{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:15:45Z","timestamp":1790259345013,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The increasing incidence of Candida albicans infections and resistance to current antifungal therapies has led to the search for new and more effective antifungal compounds. Actinobacterial species from the Streptomyces genus are recognized as some of the major producers of antimicrobial compounds. Therefore, the aims of this study were: (1) the identification of Streptomyces strains isolated from Mexican tropical acidic soils, (2) the evaluation of their antifungal activity on C. albicans, and (3) the exploration of the presence of polyketide synthase genes in their genome and antifungal secondary metabolites in their extracts. Four actinobacterial strains, isolated from previously unexplored soils with antibacterial antecedents, were selected. These strains were identified as Streptomyces angustmyceticus S6A-03, Streptomyces manipurensis S3A-05 and S3A-09, and Streptomyces parvisporogenes S2A-04, according to their molecular analyses. The ethanol extract of the lyophilized supernatant of S. parvisporogenes displayed the most interesting antifungal activity against C. albicans, with a minimum inhibitory concentration (MIC) of 0.5 mg\/mL. Type I polyketide synthase (PKS-I) and non-ribosomal peptide synthase (NRPS) genes were detected in all strains. In addition, type II PKS genes (PKS-II) were also found in S. manipurensis S3A-05 and S. parvisporogenes. LC-UV-HRMS analysis of the active organic extract of S. parvisporogenes indicated the presence of the known antifungal compound carbazomycin G as the major component.<\/jats:p>","DOI":"10.3390\/ijerph16111913","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T11:07:44Z","timestamp":1559214464000},"page":"1913","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Molecular Identification of Selected Streptomyces Strains Isolated from Mexican Tropical Soils and their Anti-Candida Activity"],"prefix":"10.3390","volume":"16","author":[{"given":"Diana","family":"Escalante-R\u00e9ndiz","sequence":"first","affiliation":[{"name":"Unidad de Biotecnolog\u00eda, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n (CICY), Calle 43 x 32 y 34, Chuburna de Hidalgo, M\u00e9rida, Yucat\u00e1n 97205, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-4532","authenticated-orcid":false,"given":"Susana","family":"de-la-Rosa-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Aplicada, Divisi\u00f3n Acad\u00e9mica de Ciencias Biol\u00f3gicas, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco (UJAT), Villahermosa, Tabasco 86150, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Tapia-Tussell","sequence":"additional","affiliation":[{"name":"Unidad de Energ\u00eda Renovable, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n (CICY), Calle 43 x 32 y 34, Chuburna de Hidalgo, M\u00e9rida, Yucat\u00e1n 97205, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Avda Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-5106","authenticated-orcid":false,"given":"Fernando","family":"Reyes","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Avda Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Vicente","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Avda Conocimiento 34, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-0335","authenticated-orcid":false,"given":"Marcela","family":"Gamboa-Angulo","sequence":"additional","affiliation":[{"name":"Unidad de Biotecnolog\u00eda, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n (CICY), Calle 43 x 32 y 34, Chuburna de Hidalgo, M\u00e9rida, Yucat\u00e1n 97205, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mib.2017.10.030","article-title":"Candida albicans\u2013epithelial interactions and induction of mucosal innate immunity","volume":"40","author":"Naglik","year":"2017","journal-title":"Curr. 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