{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T03:49:08Z","timestamp":1770781748952,"version":"3.50.0"},"reference-count":39,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["2U50\/OH009739 and 5U50\/OH009739"],"award-info":[{"award-number":["2U50\/OH009739 and 5U50\/OH009739"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Asthma control is suboptimal among World Trade Center Health Registry (WTCHR) enrollees. Air pollution\/irritants have been reported as the most prevalent trigger among World Trade Center responders. We examined the relationship between air pollution\/irritants and asthma control. We also evaluated the association of asthma control with health-related quality of life (HRQoL). We included 6202 enrollees age \u226518 with a history of asthma who completed the WTCHR asthma survey between 2015 and 2016. Based on modified National Asthma Education and Prevention Program criteria, asthma was categorized as controlled, poorly-controlled, or very poorly-controlled. HRQoL indicators include \u226514 unhealthy days, \u226514 activity limitation days, and self-rated general health. We used multinomial logistic regression for asthma control, and unconditional logistic regression for HRQoL, adjusting for covariates. Overall, 27.1% had poorly-controlled and 32.2% had very poorly-controlled asthma. Air pollution\/irritants were associated with poorly-controlled (adjusted odds ratio (AOR) = 1.70; 95% CI = 1.45\u20131.99) and very poorly-controlled asthma (AOR = 2.15; 95% CI = 1.83\u20132.53). Poor asthma control in turn worsened the HRQoL of asthmatic patients. Very poorly-controlled asthma was significantly associated with \u226514 unhealthy days (AOR = 3.60; 95% CI = 3.02\u20134.30), \u226514 activity limitation days (AOR = 4.37; 95% CI = 3.48\u20135.50), and poor\/fair general health status (AOR = 4.92; 95% CI = 4.11\u20135.89). Minimizing World Trade Center (WTC) asthmatic patients\u2019 exposure to air pollution\/irritants may improve their disease management and overall well-being.<\/jats:p>","DOI":"10.3390\/ijerph16111924","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T11:07:44Z","timestamp":1559214464000},"page":"1924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Air Pollution\/Irritants, Asthma Control, and Health-Related Quality of Life among 9\/11-Exposed Individuals with Asthma"],"prefix":"10.3390","volume":"16","author":[{"given":"Janette","family":"Yung","sequence":"first","affiliation":[{"name":"New York City Department of Health and Mental Hygiene, World Trade Center Health Registry, New York, NY 10013, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhminder","family":"Osahan","sequence":"additional","affiliation":[{"name":"New York City Department of Health and Mental Hygiene, World Trade Center Health Registry, New York, NY 10013, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Friedman","sequence":"additional","affiliation":[{"name":"New York City Department of Health and Mental Hygiene, World Trade Center Health Registry, New York, NY 10013, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehui","family":"Li","sequence":"additional","affiliation":[{"name":"New York City Department of Health and Mental Hygiene, World Trade Center Health Registry, New York, NY 10013, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Cone","sequence":"additional","affiliation":[{"name":"New York City Department of Health and Mental Hygiene, World Trade Center Health Registry, New York, NY 10013, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1513\/AnnalsATS.201703-259OC","article-title":"The Economic Burden of Asthma in the United States, 2008\u20132013","volume":"15","author":"Nurmagambetov","year":"2018","journal-title":"Ann. 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