{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:39:38Z","timestamp":1784075978932,"version":"3.55.0"},"reference-count":56,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Wroclaw Medical University","doi-asserted-by":"publisher","award":["statutory research, project No. ST.A100.16.028"],"award-info":[{"award-number":["statutory research, project No. ST.A100.16.028"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Cadmium exposure contributes to internal organ dysfunction and the development of chronic diseases. The aim of the study was to assess the alleviating effect of \u03b1-lipoic acid and\/or magnesium on cadmium-induced oxidative stress and disorders in bone metabolism, kidney and liver function, and hematological and biochemical parameters changes. Male rats were exposed to cadmium (30 mg Cd\/kg of feed) for three months. Some animals exposed to Cd were supplemented with magnesium (150 mg Mg\/kg of feed) and\/or with \u03b1-lipoic acid (100 mg\/kg body weight, four times a week). Cd intake inhibited body weight gain and lowered hemoglobin concentration, whereas it increased the activities of liver enzymes, as well as the level of oxidative stress, CTX-1 (C-terminal telopeptide of type I collagen, bone resorption marker), and CRP (C-reactive protein, marker of inflammation); it decreased vitamin D3, GSH (reduced glutathione), and the serum urea nitrogen\/creatinine index. Mg and\/or \u03b1-lipoic acid supplementation increased the antioxidant potential, and partially normalized the studied biochemical parameters. The obtained results show that both magnesium and \u03b1-lipoic acid decrease oxidative stress and the level of inflammatory marker, as well as normalize bone metabolism and liver and kidney function. Combined intake of \u03b1-lipoic acid and magnesium results in reinforcement of the protective effect; especially, it increases antioxidant defense.<\/jats:p>","DOI":"10.3390\/ijerph16224483","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T10:56:34Z","timestamp":1573728994000},"page":"4483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Alleviating Effect of \u03b1-Lipoic Acid and Magnesium on Cadmium-Induced Inflammatory Processes, Oxidative Stress and Bone Metabolism Disorders in Wistar Rats"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-5746","authenticated-orcid":false,"given":"Iwona","family":"Markiewicz-G\u00f3rka","sequence":"first","affiliation":[{"name":"Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, Wroclaw, 50-345, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Pawlas","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, Wroclaw, 50-345, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Jaremk\u00f3w","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, Wroclaw, 50-345, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Januszewska","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, Wroclaw, 50-345, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Paw\u0142owski","sequence":"additional","affiliation":[{"name":"Specialist Hospital dr Alfred Soko\u0142owski, Soko\u0142owskiego 4, Wa\u0142brzych 58-309, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-9371","authenticated-orcid":false,"given":"Natalia","family":"Pawlas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 38, Zabrze 41-808, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"The characteristics, toxicity and effects of cadmium","volume":"3","author":"Honey","year":"2015","journal-title":"Int. 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