{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:46:36Z","timestamp":1760237196564,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T00:00:00Z","timestamp":1584144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Implants inserted in the posterior maxilla frequently need additional surgery for successful bone augmentation. One of the most common procedures for this is transalveolar sinus floor elevation. There are different protocols for this procedure, and there is controversy over the simultaneous application of grafting material upon elevating. In this prospective randomized clinical study in humans, a total of 49 transalveolar sinus floor elevations were performed in 49 different patients, divided into a control group (without graft, 25 patients) and a test group (with graft, 24 patients). The analyzed variables were obtained through digital orthopantomography on day 0 (day of surgery) and 18 months after surgery. These measurements showed a tendency towards greater vertical bone gain in the test group, but this was not statistically significant. Therefore, considering that sinus elevation and implant placement without the application of grafts is a successful treatment with fewer complications, a critical assessment of the need for these biomaterials is necessary.<\/jats:p>","DOI":"10.3390\/ijerph17061888","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T08:20:44Z","timestamp":1584519644000},"page":"1888","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of the Simultaneous Use of Biomaterials in Transalveolar Sinus Floor Elevation: Prospective Randomized Clinical Trial in Humans"],"prefix":"10.3390","volume":"17","author":[{"given":"Adri\u00e1n","family":"Maximiano Mill\u00e1n","sequence":"first","affiliation":[{"name":"Periodontics, Faculty of Health and Sport Sciences, Universidad de Zaragoza, C\/Vel\u00f3dromo S\/N, 22006 Huesca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Bravo \u00c1lvarez","sequence":"additional","affiliation":[{"name":"Periodontics, Faculty of Health and Sport Sciences, Universidad de Zaragoza, C\/Vel\u00f3dromo S\/N, 22006 Huesca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Plana Montori","sequence":"additional","affiliation":[{"name":"Periodontics, Faculty of Health and Sport Sciences, Universidad de Zaragoza, C\/Vel\u00f3dromo S\/N, 22006 Huesca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Guerrero Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Periodontics, Faculty of Health and Sport Sciences, Universidad de Zaragoza, C\/Vel\u00f3dromo S\/N, 22006 Huesca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Saura Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Periodontics, Faculty of Health and Sport Sciences, Universidad de Zaragoza, C\/Vel\u00f3dromo S\/N, 22006 Huesca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-5902","authenticated-orcid":false,"given":"Blanca","family":"R\u00edos-Carrasco","sequence":"additional","affiliation":[{"name":"Advanced Periodontics, School of Dentistry, Universidad de Sevilla, C\/Avicena S\/N, 41009 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Monticelli","sequence":"additional","affiliation":[{"name":"Periodontics, Faculty of Health and Sport Sciences, Universidad de Zaragoza, C\/Vel\u00f3dromo S\/N, 22006 Huesca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-6166","authenticated-orcid":false,"given":"Jos\u00e9 Vicente","family":"R\u00edos-Santos","sequence":"additional","affiliation":[{"name":"Advanced Periodontics, School of Dentistry, Universidad de Sevilla, C\/Avicena S\/N, 41009 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Fern\u00e1ndez-Palac\u00edn","sequence":"additional","affiliation":[{"name":"Department. of Sociosanitary Sciences Facultad de Medicina, Universidad de Sevilla, Avda. Dr. Fedriani, S\/N, 41009 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1600-051X.1981.tb02039.x","article-title":"The significance of maintenance care in the treatment of periodontal disease","volume":"8","author":"Axelsson","year":"1981","journal-title":"J. Clin. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1902\/jop.1984.55.9.499","article-title":"Molar and nonmolar teeth compared over 6\u00bd years following two methods of periodontal therapy","volume":"55","author":"Pihlstrom","year":"1984","journal-title":"J. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1902\/jop.1988.59.12.794","article-title":"Evaluation of furcation region response to periodontal therapy","volume":"59","author":"Kalkwarf","year":"1988","journal-title":"J. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1902\/jop.1978.49.5.225","article-title":"A long-term survey of tooth loss in 600 treated periodontal patients","volume":"49","author":"Hirschfeld","year":"1978","journal-title":"J. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/ar.a.10119","article-title":"Bone\u2019s mechanostat: A 2003 update","volume":"275","author":"Frost","year":"2003","journal-title":"Anat. Rec."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ar.1092190104","article-title":"Bone \u201cmass\u201d and the \u201cmechanostat\u201d: A proposal","volume":"219","author":"Frost","year":"1987","journal-title":"Anat. Rec."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1034\/j.1600-0501.1999.100601.x","article-title":"Lack of integration of smooth titanium surfaces: A working hypothesis based on strains generated in the surrounding bone","volume":"10","author":"Wiskott","year":"1999","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_8","first-page":"49","article-title":"Maxillary sinus augmentation for endosteal implants: Organized alternative treatment plans","volume":"4","author":"Misch","year":"1987","journal-title":"Int. J. Oral Implant.."},{"key":"ref_9","first-page":"11","article-title":"Report of the sinus consensus conference of 1996","volume":"13","author":"Jensen","year":"1998","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1034\/j.1600-051X.2003.00366.x","article-title":"Dynamics of bone tissue formation in tooth extraction sites. An experimental study in dogs","volume":"30","author":"Cardaropoli","year":"2003","journal-title":"J. Clin. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1600-051X.2005.00693.x","article-title":"Bone regeneration at implants with turned or rough surfaces in self-contained defects. An experimental study in the dog","volume":"32","author":"Botticelli","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"ref_12","first-page":"39","article-title":"Tissue integrated dental prostheses","volume":"16","author":"Zarb","year":"1985","journal-title":"Quintessence Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0011-8532(22)02107-3","article-title":"Maxillary and sinus implant reconstructions","volume":"30","author":"Tatum","year":"1986","journal-title":"Dent. Clin. North Am."},{"key":"ref_14","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne","year":"1980","journal-title":"J. Oral Surg."},{"key":"ref_15","first-page":"853","article-title":"The bone-added osteotome sinus floor elevation technique: Multicenter retrospective report of consecutively treated patients","volume":"14","author":"Rosen","year":"1999","journal-title":"Int. J. Oral Maxillofac. Implant"},{"key":"ref_16","first-page":"154","article-title":"A new concept in maxillary implant surgery: The osteotome technique","volume":"15","author":"Summers","year":"1994","journal-title":"Compendium"},{"key":"ref_17","first-page":"422","article-title":"The osteotome technique: Part 2\u2014The ridge expansion osteotomy (REO) procedure","volume":"15","author":"Summers","year":"1994","journal-title":"Compendium"},{"key":"ref_18","first-page":"694","article-title":"The osteotome technique: Part 3\u2014Less invasive methods of elevating the sinus floor","volume":"15","author":"Summers","year":"1994","journal-title":"Compendium"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1902\/jop.2005.76.8.1237","article-title":"Sinus floor elevation using osteotomes: A systematic review and meta-analysis","volume":"76","author":"Emmerich","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_20","first-page":"110","article-title":"A meta-analysis of clinical studies to estimate the 4.5-year survival rate of implants placed with the osteotome technique","volume":"22","author":"Shalabi","year":"2007","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_21","first-page":"175","article-title":"A review of survival rates for implants placed in grafted maxillary sinuses using meta-analysis","volume":"13","author":"Tong","year":"1998","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/clr.12893","article-title":"Short implants placed with or without grafting into atrophic sinuses: The 5-year results of a prospective randomized controlled study","volume":"28","author":"Nedir","year":"2017","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1600-0501.2012.02569.x","article-title":"Osteotome sinus floor elevation with and without grafting material in the severely atrophic maxilla. A 1-year prospective randomized controlled study","volume":"24","author":"Nedir","year":"2013","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/cid.12279","article-title":"Short implants placed with or without grafting in atrophic sinuses: The 3-year results of a prospective randomized controlled study","volume":"18","author":"Nedir","year":"2016","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2174\/1874210601711010621","article-title":"Correlation between metabolic syndrome, periodontitis and reactive oxygen species production. A pilot study","volume":"11","author":"Patini","year":"2017","journal-title":"Open Dent. J."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Martellaci, L., Quaranta, G., Patini, R., Isola, G., Gallenzi, P., and Masucci, L. (2019). A literature review of metagenomics and culturomics of the peri-implant microbiome: Current evidence and future perspectives. Materials, 12.","DOI":"10.3390\/ma12183010"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/cid.12373","article-title":"Two-center prospective, randomized, clinical, and radiographic study comparing osteotome sinus floor elevation with or without bone graft and simultaneous implant placement","volume":"18","author":"Markovic","year":"2016","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.12659\/MSM.910739","article-title":"Radiological changes associated with new bone formation following osteotome sinus floor elevation (OSFE): A retrospective study of 40 patients with 18-month follow-up","volume":"24","author":"Yang","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/jopr.12576","article-title":"Clinical and radiological outcomes of implants in osteotome sinus floor elevation with and without grafting: A systematic review and a meta-analysis","volume":"27","author":"Chen","year":"2018","journal-title":"J. Prosthodont."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/ID.0000000000000798","article-title":"Osteotome-mediated sinus floor elevation with or without a grafting material: A systematic review and meta-analysis of long-term studies (>\/=5-Years)","volume":"27","author":"Aludden","year":"2018","journal-title":"Implant Dent."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/cid.12530","article-title":"Long-term evaluation of osteotome sinus floor elevation and simultaneous placement of implants without bone grafts: 10-year radiographic and clinical follow-up","volume":"19","author":"Caban","year":"2017","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/cid.12331","article-title":"Osteotome sinus floor elevation without grafting: A 10-year prospective study","volume":"18","author":"Nedir","year":"2016","journal-title":"Clin. Implant Dent. Relat. Res."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/6\/1888\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:06:51Z","timestamp":1760173611000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/17\/6\/1888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,14]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["ijerph17061888"],"URL":"https:\/\/doi.org\/10.3390\/ijerph17061888","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2020,3,14]]}}}