{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T20:04:01Z","timestamp":1786824241174,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained wide attention from researchers and have been considered to be a beneficial adjuvant agent to oral antidiabetic drugs because of their integrated effects. Concerning the various beneficial effects of Nigella sativa, this systematic review aims to provide comprehensive information on the effects of Nigella sativa on glucose and insulin profile status in humans. A computerized database search performed through Scopus and Medline via Ebscohost with the following set of keywords: Nigella Sativa OR black seed oil OR thymoquinone OR black cumin AND diabetes mellitus OR hyperglycemia OR blood glucose OR hemoglobin A1C had returned 875 relevant articles. A total of seven articles were retrieved for further assessment and underwent data extraction to be included in this review. Nigella sativa was shown to significantly improve laboratory parameters of hyperglycemia and diabetes control after treatment with a significant fall in fasting blood glucose, blood glucose level 2 h postprandial, glycated hemoglobin, and insulin resistance, and a rise in serum insulin. In conclusion, these findings suggested that Nigella sativa could be used as an adjuvant for oral antidiabetic drugs in diabetes control.<\/jats:p>","DOI":"10.3390\/ijerph16244911","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T03:16:36Z","timestamp":1575515796000},"page":"4911","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"given":"Amiza","family":"Hamdan","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruszymah","family":"Haji Idrus","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7801-6358","authenticated-orcid":false,"given":"Mohd Helmy","family":"Mokhtar","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.pharmthera.2008.11.009","article-title":"An update on preventive and regenerative therapies in diabetes mellitus","volume":"121","author":"Reimann","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.2174\/1381612811319320005","article-title":"Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases","volume":"19","author":"Fiorentino","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000115118","article-title":"Hyperglycemia and the pathobiology of diabetic complications","volume":"45","author":"Aronson","year":"2008","journal-title":"Adv. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2337\/dc06-1612","article-title":"The loss of postprandial glycemic control precedes stepwise deterioration of fasting with worsening diabetes","volume":"30","author":"Monnier","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejphar.2011.05.051","article-title":"Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients","volume":"666","author":"Derosa","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1155\/2013\/627375","article-title":"New Perspectives on How to Discover Drugs from Herbal Medicines: CAM\u2019s Outstanding Contribution to Modern Therapeutics","volume":"2013","author":"Pan","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S2221-1691(13)60075-1","article-title":"A review on therapeutic potential of Nigella sativa: A miracle herb","volume":"3","author":"Ahmad","year":"2013","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/j.1365-2621.2006.01417.x","article-title":"Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): An overview","volume":"42","author":"Ramadan","year":"2007","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/ptr.1309","article-title":"Pharmacological and toxicological properties of Nigella sativa","volume":"17","author":"Ali","year":"2003","journal-title":"Phytother. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.apjtm.2017.08.020","article-title":"An overview on cardioprotective and anti-diabetic effects of thymoquinone","volume":"10","author":"Farkhondeh","year":"2017","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_11","first-page":"950","article-title":"Thymoquinone: An emerging natural drug with a wide range of medical applications","volume":"17","author":"Khader","year":"2014","journal-title":"Iran. J. Basic Med Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2018\/8104165","article-title":"Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats","volume":"2018","author":"Abdelrazek","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ctim.2017.08.016","article-title":"Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: A systematic review and meta-analysis","volume":"35","author":"Golzarand","year":"2017","journal-title":"Complement. Ther. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1155\/2019\/1528635","article-title":"Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses","volume":"2019","author":"Yimer","year":"2019","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ctim.2015.01.013","article-title":"Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: A systematic review","volume":"23","author":"Heshmati","year":"2015","journal-title":"Complement. Ther. Med."},{"key":"ref_16","first-page":"93","article-title":"Effects of Nigella sativa L. Seed Oil in Type II Diabetic Patients: A Randomized, Double-Blind, Placebo Controlled Clinical Trial","volume":"3","author":"Hosseini","year":"2013","journal-title":"JMPIR"},{"key":"ref_17","first-page":"5373","article-title":"Effects of Nigella sativa oil on some blood parameters in type 2 diabetes mellitus patients","volume":"21","author":"Ahmad","year":"2009","journal-title":"Asian J. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kaatabi, H., Bamosa, A.O., Badar, A., Al-Elq, A., Abou-Hozaifa, B., Lebda, F., Al-Khadra, A., and Al-Almaie, S. (2015). Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: Placebo controlled participant blinded clinical trial. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0113486"},{"key":"ref_19","first-page":"344","article-title":"Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus","volume":"54","author":"Bamosa","year":"2010","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/2230-8229.155380","article-title":"Nigella sativa: A potential natural protective agent against cardiac dysfunction in patients with type 2 diabetes mellitus","volume":"22","author":"Bamosa","year":"2015","journal-title":"J. Fam. Community Med."},{"key":"ref_21","first-page":"1982","article-title":"Effect of Nigella sativa tea in type 2-diabetic patients as regards glucose homeostasis, liver and kidney functions","volume":"7","author":"Mosa","year":"2011","journal-title":"J. Appl. Sci. Res."},{"key":"ref_22","first-page":"768","article-title":"Nutritional, phytochemical potential and pharmacological evaluation of Nigella Sativa (Kalonji) and Trachyspermum Ammi (Ajwain)","volume":"6","author":"Javed","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1126\/science.1217410","article-title":"Mining the Biodiversity of Plants: A Revolution in the Making","volume":"336","author":"Salim","year":"2012","journal-title":"Science"},{"key":"ref_24","unstructured":"Watson, R.R., and Preedy, V.R. (2019). Chapter 40-Nigella sativa: A Medicinal and Edible Plant That Ameliorates Diabetes. Bioactive Food as Dietary Interventions for Diabetes, Academic Press. [2nd ed.]."},{"key":"ref_25","first-page":"14","article-title":"The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats","volume":"2017","author":"Bakhashwain","year":"2017","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.lfs.2009.08.015","article-title":"Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle: A possible trigger for ischemic preconditioning","volume":"85","author":"Kawada","year":"2009","journal-title":"Life Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/0973-3930.41980","article-title":"Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome","volume":"28","author":"Najmi","year":"2008","journal-title":"Int. J. Diabetes Dev. Ctries."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"012018","DOI":"10.1088\/1757-899X\/259\/1\/012018","article-title":"The efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk","volume":"259","author":"Rachman","year":"2017","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"21525","DOI":"10.3390\/ijms141121525","article-title":"Oxidative stress in diabetes: Implications for vascular and other complications","volume":"14","author":"Pitocco","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/1874192401105010153","article-title":"Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart Failure","volume":"5","author":"Soskic","year":"2011","journal-title":"Open Cardiovasc. Med. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.tips.2010.11.006","article-title":"Reactive oxygen species and insulin resistance: The good, the bad and the ugly","volume":"32","author":"Tiganis","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2337\/diab.46.11.1733","article-title":"Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells","volume":"46","author":"Tiedge","year":"1997","journal-title":"Diabetes"},{"key":"ref_34","first-page":"135","article-title":"Ameliorating Effect of Nigella sativa Oil in Thioacetamide-induced Liver Cirrhosis in Albino Rats","volume":"47","author":"Nehar","year":"2013","journal-title":"Indian J. Pharm. Educ. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.rvsc.2004.03.002","article-title":"Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters","volume":"77","author":"Fararh","year":"2004","journal-title":"Res. Vet. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1499-2671(08)24136-5","article-title":"Antidiabetic effects of Nigella sativa are mediated by activation of insulin and AMPK pathways, and by mitochondrial uncoupling","volume":"32","author":"Ali","year":"2008","journal-title":"Can. J. Diabetes"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1081\/DCT-120020404","article-title":"Thymoquinone is a potent superoxide anion scavenger","volume":"26","author":"Badary","year":"2003","journal-title":"Drug Chem. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/MPA.0b013e318279ac1c","article-title":"Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats","volume":"42","year":"2013","journal-title":"Pancreas"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.3923\/pjbs.2005.1152.1156","article-title":"Effects of Oral Administration of Water Extract of Nigella sativa on Serum Concentrations of Insulin and Testosterone in Alloxan-induced Diabetic Rats","volume":"8","year":"2005","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jep.2008.10.040","article-title":"Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats","volume":"121","author":"Meddah","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_41","first-page":"241","article-title":"AMPK activation: A therapeutic target for type 2 diabetes?","volume":"7","author":"Coughlan","year":"2014","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_42","first-page":"2887","article-title":"Analysis on chemical components of volatile oil and determination of thymoquinone from seed of Nigella glandulifera","volume":"34","author":"Geng","year":"2009","journal-title":"Zhongguo Zhong Yao Za Zhi = China J. Chin. Mater. Med."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/24\/4911\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:40:21Z","timestamp":1760190021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/16\/24\/4911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,5]]},"references-count":42,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["ijerph16244911"],"URL":"https:\/\/doi.org\/10.3390\/ijerph16244911","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,5]]}}}