{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:39:32Z","timestamp":1790080772245,"version":"4.0.1"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Long-term continuous exposure to potentially inappropriate medications (PIMs) can lead to adverse events in the elderly. However, the effects of long-term exposure of the elderly to PIM and the relationship between PIM and chronic diseases remain unclear. The objective of this study was to investigate the continuous use of PIMs in a community-dwelling elderly population. A cross-sectional population-based study was conducted using community pharmacy\u2013filed dispensing records from the Hcare system. Twenty-three community pharmacies were sampled from 2013 to 2015 to obtain records of patients above 65 years-old with continuous prescriptions. PIM were identified according to the 2015 Beers Criteria. The prevalence of patients using PIM was highest in patients with co-morbid mental disorders (40.05%), followed by neurological system disorders (28.91%). Patients who were prescribed a PIM were more than three times as likely to have a mental disorder as those (odds ratio 3.16, 95% confidence interval: 3.06\u20133.28) with non-chronic diseases. The most prescribed PIM agents were central nervous system drugs (53.16%), and benzodiazepines (35.15%). Patients with mental disorders had the highest rate of long-term persistent PIM exposure, with benzodiazepines being the most frequently dispensed. Drug safety concerns should be closely monitored in elderly patients with the abovementioned conditions.<\/jats:p>","DOI":"10.3390\/ijerph16122189","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T11:54:31Z","timestamp":1561118071000},"page":"2189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-3276","authenticated-orcid":false,"given":"Tzu-Chueh","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pou-Jen","family":"Ku","sequence":"additional","affiliation":[{"name":"Taiwan Pharmacist Association, Taipei City 10452, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Information Management, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7541-8976","authenticated-orcid":false,"given":"Kung-Chuan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Giraffe Pharmacy, Tainan City 71049, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Trezise","sequence":"additional","affiliation":[{"name":"Department of Applied Foreign Languages, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-2699","authenticated-orcid":false,"given":"Hue-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan"},{"name":"Department of Pharmacy, Chi-Mei Medical Center, Tainan City 71004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jama.287.3.337","article-title":"Recent patterns of medication use in the ambulatory adult population of the United States: The Slone survey","volume":"287","author":"Kaufman","year":"2002","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s002280000157","article-title":"The consumption of drugs by 75-year-old individuals living in their own homes","volume":"56","author":"Barat","year":"2000","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1590\/S0034-89102004000200012","article-title":"Drug utilization in adults: Prevalence and individuals determinants","volume":"38","author":"Bertoldi","year":"2004","journal-title":"Rev. Saude Publica"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1590\/S0034-89102008000400020","article-title":"A survey on medicine use by elderly retirees in Belo Horizonte, Southeastern Brazil","volume":"42","author":"Ribeiro","year":"2008","journal-title":"Rev. Saude Publica"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1590\/S1020-49892008000100005","article-title":"Drug utilization and polypharmacy among the elderly: A survey in Rio de Janeiro City, Brazil","volume":"23","author":"Rozenfeld","year":"2008","journal-title":"Rev. Panam. Salud Publica"},{"key":"ref_6","first-page":"1313","article-title":"Drugs and the elderly, Part 1: The problems facing managed care","volume":"6","author":"Beers","year":"2000","journal-title":"Am. J. Manag. Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2165\/11584850-000000000-00000","article-title":"Comparison of published explicit criteria for potentially inappropriate medications in older adults","volume":"27","author":"Chang","year":"2010","journal-title":"Drugs Aging"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1345\/aph.1H473","article-title":"Healthcare outcomes associated with beers\u2019 criteria: A systematic review","volume":"41","author":"Jano","year":"2007","journal-title":"Ann. Pharmacother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0140-6736(07)61091-5","article-title":"Appropriate prescribing in elderly people: How well can it be measured and optimised?","volume":"370","author":"Spinewine","year":"2007","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/geroni\/igx004.3830","article-title":"Comparing the explicit tools vs. Implicit evaluation among turkish geriatric outpatients","volume":"1","author":"Bahat","year":"2017","journal-title":"Innov. Aging"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"(2015). By the American Geriatrics Society Beers Criteria Update Expert Panel, American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J. Am. Geriatr. Soc., 63, 2227\u20132246.","DOI":"10.1111\/jgs.13702"},{"key":"ref_12","first-page":"407","article-title":"Potentially Inappropriate Medication Use in a Medicare Managed Care Population: Association with Higher Costs and Utilization","volume":"7","author":"Fick","year":"2001","journal-title":"J. Manag. Care Pharm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1097\/MLR.0000000000000587","article-title":"A Systematic Review of the Impact of Potentially Inappropriate Medication on Health Care Utilization and Costs Among Older Adults","volume":"54","author":"Hyttinen","year":"2016","journal-title":"Med. Care"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Reich, O., Rosemann, T., Rapold, R., Blozik, E., and Senn, O. (2014). Potentially inappropriate medication use in older patients in Swiss managed care plans: Prevalence, determinants and association with hospitalization. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105425"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"747","DOI":"10.2165\/11538240-000000000-00000","article-title":"Potentially inappropriate drug prescriptions and risk of hospitalization among older, Italian, nursing home residents: The ULISSE project","volume":"27","author":"Ruggiero","year":"2010","journal-title":"Drugs Aging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.clinthera.2009.08.023","article-title":"Prevalence of the prescribing of potentially inappropriate medications at ambulatory care visits by elderly patients covered by the Taiwanese National Health Insurance program","volume":"31","author":"Lai","year":"2009","journal-title":"Clin. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Nam, Y.-S., Han, J.S., Kim, J.Y., Bae, W.K., and Lee, K. (2016). Prescription of potentially inappropriate medication in Korean older adults based on 2012 Beers Criteria: A cross-sectional population based study. BMC Geriatr., 16.","DOI":"10.1186\/s12877-016-0285-3"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2165\/00002512-200825010-00006","article-title":"Association of potentially inappropriate medication use with adverse outcomes in ambulatory elderly patients with chronic diseases: Experience in a Taiwanese medical setting","volume":"25","author":"Lin","year":"2008","journal-title":"Drugs Aging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/MLR.0b013e31826c870f","article-title":"Continuity of care, potentially inappropriate medication, and health care outcomes among the elderly: Evidence from a longitudinal analysis in Taiwan","volume":"50","author":"Chu","year":"2012","journal-title":"Med. Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1503\/cmaj.141219","article-title":"Effect of polypharmacy, potentially inappropriate medications and anticholinergic burden on clinical outcomes: A retrospective cohort study","volume":"187","author":"Lu","year":"2015","journal-title":"CMAJ"},{"key":"ref_21","first-page":"3","article-title":"Prevalence of chronic diseases among older patients in German general practices","volume":"14","author":"Jacob","year":"2016","journal-title":"Ger. Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2105\/AJPH.2007.121137","article-title":"Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden","volume":"98","author":"Marengoni","year":"2008","journal-title":"Am. J. Public Health"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wu, F., Guo, Y., Kowal, P., Jiang, Y., Yu, M., Li, X., Zheng, Y., and Xu, J. (2013). Prevalence of major chronic conditions among older Chinese adults: The Study on Global AGEing and adult health (SAGE) wave 1. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074176"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1177\/003335491012500502","article-title":"Multiple chronic conditions: A public health challenge","volume":"125","author":"Benjamin","year":"2010","journal-title":"Public Health Rep."},{"key":"ref_25","unstructured":"(2019, April 20). National Health Insurance Administration List of Chronic Disease Included, Available online: https:\/\/www.nhi.gov.tw\/Content_List.aspx?n=0205B47A1C459B5A&topn=D39E2B72B0BDFA15."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Guaraldo, L., Cano, F.G., Damasceno, G.S., and Rozenfeld, S. (2011). Inappropriate medication use among the elderly: A systematic review of administrative databases. BMC Geriatr., 11.","DOI":"10.1186\/1471-2318-11-79"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sheikh-Taha, M., and Dimassi, H. (2017). Potentially inappropriate home medications among older patients with cardiovascular disease admitted to a cardiology service in USA. BMC Cardiovasc. Disord., 17.","DOI":"10.1186\/s12872-017-0623-1"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4140\/TCP.n.2017.525","article-title":"Potentially Inappropriate Medication Prescribing in U.S. Older Adults with Selected Chronic Conditions","volume":"32","author":"Swanoski","year":"2017","journal-title":"Consult. Pharm."},{"key":"ref_29","first-page":"11","article-title":"Prevalence of potentially inappropriate medication use and drug utilization pattern in elderly patients: A prospective study from a tertiary care hospital","volume":"3","author":"Kanagasanthosh","year":"2017","journal-title":"Int. J. Res. Med. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/ageing\/afq031","article-title":"Potentially inappropriate prescribing including under-use amongst older patients with cognitive or psychiatric co-morbidities","volume":"39","author":"Lang","year":"2010","journal-title":"Age Ageing"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E187","DOI":"10.5888\/pcd11.140205","article-title":"Trends in the prevalence of multiple chronic conditions in Taiwan from 2000 to 2010: A population-based study","volume":"11","author":"Fu","year":"2014","journal-title":"Prev. Chronic Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF03169170","article-title":"Regional variation in prescribing for chronic conditions among an elderly population using a pharmacy claims database","volume":"175","author":"Naughton","year":"2006","journal-title":"Ir. J. Med. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1159\/000435955","article-title":"Potentially Inappropriate Prescribing in Disabled Older Patients with Chronic Diseases: A Screening Tool of Older Persons\u2019 Potentially Inappropriate Prescriptions versus Beers 2012 Criteria","volume":"24","author":"Yang","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00228-015-1815-1","article-title":"Longitudinal prevalence of potentially inappropriate medicines and potential prescribing omissions in a cohort of community-dwelling older people","volume":"71","author":"Moriarty","year":"2015","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1001\/jama.286.22.2823","article-title":"Potentially inappropriate medication use in the community-dwelling elderly: Findings from the 1996 Medical Expenditure Panel Survey","volume":"286","author":"Zhan","year":"2001","journal-title":"JAMA"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Vieira de Lima, T.J., Garbin, C.A., Garbin, A.J., Sumida, D.H., and Saliba, O. (2013). Potentially inappropriate medications used by the elderly: Prevalence and risk factors in Brazilian care homes. BMC Geriatr., 13.","DOI":"10.1186\/1471-2318-13-52"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/j.1532-5415.2012.04012.x","article-title":"Potentially inappropriate medication use in individuals with mild cognitive impairment: Results from the Kerala Einstein Study","volume":"60","author":"Tsai","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/2042098613486829","article-title":"Drug-related falls in older patients: Implicated drugs, consequences, and possible prevention strategies","volume":"4","author":"Hartholt","year":"2013","journal-title":"Ther. Adv. Drug Saf."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3928\/00989134-20090731-01","article-title":"Psychotropic medication use among older adults: What all nurses need to know","volume":"35","author":"Lindsey","year":"2009","journal-title":"J. Gerontol. Nurs."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4103\/2229-516X.205822","article-title":"Adverse Drug Events in Patients with Mental Disorder in an Ambulatory Setting","volume":"7","author":"Kumar","year":"2017","journal-title":"Int. J. Appl. Basic Med. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1176\/appi.ps.201100443","article-title":"Exposure to potentially dangerous drug-drug interactions involving antipsychotics","volume":"63","author":"Guo","year":"2012","journal-title":"Psychiatr. Serv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/106002809202600722","article-title":"Metoclopramide: An analysis of inappropriate long-term use in the elderly","volume":"26","author":"Stewart","year":"1992","journal-title":"Ann. Pharmacother."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"(2019). By the American Geriatrics Society Beers Criteria Update Expert Panel, American Geriatrics Society 2019 Updated AGS Beers Criteria (R) for Potentially Inappropriate Medication Use in Older Adults. J. Am. Geriatr. Soc., 67, 674\u2013694.","DOI":"10.1111\/jgs.15767"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/12\/2189\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:00:07Z","timestamp":1760187607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/12\/2189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":43,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["ijerph16122189"],"URL":"https:\/\/doi.org\/10.3390\/ijerph16122189","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,20]]}}}