{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:51:28Z","timestamp":1760241088100,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI grant","award":["JP17K01500"],"award-info":[{"award-number":["JP17K01500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Chronic-phase worsening renal function (WRF) in patients with acute myocardial infarction (AMI) has been associated with poor prognosis. However, there is no consensus on either the method of prevention or the cause. The aim of this study was to determine factors predictive of chronic-phase WRF from the viewpoint of circulatory dynamics response to exercise during hospitalization of AMI patients without renal dysfunction on admission. We studied 186 consecutively AMI patients who underwent the 200-m walk test. Chronic-phase WRF was defined as a 20% decrease in estimated glomerular filtration rate (eGFR) from baseline to 8\u201310 months after AMI onset. Heart rate (HR) and systolic blood pressure recorded during the 200-m walk test were evaluated as circulatory dynamics responses. In total, 94 patients were enrolled. Multiple linear regression analysis showed that \u0394HR (peak-rest) associated significantly with \u0394eGFR (\u03b2 = 0.427, p = 0.018). The receiver operating characteristic curve of \u0394HR to predict chronic-phase WRF showed an area under the curve of 0.77, with a cut-off value of 22.0 bpm having a 95% sensitivity and 55% specificity. Among circulatory dynamics responses during exercise in the acute phase after AMI, \u0394HR was an independent predictor of chronic-phase WRF.<\/jats:p>","DOI":"10.3390\/ijerph16234785","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T10:58:21Z","timestamp":1575025101000},"page":"4785","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased Heart Rate during Walk Test Predicts Chronic-Phase Worsening of Renal Function in Patients with Acute Myocardial Infarction and Normal Kidney Function"],"prefix":"10.3390","volume":"16","author":[{"given":"Asami","family":"Ogura","sequence":"first","affiliation":[{"name":"Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe 654-0142, Japan"},{"name":"Department of Rehabilitation, Sanda City Hospital, Sanda 669-1311, Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP), Kobe 654-0142, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7262-8903","authenticated-orcid":false,"given":"Kazuhiro P.","family":"Izawa","sequence":"additional","affiliation":[{"name":"Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe 654-0142, Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP), Kobe 654-0142, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Tawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanda City Hospital, Sanda 669-1311, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumie","family":"Kureha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanda City Hospital, Sanda 669-1311, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Sanda City Hospital, Sanda 669-1311, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe 654-0142, Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP), Kobe 654-0142, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikko","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe 654-0142, Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP), Kobe 654-0142, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanda City Hospital, Sanda 669-1311, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanda City Hospital, Sanda 669-1311, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.amjmed.2017.02.033","article-title":"Post-discharge worsening renal function in patients with type 2 diabetes and recent acute coronary syndrome","volume":"130","author":"Morici","year":"2017","journal-title":"Am. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.amjcard.2014.02.019","article-title":"Impact of continuous deterioration of kidney function 6 to 8 months after percutaneous coronary intervention for acute coronary syndrome","volume":"113","author":"Nemoto","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jjcc.2014.12.005","article-title":"The prognostic impact of worsening renal function in Japanese patients undergoing percutaneous coronary intervention with acute coronary syndrome","volume":"66","author":"Murata","year":"2015","journal-title":"J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/0003319716646680","article-title":"Persistent renal dysfunction after percutaneous coronary intervention in patients with acute myocardial infarction","volume":"68","author":"Choe","year":"2017","journal-title":"Angiology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00380-011-0177-6","article-title":"Association between deteriorated renal function and long-term clinical outcomes after percutaneous coronary intervention","volume":"27","author":"Ogita","year":"2012","journal-title":"Heart Vessels"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.recesp.2014.04.018","article-title":"Prevalence and prognosis of percutaneous coronary intervention-associated nephropathy in patients with acute coronary syndrome and normal kidney function","volume":"68","author":"Hernando","year":"2015","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"JCS Joint Working Group (2014). Guidelines for rehabilitation in patients with cardiovascular disease (JCS 2012). Circ. J., 78, 2022\u20132093.","DOI":"10.1253\/circj.CJ-66-0094"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.cjca.2015.03.031","article-title":"Acute cardio-renal syndrome as a cause for renal deterioration among myocardial infarction patients treated with primary percutaneous intervention","volume":"31","author":"Shacham","year":"2015","journal-title":"Can. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Revised equation for estimated GFR from serum creatinine in Japan","volume":"53","author":"Matsuo","year":"2009","journal-title":"Am. J. Kidney. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. Heart. J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Asif, M., Jameel, A., Sahito, N., Hwang, J., Hussain, A., and Manzoor, F. (2019). Can leadership enhance patient satisfaction? Assessing the role of administrative and medical quality. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16173212"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00380-018-1291-5","article-title":"Prognostic significance of renal dysfunction and its change pattern on outcomes in patients with acute coronary syndrome treated with emergent percutaneous coronary intervention","volume":"34","author":"Otsuka","year":"2019","journal-title":"Heart Vessels"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.jacc.2008.01.038","article-title":"Assessment of autonomic function in cardiovascular disease: physiological basis and prognostic implications","volume":"51","author":"Lahiri","year":"2008","journal-title":"Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/CIR.0b013e3181e52e69","article-title":"Clinician\u2019s Guide to cardiopulmonary exercise testing in adults. a scientific statement from the American Heart Association","volume":"122","author":"Balady","year":"2010","journal-title":"Circulation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.CIR.0000025610.14665.21","article-title":"Time course of sympathetic neural hyperactivity after uncomplicated acute myocardial infarction","volume":"106","author":"Graham","year":"2002","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bjpt.2017.03.013","article-title":"Safety of early performance of the six-minute walk test following acute myocardial infarction: a cross-sectional study","volume":"21","author":"Diniz","year":"2017","journal-title":"Braz. J. Phys. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1253\/jcj.64.851","article-title":"Impaired heart rate response during incremental exercise in patients with acute myocardial infarction and after coronary artery bypass grafting","volume":"64","author":"Omiya","year":"2000","journal-title":"Jpn. Circ. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1152\/jappl.1991.71.3.1136","article-title":"Autonomic control of heart rate during exercise studied by heart rate variability spectral analysis","volume":"71","author":"Yamamoto","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.rehab.2013.09.003","article-title":"Walking tests during the exercise training: specific use of the cardiac rehabilitation","volume":"56","author":"Casillas","year":"2013","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1152\/ajpheart.00967.2011","article-title":"Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome","volume":"302","author":"Lekawanvijit","year":"2012","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ahj.2004.09.055","article-title":"Inhospital and 1-year mortality of patients who develop worsening renal function following acute ST-elevation myocardial infarction","volume":"150","author":"Goldberg","year":"2005","journal-title":"Am. Heart. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/eurheartj\/ehp188","article-title":"Gender differences in sympathetic neural activation following uncomplicated acute myocardial infarction","volume":"30","author":"Hogarth","year":"2009","journal-title":"Eur. Heart. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00395-016-0556-3","article-title":"Delayed coronary reperfusion is ineffective at impeding the dynamic increase in cardiac efferent sympathetic nerve activity following myocardial ischemia","volume":"111","author":"Hall","year":"2016","journal-title":"Basic. Res. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1152\/japplphysiol.01328.2005","article-title":"Effects of endurance exercise training on heart rate variability and susceptibility to sudden cardiac death: protection is not due to enhanced cardiac vagal regulation","volume":"100","author":"Billman","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_26","first-page":"16","article-title":"Clinical background and hospitalization progress in patients with acute myocardial infarction who experienced cardiac rehabilitation \u2013comparison among age groups\u2013","volume":"61","author":"Tatsuki","year":"2012","journal-title":"J. Rural. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.jacc.2013.02.020","article-title":"Association between gait speed as a measure of frailty and risk of cardiovascular events after myocardial infarction","volume":"61","author":"Matsuzawa","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e24168","DOI":"10.17795\/mejrh-24168","article-title":"Effects of early mobilization program on the heart rate and blood pressure of patients with myocardial infarction hospitalized at the coronary care unit","volume":"2","author":"Asgari","year":"2015","journal-title":"Middle. East. J. Rehabil. Health."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/23\/4785\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:38:31Z","timestamp":1760189911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/23\/4785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,29]]},"references-count":28,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["ijerph16234785"],"URL":"https:\/\/doi.org\/10.3390\/ijerph16234785","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2019,11,29]]}}}