{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:41:25Z","timestamp":1789836085295,"version":"4.0.1"},"reference-count":100,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2018ZX10101-001"],"award-info":[{"award-number":["2018ZX10101-001"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Academy Medical Sciences Initiative for Innovative Medicine","award":["2016-I2M-3-021"],"award-info":[{"award-number":["2016-I2M-3-021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Antimicrobial resistance (AMR) has become a global threat to not only public health impacts but also clinical and economic outcomes. During the past decades, there have been many studies focusing on surveillance, mechanisms, and diagnostics of AMR in infectious diseases but the impacts on public health, clinical and economic outcomes due to emergence of these AMRs are rarely studied and reported. This review was aimed to summarize the findings from published studies to report the outcome impacts due to AMR of malaria, tuberculosis and HIV and briefly discuss the implications for application to other infectious diseases. PubMed\/Medline and Google Scholar databases were used for search of empirical and peer-reviewed papers reporting public health, clinical and economic outcomes due to AMR of malaria, tuberculosis and HIV. Papers published through 1 December 2019 were included in this review. A total of 76 studies were included for this review, including 16, 49 and 11 on public health, clinical and economic outcomes, respectively. The synthesized data indicated that the emergence and spread of AMR of malaria, tuberculosis and HIV have resulted in adverse public health, clinical and economic outcomes. AMR of malaria, tuberculosis and HIV results in significant adverse impacts on public health, clinical and economic outcomes. Evidence from this review suggests the needs to consider the similar studies for other infectious diseases.<\/jats:p>","DOI":"10.3390\/ijerph17041395","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T08:59:47Z","timestamp":1582275587000},"page":"1395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Outcome Impacts Due to Pathogen-Specific Antimicrobial Resistance: A Narrative Review of Published Literature"],"prefix":"10.3390","volume":"17","author":[{"given":"Tingting","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China"},{"name":"National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing 210042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3927-2065","authenticated-orcid":false,"given":"Xiang-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China"},{"name":"National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing 210042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"ref_1","unstructured":"WHO (2019, May 06). Antimicrobial Resistance Fact Sheet. Available online: http:\/\/www.who.int\/mediacentre\/factsheets\/fs194\/en\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.7196\/SAMJ.9644","article-title":"The World Health Organization Global Action Plan for antimicrobial resistance","volume":"105","author":"Mendelson","year":"2015","journal-title":"S. Afr. Med. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: The WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_4","unstructured":"WHO (2018). Global Tuberculosis Report 2018, World Health Organization."},{"key":"ref_5","unstructured":"WHO (2017). Prioritization of Pathogens to Guide Discovery, Research and Development of New Antibiotics for Drug-Resistant Bacterial Infections, Including Tuberculosis, World Health Organization."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0035-9203(77)90213-9","article-title":"Chloroquine-resistant Plasmodium falciparum and malaria in Africa","volume":"71","author":"Olatunde","year":"1977","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0035-9203(90)90246-B","article-title":"The epidemiology of drug-resistant malaria","volume":"84","author":"Bjorkman","year":"1990","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1473-3099(15)00487-9","article-title":"Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: A multisite prospective cohort study","volume":"16","author":"Amaratunga","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_9","first-page":"126","article-title":"Increase in resistance of tubercle bacilli to streptomycin; a preliminary report","volume":"21","author":"Youmans","year":"1946","journal-title":"Proc. Staff Meet. Mayo Clin."},{"key":"ref_10","first-page":"1641","article-title":"Global surveillance for antituberculosis-drug resistance, 1994-1997. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance","volume":"338","author":"Raviglione","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_11","unstructured":"Centers for Disease Control and Prevention (CDC) (2006). Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs\u2014Worldwide, 2000\u20132004. MMWR Morb. Mortal. Wkly. Rep., 55, 301\u2013305."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.2467383","article-title":"HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy","volume":"243","author":"Larder","year":"1989","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1524-475X.2004.04006.x","article-title":"A Process for systematically reviewing the literature: Providing the research evidence for public health nursing interventions","volume":"1","author":"Thomas","year":"2004","journal-title":"Worldviews Evid. Based Nurs."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0035-9203(95)90469-7","article-title":"An epidemic of Plasmodium falciparum malaria in Balcad, Somalia, and its causation","volume":"89","author":"Warsame","year":"1995","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0001-706X(96)00031-9","article-title":"High prevalence of chloroquine resistant Plasmodium falciparum infection in Rajasthan epidemic","volume":"62","author":"Sharma","year":"1996","journal-title":"Acta Trop."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1365-3156.2009.02333.x","article-title":"Impact of delayed introduction of sulfadoxine-pyrimethamine and arthemeter-lumefantrine on malaria epidemiology in KwaZulu-Natal, South Africa","volume":"14","author":"Knight","year":"2009","journal-title":"Trop. Med. Int. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12936-015-1075-7","article-title":"Assessing the potential impact of artemisinin and partner drug resistance in sub-Saharan Africa","volume":"15","author":"Slater","year":"2016","journal-title":"Malar. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/oxfordjournals.aje.a113110","article-title":"Transmission of multiple drug-resistant tuberculosis: Report of a school and community outbreak","volume":"113","author":"Reves","year":"1981","journal-title":"Am. J. Epidemiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1086\/647078","article-title":"Transmission of multidrug-resistant Mycobacterium tuberculosis among persons exposed in a medical examiner\u2019s office, New York","volume":"16","author":"Ussery","year":"1995","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/infdis\/168.4.1052","article-title":"Transmission of multidrug-resistant Mycobacterium tuberculosis among persons with human immunodeficiency virus infection in an urban hospital: Epidemiologic and restriction fragment length polymorphism analysis","volume":"168","author":"Coronado","year":"1993","journal-title":"J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1164\/ajrccm.152.1.7599845","article-title":"Transmission of multidrug-resistant tuberculosis in a large urban setting","volume":"152","author":"Friedman","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_22","unstructured":"Centers for Disease Control (CDC) (1991). Nosocomial transmission of multidrug-resistant tuberculosis among HIV-infected persons\u2014Florida and New York, 1988\u20131991. MMWR Morb. Mortal. Wkly. Rep., 40, 585\u2013591."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1086\/516296","article-title":"A continuing outbreak of multidrug-resistant tuberculosis, with transmission in a hospital nursery","volume":"26","author":"Nivin","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/0033354917694008","article-title":"Outbreak of Drug-Resistant Mycobacterium tuberculosis Among Homeless People in Atlanta, Georgia, 2008\u20132015","volume":"132","author":"Powell","year":"2017","journal-title":"Public Health Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.5588\/ijtld.12.0959","article-title":"Assessment of tuberculosis burden in China using a dynamic disease simulation model","volume":"17","author":"Mehra","year":"2013","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1473-3099(17)30247-5","article-title":"Estimating the future burden of multidrug-resistant and extensively drug-resistant tuberculosis in India, the Philippines, Russia, and South Africa: A mathematical modelling study","volume":"17","author":"Sharma","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nm0901-1016","article-title":"Predicting the unpredictable: Transmission of drug-resistant HIV","volume":"7","author":"Blower","year":"2001","journal-title":"Nat. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1126\/science.1180556","article-title":"Evolutionary dynamics of complex networks of HIV drug-resistant strains: The case of San Francisco","volume":"327","author":"Smith","year":"2010","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/infdis\/jix089","article-title":"Impact of HIV Drug Resistance on HIV\/AIDS-Associated Mortality, New Infections, and Antiretroviral Therapy Program Costs in Sub-Saharan Africa","volume":"215","author":"Phillips","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1086\/649784","article-title":"Quantifying the evolution and impact of antimalarial drug resistance: Drug use, spread of resistance, and drug failure over a 12-year period in Papua New Guinea","volume":"201","author":"Nsanzabana","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4269\/ajtmh.1986.35.465","article-title":"In vivo efficacy of chloroquine treatment for Plasmodium falciparum in Malawian children under five years of age","volume":"35","author":"Khoromana","year":"1986","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_32","first-page":"189","article-title":"Hospital-based surveillance of malaria-related paediatric morbidity and mortality in Kinshasa, Zaire","volume":"67","author":"Greenberg","year":"1989","journal-title":"Bull. World Health Organ."},{"key":"ref_33","first-page":"173","article-title":"Child morbidity and mortality due to cerebral malaria in Brazzaville, Congo. A retrospective and prospective hospital-based study 1983\u20131989","volume":"43","author":"Carme","year":"1992","journal-title":"Trop. Med. Parasitol."},{"key":"ref_34","first-page":"110","article-title":"Upsurge of malaria-related convulsions in a paediatric emergency room in Nigeria. Consequence of emergence of chloroquine-resistant Plasmodium falciparum","volume":"45","author":"Asindi","year":"1993","journal-title":"Trop. Geogr. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4269\/ajtmh.1996.55.655","article-title":"Childhood mortality during and after hospitalization in western Kenya: Effect of malaria treatment regimens","volume":"55","author":"Zucker","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0035-9203(00)90310-9","article-title":"Changing patterns of clinical malaria since 1965 among a tea estate population located in the Kenyan highlands","volume":"94","author":"Shanks","year":"2000","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"386","DOI":"10.4269\/ajtmh.2003.68.386","article-title":"The mortality consequences of the continued use of chloroquine in Africa: Experience in Siaya, western Kenya","volume":"68","author":"Zucker","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/02724936.1993.11747637","article-title":"Seasonal variation of paediatric diseases in The Gambia, west Africa","volume":"13","author":"Brewster","year":"1993","journal-title":"Ann. Trop. Paediatr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12936-015-0794-0","article-title":"Treatment policy change to dihydroartemisinin-piperaquine contributes to the reduction of adverse maternal and pregnancy outcomes","volume":"14","author":"Poespoprodjo","year":"2015","journal-title":"Malar. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1128\/AAC.00835-15","article-title":"Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment","volume":"59","author":"Leang","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1128\/AAC.00686-12","article-title":"Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010","volume":"57","author":"Leang","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1128\/AAC.01712-10","article-title":"Development, evaluation, and application of an in silico model for antimalarial drug treatment and failure","volume":"55","author":"Winter","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1001\/jama.283.19.2537","article-title":"Standard short-course chemotherapy for drug-resistant tuberculosis: Treatment outcomes in 6 countries","volume":"283","author":"Espinal","year":"2000","journal-title":"JAMA"},{"key":"ref_44","first-page":"585","article-title":"Influence of anti-tuberculosis drug resistance on the treatment outcome of pulmonary tuberculosis patients receiving DOTS in Riyadh, Saudi Arabia","volume":"6","author":"Singla","year":"2002","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1046\/j.1469-0691.2003.00547.x","article-title":"Treatment outcome of tuberculosis among Saudi nationals: Role of drug resistance and compliance","volume":"9","author":"Samman","year":"2003","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5539\/gjhs.v5n6p60","article-title":"Effect of mycobacterial drug resistance patterns on patients\u2019 survival: A cohort study in Thailand","volume":"5","author":"Anuwatnonthakate","year":"2013","journal-title":"Glob. J. Health Sci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Deepa, D., Achanta, S., Jaju, J., Rao, K., Samyukta, R., Claassens, M., Kumar, A.M., and Ph, V. (2013). The impact of isoniazid resistance on the treatment outcomes of smear positive re-treatment tuberculosis patients in the state of Andhra Pradesh, India. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076189"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Baez-Saldana, R., Delgado-Sanchez, G., Garcia-Garcia, L., Cruz-Hervert, L.P., Montesinos-Castillo, M., Ferreyra-Reyes, L., Bobadilla-Del-Valle, M., Canizales-Quintero, S., Ferreira-Guerrero, E., and T\u00e9llez-V\u00e1zquez, N. (2016). Isoniazid Mono-Resistant Tuberculosis: Impact on Treatment Outcome and Survival of Pulmonary Tuberculosis Patients in Southern Mexico 1995\u20132010. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0168955"},{"key":"ref_49","first-page":"876","article-title":"Effects of isoniazid resistance on TB treatment outcomes under programmatic conditions in a high-TB and -HIV setting: A prospective multicentre study","volume":"72","author":"Nagu","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1800392","DOI":"10.2807\/1560-7917.ES.2019.24.12.1800392","article-title":"Isoniazid (INH) mono-resistance and tuberculosis (TB) treatment success: Analysis of European surveillance data, 2002 to 2014","volume":"24","author":"Karo","year":"2019","journal-title":"Eur. Surveill."},{"key":"ref_51","first-page":"630","article-title":"Clinical consequences and transmissibility of drug-resistant tuberculosis in southern Mexico","volume":"160","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"ref_52","first-page":"S168","article-title":"Mycobacterium tuberculosis drug resistance in a suburban community in southern Mexico","volume":"4","year":"2000","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_53","first-page":"315","article-title":"Drug resistance of Mycobacterium tuberculosis in Orizaba, Veracruz. Implications for the tuberculosis prevention and control program","volume":"53","author":"Canales","year":"2001","journal-title":"Rev. Investig. Clin."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0035-9203(02)90383-4","article-title":"Impact of resistance to anti-tuberculosis drugs on treatment outcome using World Health Organization standard regimens","volume":"96","author":"Noeske","year":"2002","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s10096-003-1080-6","article-title":"Impact of drug-resistant Mycobacterium tuberculosis on treatment outcome of culture-positive cases of tuberculosis in the Archangel oblast, Russia, in 1999","volume":"23","author":"Toungoussova","year":"2004","journal-title":"Eur. J. Clin. Microbiol. Infect Dis."},{"key":"ref_56","first-page":"283","article-title":"Tuberculosis drug resistance and treatment outcomes under DOTS settings in large cities in the Philippines","volume":"10","author":"Ohkado","year":"2006","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Cox, H., Kebede, Y., Allamuratova, S., Ismailov, G., Davletmuratova, Z., Byrnes, G., Stone, C., Niemann, S., R\u00fcsch-Gerdes, S., and Blok, L. (2006). Tuberculosis recurrence and mortality after successful treatment: Impact of drug resistance. PLoS Med., 3.","DOI":"10.1371\/journal.pmed.0030384"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1590\/S1413-86702007000300007","article-title":"Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia","volume":"11","author":"Matos","year":"2007","journal-title":"Br. J. Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/INF.0b013e318253acf8","article-title":"Impact of drug resistance on clinical outcome in children with tuberculous meningitis","volume":"31","author":"Seddon","year":"2012","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Sun, Y., Harley, D., Vally, H., and Sleigh, A. (2015). Comparison of characteristics and mortality in multidrug resistant (MDR) and non-MDR tuberculosis patients in China. BMC Public Health, 15.","DOI":"10.1186\/s12889-015-2327-8"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Sun, Y., Harley, D., Vally, H., and Sleigh, A. (2017). Impact of Multidrug Resistance on Tuberculosis Recurrence and Long-Term Outcome in China. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0168865"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1086\/318489","article-title":"Clinical outcomes of Estonian patients with primary multidrug-resistant versus drug-susceptible tuberculosis","volume":"32","author":"Lockman","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_63","first-page":"45","article-title":"Treatment outcomes by drug resistance and HIV status among tuberculosis patients in Ho Chi Minh City, Vietnam","volume":"10","author":"Quy","year":"2006","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13756-019-0561-z","article-title":"Treatment outcomes of drug-resistant tuberculosis in the Netherlands, 2005\u20132015","volume":"12","author":"Pradipta","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_65","first-page":"1388","article-title":"Drug susceptibility of Mycobacterium tuberculosis in HIV-infected and -uninfected Ethiopians and its impact on outcome after 24 months of follow-up","volume":"8","author":"Eyob","year":"2004","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_66","first-page":"325","article-title":"Impact of drug-resistant tuberculosis on the survival of HIV-infected patients","volume":"11","author":"Sungkanuparph","year":"2007","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1164\/rccm.200802-240OC","article-title":"Influence of multidrug resistance on tuberculosis treatment outcomes with standardized regimens","volume":"178","author":"Mak","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1183\/09031936.00134712","article-title":"Resistance to fluoroquinolones and second-line injectable drugs: Impact on multidrug-resistant TB outcomes","volume":"42","author":"Falzon","year":"2013","journal-title":"Eur. Respir. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1097\/00002030-199910010-00008","article-title":"Baseline HIV drug resistance profile predicts response to ritonavir-saquinavir protease inhibitor therapy in a community setting","volume":"13","author":"Harrigan","year":"1999","journal-title":"Aids"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1086\/528802","article-title":"Preexisting resistance to nonnucleoside reverse-transcriptase inhibitors predicts virologic failure of an efavirenz-based regimen in treatment-naive HIV-1-infected subjects","volume":"197","author":"Kuritzkes","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1089\/aid.2011.0022","article-title":"Transmitted drug-resistant HIV type 1 remains prevalent and impacts virologic outcomes despite genotype-guided antiretroviral therapy","volume":"28","author":"Taniguchi","year":"2012","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1086\/596736","article-title":"Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes","volume":"199","author":"Simen","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1086\/515304","article-title":"Dual resistance to zidovudine and lamivudine in patients treated with zidovudine-lamivudine combination therapy: Association with therapy failure","volume":"177","author":"Miller","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1097\/00126334-200412150-00022","article-title":"Current levels of drug resistance among therapy-naive HIV-infected patients have significant impact on treatment response","volume":"37","author":"Derdelinckx","year":"2004","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/jac\/dkr601","article-title":"Trends of transmitted drug resistance of HIV-1 and its impact on treatment response to first-line antiretroviral therapy in Taiwan","volume":"67","author":"Lai","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1097\/01.aids.0000174455.01369.ad","article-title":"Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients","volume":"19","author":"Zaccarelli","year":"2005","journal-title":"Aids"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1097\/QAD.0b013e328310e04f","article-title":"Detection of HIV drug resistance during antiretroviral treatment and clinical progression in a large European cohort study","volume":"22","author":"Phillips","year":"2008","journal-title":"Aids"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2165\/00019053-199610030-00004","article-title":"Economic implications of resistance to antimalarial drugs","volume":"10","author":"Phillips","year":"1996","journal-title":"Pharmacoeconomics"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/1475-2875-13-452","article-title":"Artemisinin resistance\u2014Modelling the potential human and economic costs","volume":"13","author":"Lubell","year":"2014","journal-title":"Malar. J."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Pooran, A., Pieterson, E., Davids, M., Theron, G., and Dheda, K. (2013). What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa?. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054587"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"828","DOI":"10.5588\/ijtld.11.0688","article-title":"Non-hospital DOT and early diagnosis of tuberculosis reduce costs while achieving treatment success","volume":"16","author":"Pichenda","year":"2012","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1136\/thorax.55.11.962","article-title":"Resource implications of patients with multidrug resistant tuberculosis","volume":"55","author":"White","year":"2000","journal-title":"Thora"},{"key":"ref_83","first-page":"1316","article-title":"Patient and family costs associated with tuberculosis, including multidrug-resistant tuberculosis, in Ecuador","volume":"14","author":"Rouzier","year":"2010","journal-title":"Int. J. Tuberc. Lung"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"435","DOI":"10.5588\/ijtld.15.0575","article-title":"Characteristics and costs of multidrug-resistant tuberculosis in-patient care in the United States, 2005\u20132007","volume":"20","author":"Marks","year":"2016","journal-title":"Int. J. Tuberc. Lung"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3201\/eid2005.131037","article-title":"Treatment practices, outcomes, and costs of multidrug-resistant and extensively drug-resistant tuberculosis, United States, 2005\u20132007","volume":"20","author":"Marks","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3851\/IMP2709","article-title":"The cost of antiretroviral drug resistance in HIV-positive patients","volume":"19","author":"Krentz","year":"2014","journal-title":"Antivir. Ther."},{"key":"ref_87","unstructured":"Martin, S. (2007, January 22\u201325). Incremental medical costs associated with increased changes in HAART regimens in a US patient sample. Proceedings of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Sydney, Australia."},{"key":"ref_88","first-page":"52","article-title":"Incidence-based Costs of Multiple HAART Switches Among HIV infected Patients in an HMO","volume":"8","author":"Meenan","year":"2010","journal-title":"Clin. Med. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4269\/ajtmh.2001.64.28","article-title":"The burden of malaria in pregnancy in malaria-endemic areas","volume":"64","author":"Steketee","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4269\/ajtmh.2001.64.57","article-title":"Gaps in the childhood malaria burden in Africa: Cerebral malaria, neurological sequelae, anemia, respiratory distress, hypoglycemia, and complications of pregnancy","volume":"64","author":"Murphy","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(07)60160-3","article-title":"Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: An open-label randomised comparison","volume":"369","author":"Ratcliff","year":"2007","journal-title":"Lancet"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Snedecor, S.J., Khachatryan, A., Nedrow, K., Chambers, R., Li, C., Haider, S., and Stephens, J. (2013). The prevalence of transmitted resistance to first-generation non-nucleoside reverse transcriptase inhibitors and its potential economic impact in HIV-infected patients. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072784"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/infdis\/jiv517","article-title":"Improving Control of Antibiotic-Resistant Gonorrhea by Integrating Research Agendas Across Disciplines: Key Questions Arising from Mathematical Modeling","volume":"213","author":"Grad","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1586\/14787210.6.5.751","article-title":"Clinical and economic burden of antimicrobial resistance","volume":"6","author":"Maragakis","year":"2008","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/1469-0691.12798","article-title":"Economic burden of antibiotic resistance: How much do we really know?","volume":"20","author":"Gandra","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Unemo, M., Del Rio, C., and Shafer, W.M. (Microbiol. Spectr., 2016). Antimicrobial Resistance Expressed by Neisseria gonorrhoeae: A Major Global Public Health Problem in the 21st Century, Microbiol. Spectr.","DOI":"10.1128\/microbiolspec.EI10-0009-2015"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3201\/eid2004.131288","article-title":"Ciprofloxacin resistance and gonorrhea incidence rates in 17 cities, United States, 1991\u20132006","volume":"20","author":"Chesson","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/OLQ.0000000000000725","article-title":"An Illustration of the Potential Health and Economic Benefits of Combating Antibiotic-Resistant Gonorrhea","volume":"45","author":"Chesson","year":"2018","journal-title":"Sex Transm. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1473-3099(12)70261-X","article-title":"UK investments in global infectious disease research 1997\u20132010: A case study","volume":"13","author":"Head","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/cid\/ciy566","article-title":"A Roadmap Plan to Address Research Needs for Gonococcal Antimicrobial Resistance in China","volume":"68","author":"Chen","year":"2019","journal-title":"Clin. Infect. Dis."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/4\/1395\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:59:46Z","timestamp":1760173186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/4\/1395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":100,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["ijerph17041395"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17041395","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,21]]}}}