA, S\u00e3o Lu\u00eds 65075-120, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Castro, I.P.S., and Viana, M.B. 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