{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:26:17Z","timestamp":1788366377219,"version":"build-2803163510"},"reference-count":69,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872638"],"award-info":[{"award-number":["81872638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The association between adverse childhood experiences (ACEs) and pubertal timing has been a topic of enduring controversy. A systematic search of PubMed and Web of Science databases was undertaken to quantify the magnitude of total and specific forms of ACEs effects on early pubertal timing among girls. Our search identified 3280 records, of which 43 studies with 46 independent data sets met inclusion criteria. We estimated pooled effect sizes (Cohen\u2019s ds) for the association between ACEs with early pubertal timing. Total ACEs was not associated with early pubertal timing. When we examined the specific types of ACEs, associations were small to medium for father absence (d = \u22120.40, 95% confidence interval [CI]: \u22120.63, \u22120.16) and small for sexual abuse (d = \u22120.13, CI: \u22120.17, \u22120.10) and family dysfunction (d = \u22120.08, CI: \u22120.11, \u22120.02). We identified considerable heterogeneity between estimates for almost all of the outcomes. ACEs exposure may affect female reproductive reproduction, particularly father absence, sexual abuse, and family dysfunction. We propose that future research in this area test a theoretical model linking adversity with earlier reproductive strategy, which includes early pubertal timing as a core component linking early adversity and stress physiology with poor health outcomes later in life in females.<\/jats:p>","DOI":"10.3390\/ijerph16162887","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T04:31:21Z","timestamp":1565670681000},"page":"2887","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Adverse Childhood Experiences and Early Pubertal Timing Among Girls: A Meta-Analysis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8951-390X","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Maternal, Child &amp; Adolescent Health, School of Public Health, Anhui Medical University, 81th Meishan Road, Hefei 230032, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Maternal, Child &amp; Adolescent Health, School of Public Health, Anhui Medical University, 81th Meishan Road, Hefei 230032, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5432-4620","authenticated-orcid":false,"given":"Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Maternal, Child &amp; Adolescent Health, School of Public Health, Anhui Medical University, 81th Meishan Road, Hefei 230032, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrendo.2015.167","article-title":"Molecular insights into the aetiology of female reproductive ageing","volume":"11","author":"Perry","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000336325","article-title":"Recent secular trends in pubertal timing: Implications for evaluation and diagnosis of precocious puberty","volume":"77","author":"Mouritsen","year":"2012","journal-title":"Horm. Res. Paediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.srhc.2017.03.008","article-title":"Age at menarche and its socioeconomic determinants among female students in an urban area in Bangladesh","volume":"12","author":"Islam","year":"2017","journal-title":"Sex. Reprod. Healthc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.2337\/dc13-0446","article-title":"Age at menarche and type 2 diabetes risk: The EPIC-InterAct study","volume":"36","author":"Elks","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCULATIONAHA.114.010070","article-title":"Age at menarche and risks of coronary heart and other vascular diseases in a large UK cohort","volume":"131","author":"Canoy","year":"2015","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/aje\/kwu113","article-title":"Age at menarche and risks of all-cause and cardiovascular death: A systematic review and meta-analysis","volume":"180","author":"Charalampopoulos","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jadohealth.2011.01.006","article-title":"Does competence mediate the associations between puberty and internalizing or externalizing problems in adolescent girls?","volume":"49","author":"Negriff","year":"2011","journal-title":"J. Adolesc. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mce.2006.04.013","article-title":"Examining the evidence for recent secular changes in the timing of puberty in US children in light of increases in the prevalence of obesity","volume":"254","author":"Himes","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1687-9856-2014-14","article-title":"Early menarche and childhood adversities in a nationally representative sample","volume":"2014","author":"Henrichs","year":"2014","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1161\/CIR.0000000000000536","article-title":"Childhood and Adolescent Adversity and Cardiometabolic Outcomes: A Scientific Statement From the American Heart Association","volume":"137","author":"Suglia","year":"2018","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1192\/bjp.bp.110.080499","article-title":"Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys","volume":"197","author":"Kessler","year":"2010","journal-title":"Br. J. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jadohealth.2016.09.008","article-title":"Childhood Sexual Abuse and Early Timing of Puberty","volume":"60","author":"Noll","year":"2017","journal-title":"J. Adolesc. Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1017\/S0954579410000325","article-title":"Psychopathology and social competence during the transition to adolescence: The role of family adversity and pubertal development","volume":"22","author":"Hipwell","year":"2010","journal-title":"Dev. Psychopathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s10552-008-9284-9","article-title":"Socioeconomic status in relation to early menarche among black and white girls","volume":"20","author":"Braithwaite","year":"2009","journal-title":"Cancer Causes Control"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/jora.12128","article-title":"Pubertal Timing and Tempo: Associations with Childhood Maltreatment","volume":"25","author":"Negriff","year":"2015","journal-title":"J. Res. Adolesc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1017\/S0033291703007530","article-title":"Age of menarche: The role of some psychosocial factors","volume":"33","author":"Romans","year":"2003","journal-title":"Psychol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1037\/0033-2909.130.6.920","article-title":"Timing of pubertal maturation in girls: An integrated life history approach","volume":"130","author":"Ellis","year":"2004","journal-title":"Psychol. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2307\/1131166","article-title":"Childhood experience, interpersonal development, and reproductive strategy: And evolutionary theory of socialization","volume":"62","author":"Belsky","year":"1991","journal-title":"Child Dev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1111\/j.1467-8624.2007.01092.x","article-title":"Family environments, adrenarche, and sexual maturation: A longitudinal test of a life history model","volume":"78","author":"Ellis","year":"2007","journal-title":"Child Dev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/jora.12201","article-title":"Early Childhood Maltreatment and Pubertal Development: Replication in a Population-Based Sample","volume":"26","author":"Mendle","year":"2016","journal-title":"J. Res. Adolesc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/dev.21138","article-title":"Neuroendocrine coupling across adolescence and the longitudinal influence of early life stress","volume":"57","author":"Ruttle","year":"2015","journal-title":"Dev. Psychobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int. J. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jadohealth.2010.07.032","article-title":"Father absence, body mass index, and pubertal timing in girls: Differential effects by family income and ethnicity","volume":"48","author":"Deardorff","year":"2011","journal-title":"J. Adolesc. Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1037\/bul0000106","article-title":"A meta-analytic review of the association between pubertal timing and psychopathology in adolescence: Are there sex differences in risk?","volume":"143","author":"Ullsperger","year":"2017","journal-title":"Psychol. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lo, C.K., Mertz, D., and Loeb, M. (2014). Newcastle-Ottawa Scale: Comparing reviewers\u2019 to authors\u2019 assessments. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-45"},{"key":"ref_26","unstructured":"Agency for Healthcare Research and Quality (2018, July 13). Methods Guide for Effectiveness and Comparative Effectiveness Reviews, Available online: http:\/\/effectivehealthcare.ahrq.gov\/index.cfm\/search-for-guides-reviews-and-reports\/?pageaction = displayproduct&productid = 318."},{"key":"ref_27","unstructured":"Cohen, J. (1998). Statistical Power Analysis for the Behavioral Sciences, Lawrence Erlbaum Associates. [2nd ed.]."},{"key":"ref_28","unstructured":"(2018, July 13). Effect Size Calculator. Available online: https:\/\/cebcp.org\/practical-meta-analysis-effect-size-calculator\/standardized-mean-difference-d\/means-and-standard-deviations\/."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Bornstein, M., Hedges, L.V., Higgins, J.P.T., and Rothstein, H.R. (2009). Introduction to Meta-Analysis, John Wiley & Sons, Ltd.","DOI":"10.1002\/9780470743386"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1037\/1082-989X.8.4.448","article-title":"Effect-size indices for dichotomized outcomes in meta-analysis","volume":"8","year":"2003","journal-title":"Psychol. Methods"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1017\/S0033291715000574","article-title":"The impact of childhood adversity on the persistence of psychotic symptoms: A systematic review and meta-analysis","volume":"45","author":"Trotta","year":"2015","journal-title":"Psychol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/026010609701100304","article-title":"The influence of socioeconomic and nutritional status on menarche in Nigerian school girls","volume":"11","author":"Ojofeitimi","year":"1997","journal-title":"Nutr. Health"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/03014460.2011.552891","article-title":"Menarcheal age in Turkey: Secular trend and socio-demographic correlates","volume":"38","year":"2011","journal-title":"Ann. Hum. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Al-Sahab, B., Ardern, C.I., Hamadeh, M.J., and Tamim, H. (2010). Age at menarche in Canada: Results from the National Longitudinal Survey of Children & Youth. BMC Public Health, 10.","DOI":"10.1186\/1471-2458-10-736"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.physbeh.2008.09.005","article-title":"Developmental plasticity of human reproductive development: Effects of early family environment in modern-day France","volume":"95","author":"Alvergne","year":"2008","journal-title":"Physiol. Behav."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1590\/S0102-311X2012000500016","article-title":"Socioeconomic status and age at menarche in indigenous and non-indigenous Chilean adolescents","volume":"28","author":"Amigo","year":"2012","journal-title":"Cad. Saude Publica"},{"key":"ref_38","first-page":"95","article-title":"A study of menarcheal age in northern iran (rasht)","volume":"24","author":"Asgharnia","year":"2009","journal-title":"Oman Med. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jadohealth.2014.10.002","article-title":"Childhood abuse and early menarche among Peruvian women","volume":"56","author":"Barrios","year":"2015","journal-title":"J. Adolesc. Health."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.biopsycho.2013.02.005","article-title":"Childhood adversity and pubertal timing: Understanding the origins of adulthood cardiovascular risk","volume":"93","author":"Bleil","year":"2013","journal-title":"Biol. Psychol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1017\/S0021932007002696","article-title":"Predictors of age at menarche in the newcastle thousand families study","volume":"40","author":"Blell","year":"2008","journal-title":"J. Biosoc. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.annepidem.2012.08.005","article-title":"A prospective study of childhood social hardships and age at menarche","volume":"22","author":"Harville","year":"2012","journal-title":"Ann. Epidemiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jadohealth.2012.06.006","article-title":"Childhood abuse and age at menarche","volume":"52","author":"Wright","year":"2013","journal-title":"J. Adolesc. Health"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11013-012-9277-8","article-title":"Explanatory models of female pubertal timing: Discordances between cultural models of maturation and the recollection and interpretation of personal developmental experiences","volume":"36","author":"Buzney","year":"2012","journal-title":"Cult. Med. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/03014460310001652239","article-title":"Socio-demographic predictors of age at menarche in a group of Colombian university women","volume":"31","author":"Chavarro","year":"2004","journal-title":"Ann. Hum. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.adolescence.2014.02.003","article-title":"Father absence and timing of menarche in adolescent girls from a UK cohort: The mediating role of maternal depression and major financial problems","volume":"37","author":"Culpin","year":"2014","journal-title":"J. Adolesc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/0301446031000091783","article-title":"Family socio-economic background modified secular trends in age at menarche: Evidence from the Pr\u00f3-Sa\u00fade Study (Rio de Janeiro, Brazil)","volume":"30","author":"Faerstein","year":"2003","journal-title":"Ann. Hum. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/01443619750113861","article-title":"Menarcheal age of school girls in the city of Jeddah, Saudia Arabia","volume":"17","year":"1997","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.earlhumdev.2003.11.001","article-title":"Effects of different socioeconomic conditions on menarche in Turkish female students","volume":"76","author":"Ersoy","year":"2004","journal-title":"Early Hum. Dev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2307\/1131582","article-title":"The antecedents of menarcheal age: Heredity, family environment, and stressful life events","volume":"66","author":"Graber","year":"1995","journal-title":"Child Dev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.annepidem.2010.08.006","article-title":"The impact of socioeconomic status across early life on age at menarche among a racially diverse population of girls","volume":"20","author":"Tehranifar","year":"2010","journal-title":"Ann. Epidemiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ajmg.b.20114","article-title":"Association of adverse childhood experiences, age of menarche, and adult reproductive behavior: Does the androgen receptor gene play a role?","volume":"125","author":"Jorm","year":"2004","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/archdischild-2016-310475","article-title":"Early puberty in 11-year-old girls: Millennium Cohort Study findings","volume":"102","author":"Kelly","year":"2017","journal-title":"Arch. Dis. Child."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/jech-2017-209488","article-title":"Childhood psychosocial adversity and female reproductive timing: A cohort study of the ALSPAC mothers","volume":"72","author":"Magnus","year":"2018","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ajhb.20508","article-title":"Family composition and menarcheal age: Anti-inbreeding strategies","volume":"18","author":"Matchock","year":"2006","journal-title":"Am. J. Hum. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1037\/0012-1649.42.3.533","article-title":"Family structure and age at menarche: A children-of-twins approach","volume":"42","author":"Mendle","year":"2006","journal-title":"Dev. Psychol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2307\/1130900","article-title":"Childhood experience and the onset of menarche: A test of a sociobiological model","volume":"63","author":"Moffitt","year":"1992","journal-title":"Child Dev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ajhb.1310070609","article-title":"Age at menarche: Relationships to socioeconomic status, growth rate in stature and weight, and skeletal and sexual maturation","volume":"7","author":"Onat","year":"1995","journal-title":"Am. J. Hum. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/01443615.2011.638092","article-title":"Menarcheal and pubertal development and determining factors among schoolgirls in Kumasi, Ghana","volume":"32","author":"Stowe","year":"2012","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e20164099","DOI":"10.1542\/peds.2016-4099","article-title":"Childhood Social Disadvantage and Pubertal Timing: A National Birth Cohort from Australia","volume":"139","author":"Sun","year":"2017","journal-title":"Pediatrics"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1007\/s004310050981","article-title":"Menarchal age and the stress of war: An example from Bosnia","volume":"157","year":"1998","journal-title":"Eur. J. Pediatr."},{"key":"ref_62","first-page":"138","article-title":"Secular trend of menarche age in an immigrant urban city in Turkey: Izmir","volume":"56","author":"Vatansever","year":"2014","journal-title":"Turk. J. Pediatr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1037\/a0013065","article-title":"Impact of fathers on daughters\u2019 age at menarche: A genetically and environmentally controlled sibling study","volume":"44","author":"Tither","year":"2008","journal-title":"Dev. Psychol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5644\/ama2006-124.140","article-title":"Effect of family disintegration on age at menarche","volume":"44","year":"2015","journal-title":"Acta Med. Acad."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1037\/0012-1649.41.3.553","article-title":"A life history assessment of early childhood sexual abuse in women","volume":"41","author":"Vigil","year":"2005","journal-title":"Dev. Psychol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"S460","DOI":"10.2105\/AJPH.2008.149005","article-title":"Childhood abuse and early menarche: Findings from the black women\u2019s health study","volume":"99","author":"Wise","year":"2009","journal-title":"Am. J. Public Health"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1542\/peds.99.4.505","article-title":"Secondary sexual characteristics and menses in young girls seen in office practice: A study from the Pediatric Research in Office Settings network","volume":"99","author":"Slora","year":"1997","journal-title":"Pediatrics"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1086\/jar.38.3.3629848","article-title":"Father absence and reproductive strategy: An evolutionary perspective","volume":"38","author":"Draper","year":"1982","journal-title":"J. Anthropol. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1037\/0022-3514.77.2.387","article-title":"Quality of early family relationships and individual differences in the timing of pubertal maturation in girls: A longitudinal test of an evolutionary model","volume":"77","author":"Ellis","year":"1999","journal-title":"J. Personal. Soc. Psychol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/16\/2887\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:10:37Z","timestamp":1760188237000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/16\/2887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":69,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2019,8]]}},"alternative-id":["ijerph16162887"],"URL":"https:\/\/doi.org\/10.3390\/ijerph16162887","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,13]]}}}