{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:56:44Z","timestamp":1761562604217,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Patients with either osteoporosis or depression are prone to develop other diseases and require more medical resources than do the general population. However, there are no studies on health-related quality of life (HRQoL) and medical resource use by osteoporosis patients with comorbid depression. We conducted this study for clarifying it. Methods: This cross-sectional study from 2005 to 2010 (6 years) analyzed 9776 National Health and Nutrition Examination Survey (NHANES) patients &gt; 40 years old. Each patient was assigned to one of four groups: osteoporosis-positive(+) and depression-positive(+) (O+\/D+); O+\/D\u2212; O\u2212\/D+; O\u2212\/D\u2212. We used multivariate linear and logistic regression model to analyze the HRQoL and medical resource use between groups. Results: The O+\/D+ group reported more unhealthy days of physical health, more unhealthy days of mental health, and more inactive days during a specified 30 days. The adjusted odds ratios (AORs) of O+\/D+ patients who had poor general health (7.40, 95% CI = 4.80\u201311.40), who needed healthcare (3.25, 95% CI = 2.12\u20135.00), and who had been hospitalized overnight (2.71, 95% CI = 1.89\u20133.90) were significantly highest. Conclusions: Low HRQoL was significantly more prevalent in D+\/O+ patients. We found that depression severity more significantly affected HRQoL than did osteoporosis. However, both diseases significantly increased the risk of high medical resource use.<\/jats:p>","DOI":"10.3390\/ijerph17031124","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T09:25:21Z","timestamp":1581413121000},"page":"1124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Health-Related Quality of Life and Medical Resource Use in Patients with Osteoporosis and Depression: A Cross-Sectional Analysis from the National Health and Nutrition Examination Survey"],"prefix":"10.3390","volume":"17","author":[{"given":"Shih-Feng","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Healthcare Administration and Medical Informatics, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan"},{"name":"Center for Medical informatics and Statistics, Office of R&amp;D, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ru","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Financial Management, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Lin","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Providence University, Taichung 43301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Jen","family":"Tien","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Chi Mei Medical Center, Tainan 71004, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Yun","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Healthcare Administration and Medical Informatics, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: Now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11657-013-0137-0","article-title":"The EU review panel of the IOF. 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