{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:47:42Z","timestamp":1792072062333,"version":"4.4.0"},"reference-count":35,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Amsterdam, The Netherlands","award":["X7605"],"award-info":[{"award-number":["X7605"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Purpose: Hypertension is a major risk factor for cardiovascular diseases and stroke, and it requires lifelong medication. This study aimed to investigate the factors impacting on Health-Related Quality of Life (HRQoL) among hypertensive patients in Chongqing, China, and to provide evidence-based strategies to improve their HRQoL. Methods: This cross-sectional survey was conducted in Chongqing, China. Of 600 randomly selected patients, 586 patients agreed to participate and 567 patients completed the survey. A SF-36 (Medical Outcomes Study (MOS) Short Form Health Survey questionnaire) that included eight domains: physical functioning, role limitations due to physical problems, body pain, general health, vitality, social function, role limitations due to emotional problems, and mental health was used to measure HRQoL. Linear regressions were used; each domain of HRQoL was measured in the stratification of sex. Results: Self-perceived relatively low economic burden caused by hypertension and regular physical activity had a positive impact on HRQoL (p &lt; 0.05) for both men and women. For women, younger age was associated with higher scores of measuring physical functioning and body pain. Living with more than three family members had a positive impact on domains, including physical functioning. Emotional self-regulation had a positive association with women\u2019s mental health. Alcohol use for men was associated with higher scores in physical and mental health measures, and emotional self-regulation showed some positive impact on general health. Conclusion: Perceived economic burden caused by hypertension was the most common factor impacting on patients\u2019 HRQoL. Female patients were more susceptible when compared to male patients. Health intervention strategies need to be further explored and adapted to the context of improving HRQoL for patients who suffer from hypertension and other chronic non-communicable diseases.<\/jats:p>","DOI":"10.3390\/ijerph16132348","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T11:14:49Z","timestamp":1562152489000},"page":"2348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Health-Related Quality of Life of Hypertension Patients: A Population-Based Cross-Sectional Study in Chongqing, China"],"prefix":"10.3390","volume":"16","author":[{"given":"Meng","family":"Xiao","sequence":"first","affiliation":[{"name":"School of Public Health and Management, Research Center for Medicine and Social Development, Collaborative Innovation Center of Social Risks Governance in Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health and Management, Research Center for Medicine and Social Development, Collaborative Innovation Center of Social Risks Governance in Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanzi","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Public Health and Management, Research Center for Medicine and Social Development, Collaborative Innovation Center of Social Risks Governance in Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Bu","sequence":"additional","affiliation":[{"name":"School of Public Health and Management, Research Center for Medicine and Social Development, Collaborative Innovation Center of Social Risks Governance in Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Public Health and Management, Research Center for Medicine and Social Development, Collaborative Innovation Center of Social Risks Governance in Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-6815","authenticated-orcid":false,"given":"Qian","family":"Long","sequence":"additional","affiliation":[{"name":"Global Health Research Center, Duke Kunshan University, Kunshan 215316, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2019, June 28). Global Status Report on Noncommunicable Diseases 2014. Available online: http:\/\/www.who.int\/nmh\/publications\/ncd-status-report-2014\/en\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/jech-2015-206492","article-title":"Prevalence of hypertension subtypes in 2011 and the trends from 1991 to 2011 among Chinese adults","volume":"70","author":"Qi","year":"2015","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1136\/bmj.39548.738368.BE","article-title":"Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: Meta-analysis of randomised trials","volume":"336","author":"Turnbull","year":"2008","journal-title":"BMJ Br. Med. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/BJMMR\/2015\/18897","article-title":"Role of hypertension as a major risk factor of stroke in africa; libya: Community based survey","volume":"9","author":"Shambesh","year":"2015","journal-title":"Br. J. Med. Med. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0895-7061(00)01246-2","article-title":"A systematic review of predictors of maintenance of normotension after withdrawal of antihypertensive drugs","volume":"14","author":"Nelson","year":"2001","journal-title":"Am. J. Hypertens."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"121.e1","DOI":"10.1016\/j.urolonc.2015.10.006","article-title":"Orthotopic neobladder vs. ileal conduit urinary diversion: A long-term quality-of-life comparison","volume":"34","author":"Goldberg","year":"2016","journal-title":"Urologic Oncol."},{"key":"ref_7","first-page":"167","article-title":"Health-related quality of life after radical cystectomy for bladder cancer: A comparison of ileal conduit and orthotopic bladder replacement","volume":"21","author":"Hara","year":"2015","journal-title":"J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cpr.2015.11.007","article-title":"Quality of life in children: A critical examination of concepts, approaches, issues, and future directions","volume":"45","author":"Wallander","year":"2016","journal-title":"Clin. Psychol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1007\/s11136-018-1902-8","article-title":"Comparison of health-related quality of life (HRQoL) between ileal conduit diversion and orthotopic neobladder based on validated questionnaires: A systematic review and meta-analysis","volume":"27","author":"Shi","year":"2018","journal-title":"Qual. Life Res."},{"key":"ref_11","unstructured":"Chongqing (2019, June 28). Wikipedia. Available online: https:\/\/en.wikipedia.org\/wiki\/Chongqing."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/HJH.0000000000001203","article-title":"Hypertension prevalence, awareness, treatment, control, and associated factors in southwest China: An update","volume":"35","author":"Liu","year":"2017","journal-title":"J. Hypertens."},{"key":"ref_13","unstructured":"(2019, June 24). Health Management Service Standard for Hypertensive Patients. (In Chinese)."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1111\/j.1365-2702.2010.03295.x","article-title":"Relationship between diabetes mellitus, hypertension and obesity, and health-related quality of life in gaziantep, a central south-eastern city in turkey","volume":"19","author":"Ucan","year":"2010","journal-title":"J. Clin. Nurs."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1097\/01.hjh.0000174971.64589.39","article-title":"Hypertension and health-related quality of life: An epidemiological study in patients attending hospital clinics in China","volume":"23","author":"Li","year":"2005","journal-title":"J. Hypertens."},{"key":"ref_16","unstructured":"(2019, June 28). Chongqing Statistical Bureau, Available online: http:\/\/tjj.cq.gov.cn\/\/tjnj\/2017\/indexch.htm."},{"key":"ref_17","unstructured":"State Council of the People\u2019s Republic of China (2019, June 28). Opinions on the Integration of Basic Medical Insurance System for Urban and Rural Residents, Available online: http:\/\/www.gov.cn\/zhengce\/content\/2016-01\/12\/content_10582.htm."},{"key":"ref_18","first-page":"109","article-title":"Factors affecting the quality of life of hypertensive patients","volume":"11","author":"Youssef","year":"2005","journal-title":"EMHJ"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhou, Z., Gao, J., Wang, D., Zhang, Q., Zhou, Z., Su, M., and Li, D. (2016). Health-related quality of life and its influencing factors for patients with hypertension: Evidence from the urban and rural areas of Shaanxi Province, China. BMC Health Serv. Res., 16.","DOI":"10.1186\/s12913-016-1536-x"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12955-018-1016-6","article-title":"Multimorbidity and health-related quality of life in Koreans aged 50 or older using knhanes 2013\u20132014","volume":"16","author":"Park","year":"2018","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1369-7625.2012.00765.x","article-title":"A cross-sectional assessment of health-related quality of life (hrqol) among hypertensive patients in Pakistan","volume":"17","author":"Saleem","year":"2014","journal-title":"Health Expect."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liu, X., Sun, X., Zhao, Y., and Meng, Q. (2016). Financial protection of rural health insurance for patients with hypertension and diabetes: Repeated cross-sectional surveys in rural China. BMC Health Serv. Res., 16.","DOI":"10.1186\/s12913-016-1735-5"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wang, Q., Liu, H., Lu, Z.X., Luo, Q., and Liu, J.A. (2014). Role of the new rural cooperative medical system in alleviating catastrophic medical payments for hypertension, stroke and coronary heart disease in poor rural areas of China. BMC Public Health, 14.","DOI":"10.1186\/1471-2458-14-907"},{"key":"ref_24","first-page":"782","article-title":"Economic burden and economic risk of five major chronic diseases among chinese urban residents","volume":"46","author":"Liu","year":"2014","journal-title":"J. Peking Univ."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s12529-016-9560-0","article-title":"Care Utilization with China\u2019s New Rural Cooperative Medical Scheme: Updated Evidence from the China Health and Retirement Longitudinal Study 2011\u20132012","volume":"23","author":"Zhang","year":"2016","journal-title":"Int. J. Behav. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.socscimed.2008.09.066","article-title":"Non-evidence-based policy: How effective is China\u2019s new cooperative medical scheme in reducing medical impoverishment?","volume":"68","author":"Yip","year":"2009","journal-title":"Soc. Sci. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e018703","DOI":"10.1136\/bmjopen-2017-018703","article-title":"Association of socioeconomic status with financial burden of disease among elderly patients with cardiovascular disease: Evidence from the China health and retirement longitudinal survey","volume":"8","author":"Li","year":"2018","journal-title":"BMJ Open"},{"key":"ref_28","first-page":"1","article-title":"Constructing a value-based healthcare system for hypertensive patients through changing payment mode: Evidence from a comparative study in rural China","volume":"14","author":"Miao","year":"2018","journal-title":"J. Med. Econ."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Writing Group of the PREMIER Collaborative Research Group (2003). Effects of comprehensive lifestyle modification on blood pressure control: Main results of the premier clinical trial. JAMA, 289, 2083\u20132093.","DOI":"10.1001\/jama.289.16.2083"},{"key":"ref_30","first-page":"479","article-title":"Factors influencing the quality of life (qol) among thai older people in a rural area of Thailand","volume":"44","author":"Hongthong","year":"2015","journal-title":"Iran. J. Public Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.annepidem.2009.01.011","article-title":"Moderate alcohol use, health status, and mortality in a prospective Chinese eldely cohort","volume":"19","author":"Sun","year":"2009","journal-title":"Ann. Epidemiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/7404957","article-title":"Hypertension impact on health-related quality of life: A cross-sectional survey among middle-aged adults in Chongqing, China","volume":"2016","author":"Xu","year":"2016","journal-title":"Int. J. Hypertens."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1177\/0733464813490247","article-title":"Correlates of health-related quality of life among Korean immigrant elders","volume":"34","author":"Lee","year":"2013","journal-title":"J. Appl. Gerontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5830\/CVJA-2014-066","article-title":"Social support and management of hypertension in south-west Nigeria","volume":"26","author":"Osamor","year":"2015","journal-title":"Cardiovasc. J. Afr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1183\/16000617.0063-2015","article-title":"Pulmonary arterial hypertension: The burden of disease and impact on quality of life","volume":"24","author":"Delcroix","year":"2015","journal-title":"Eur. Respir. Rev."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/13\/2348\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:02:03Z","timestamp":1760187723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/13\/2348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,3]]},"references-count":35,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["ijerph16132348"],"URL":"https:\/\/doi.org\/10.3390\/ijerph16132348","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,3]]}}}