{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:42:20Z","timestamp":1760240540590,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Dyslipidemia is a primary, critical risk factor for cardiovascular disease. Therefore, evaluating the trends in lipid profiles is crucial for the development of health policies and programs. We studied trends in lipid profiles in Korean adults over an 11-year period according to the use of lipid-lowering medications through age-specific analysis. A total of 73,890 participants were included in the Korean National Health and Nutrition Examination Survey III (2005)-VI (2013\u20132015). The proportion of participants on lipid-lowering medications has increased. This trend was apparent in age groups of over 40 years in both men and women. Lipid-lowering medications successfully reduced mean total cholesterol (TC), but there was no favorable trend in TC in participants not taking lipid-lowering medication in both men and women. Unlike men, triglyceride and non-high-density lipoprotein cholesterol (HDL) decreased in women without lipid-lowering medications. In age-specific hypercholesterolemia, the prevalence of hypercholesterolemia significantly increased in the age groups of 30\u201359 and 30\u201349 years in men and women without lipid-lowering medications, respectively. Meanwhile, mean HDL-C levels increased over the 11-year period regardless of lipid-lowering drug use in both men and women. These analyses identified an upward trend in TC and HDL-C over the 11-year period.<\/jats:p>","DOI":"10.3390\/ijerph16142555","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T11:25:12Z","timestamp":1563362712000},"page":"2555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Secular Trends in Lipid Profiles in Korean Adults Based on the 2005\u20132015 KNHANES"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9021-3856","authenticated-orcid":false,"given":"Yu-Jin","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Korea"},{"name":"Department of Medicine, Graduate School of Yonsei University, Seoul 03722, Korea"},{"name":"Department of Family Medicine, Yong-In Severance Hospital, Yong-In 17046, Gyounggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1784-6494","authenticated-orcid":false,"given":"Jae-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chungbuk National University Hospital, Cheongju 28644, Chungbuk, Korea"},{"name":"Department of Family Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Chungbuk, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-6247","authenticated-orcid":false,"given":"Hee-Taik","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chungbuk National University Hospital, Cheongju 28644, Chungbuk, Korea"},{"name":"Department of Family Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Chungbuk, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics-2017 update: A report from the American heart association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"ref_2","unstructured":"World Health Organization (2017, October 25). 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