{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:25:00Z","timestamp":1775129100591,"version":"3.50.1"},"reference-count":67,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research","award":["17H01624, 19H01144"],"award-info":[{"award-number":["17H01624, 19H01144"]}]},{"name":"JSPS Core-to-Core Program B. Asia-Africa Science Platforms","award":["."],"award-info":[{"award-number":["."]}]},{"name":"Endowed Chair Program of the Sumitomo Electric Industries Group Corporate Social Responsibility Foundation","award":["."],"award-info":[{"award-number":["."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Psychiatric symptoms have been reported in adult patients with dengue fever (DF); however, information on pediatric patients remains inadequate. We sought to identify the prevalence and predictors of depressive and anxiety symptoms and identify other psychiatric symptoms among pediatric patients with DF. This case-control study involved pediatric in-patients (n = 225) who had clinical or serologic-confirmed DF and healthy school-based controls (n = 260). Participants completed the Revised Child Anxiety and Depression Scale (RCADS). Results: The prevalence of depressive (13.3%) and anxiety (34.2%) symptoms among pediatric patients with DF was significantly (p &lt; 0.001) higher than that among controls (3.5% and 16.2%, respectively). Multiple linear regression analysis found that age, family history of DF, \u22642 days of hospitalization, myalgia, and arthralgia were predictors of increased depressive and anxiety symptoms among the patients. Further, 26.7% of pediatric patients reported irritability, agitation, visual hallucinations, and aggressiveness. Conclusion: Pediatric patients present depressive and anxiety symptoms whose levels were associated with social and clinical factors. However, whether these symptoms are present only during the infection or may still persist after recovery or are brought by children\u2019s adverse reactions to hospitalization are unknown, and thus, further studies are needed.<\/jats:p>","DOI":"10.3390\/ijerph17010099","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:15:01Z","timestamp":1577070901000},"page":"99","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Depressive and Anxiety Symptoms among Pediatric In-Patients with Dengue Fever: A Case-Control Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4840-0153","authenticated-orcid":false,"given":"Von Ralph Dane M.","family":"Herbuela","sequence":"first","affiliation":[{"name":"Graduate School of Science and Engineering, Ehime University, Bunkyo-cho 3, Matsuyama 790-8577, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinand S.","family":"de Guzman","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Infectious Diseases and Tropical Medicine, San Lazaro Hospital, Manila 1003, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girly D.","family":"Sobrepe\u00f1a","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Quezon City General Hospital, Quezon City 1106, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew Benedict F.","family":"Claudio","sequence":"additional","affiliation":[{"name":"Office of Nursing Service, Pasay City General Hospital, Pasay City 1300, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica Cecilia V.","family":"Tomas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of the Philippines, Manila 1000, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmina M.","family":"Arriola-delos Reyes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of the Philippines, Manila 1000, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachele A.","family":"Regalado","sequence":"additional","affiliation":[{"name":"Guidance Department, University of Santo Tomas\u2013Angelicum College, Quezon City 1114, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariama M.","family":"Teodoro","sequence":"additional","affiliation":[{"name":"Counseling and Educational Psychology Department, De La Salle University, Manila 1004, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozo","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Engineering, Ehime University, Bunkyo-cho 3, Matsuyama 790-8577, Japan"},{"name":"Biological Control Research Unit, Center for Natural Science and Environmental Research, De La Salle University, Manila 1004, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,21]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2017, May 03). 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